AutismKB 2.0

Annotation Detail for UNC119


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Basic Information Top
Gene Symbol:UNC119 ( HRG4,POC7,POC7A )
Gene Full Name: unc-119 homolog (C. elegans)
Band: 17q11.2
Quick LinksEntrez ID:9094; OMIM: 604011; Uniprot ID:U119A_HUMAN; ENSEMBL ID: ENSG00000109103; HGNC ID: 12565
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus26 / 56401246
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult133 / 193912168
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor3 / 3436687
chondrosarcoma2 / 8282324
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor4 / 26384515
glioma4 / 10688337
head and neck tumor4 / 13630229
kidney tumor4 / 6895958
leukemia8 / 9584283
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma3 / 7175541
non-neoplasia0 / 972500 
normal186 / 336030755
ovarian tumor7 / 7668291
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor6 / 12494948
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites1 / 4001524
bladder0 / 297570 
blood13 / 123478105
bone1 / 7165513
bone marrow0 / 488010 
brain16 / 110098914
cervix3 / 4817162
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus1 / 2020949
eye59 / 211054279
heart1 / 8962611
intestine4 / 23447217
kidney7 / 21177733
larynx1 / 2414541
liver4 / 20774319
lung13 / 33697438
lymph3 / 4427067
lymph node11 / 91610120
mammary gland5 / 15327132
mouth1 / 6705214
muscle4 / 10771537
nerve0 / 157680 
ovary7 / 10205168
pancreas8 / 21481237
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta6 / 28082521
prostate9 / 18934547
salivary gland3 / 20155148
skin6 / 21057428
spleen0 / 539520 
stomach5 / 9661951
testis16 / 33044248
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus16 / 23287868
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203271_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts127.75
Adipocyte20.25
AdrenalCortex23.25
Adrenalgland19.55
Amygdala24.8
Appendix21.75
AtrioventricularNode14.95
BDCA4+_DentriticCells101.85
Bonemarrow22.65
BronchialEpithelialCells20.1
CD105+_Endothelial21.85
CD14+_Monocytes70.85
CD19+_BCells(neg._sel.)46.2
CD33+_Myeloid75.8
CD34+20.75
CD4+_Tcells26.1
CD56+_NKCells97.35
CD71+_EarlyErythroid17.3
CD8+_Tcells20
CardiacMyocytes24.3
Caudatenucleus21.6
Cerebellum32.8
CerebellumPeduncles44.7
CiliaryGanglion13.25
CingulateCortex43.1
Colorectaladenocarcinoma23.2
DorsalRootGanglion14.1
FetalThyroid22.5
Fetalbrain30.05
Fetalliver21.05
Fetallung17.5
GlobusPallidus22.95
Heart28.75
Hypothalamus30.3
Kidney23.75
Leukemia_chronicMyelogenousK-56220.85
Leukemia_promyelocytic-HL-6059.15
Leukemialymphoblastic(MOLT-4)21.65
Liver39.75
Lung22.85
Lymphnode32.85
Lymphoma_burkitts(Daudi)29.3
Lymphoma_burkitts(Raji)490.25
MedullaOblongata21.5
OccipitalLobe28.7
OlfactoryBulb21.95
Ovary15
Pancreas21.45
PancreaticIslet24.65
ParietalLobe25.45
Pituitary25.4
Placenta18.6
Pons28.3
PrefrontalCortex41
Prostate27.2
Salivarygland16.3
SkeletalMuscle31.4
Skin16.55
SmoothMuscle25.2
Spinalcord28.15
SubthalamicNucleus41.2
SuperiorCervicalGanglion23.05
TemporalLobe44.9
Testis54.05
TestisGermCell47.45
TestisIntersitial19.6
TestisLeydigCell23.5
TestisSeminiferousTubule24.55
Thalamus40.4
Thymus18.65
Thyroid29.4
Tongue22
Tonsil22.45
Trachea23.4
TrigeminalGanglion18.15
Uterus11.15
UterusCorpus18.35
WholeBlood123.9
Wholebrain20.35
colon17.85
pineal_day38.1
pineal_night26.8
retina402.025
small_intestine17.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11899_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.72 ± 0.6
Basal Forebrain3.15 ± 0.5
Basal Part of Pons3.78 ± 0.57
Cerebellar Cortex3.75 ± 0.52
Cerebellar Nuclei3.74 ± 0.46
Claustrum3.06 ± 0.71
Epithalamus3.35 ± 0.6
Frontal Lobe3.76 ± 0.56
Globus Pallidus2.92 ± 0.61
Hypothalamus3.99 ± 0.76
Insula3.81 ± 0.4
Limbic Lobe3.56 ± 0.6
Mesencephalon3.52 ± 0.61
Myelencephalon3.52 ± 0.68
Occipital Lobe3.01 ± 0.64
Parietal Lobe3.61 ± 0.53
Pontine Tegmentum3.51 ± 0.62
Striatum2.72 ± 0.7
Subthalamus3.57 ± 0.3
Temporal Lobe3.68 ± 0.51
Thalamus3.36 ± 0.54
White Matter2.11 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Unc119CBCerebellum0.41
0.46
Unc119CTXCerebral cortex0.72
0.72
Unc119HIPHippocampal region3.99
3.17
Unc119HPFHippocampal formation3.98
3.04
Unc119HYHypothalamus2.1
2.92
Unc119LSXLateral septal complex0.02
0
Unc119MBMidbrain1.09
1.76
Unc119MYMedulla1.45
2.02
Unc119OLFOlfactory bulb2.16
1.87
Unc119PPons2.9
3.8
Unc119PALPallidum0.32
0.36
Unc119RHPRetrohippocampal region3.74
2.65
Unc119sAMYStriatum-like amygdalar nuclei1.5
1.03
Unc119STRStriatum0.48
0.33
Unc119STRdStriatum dorsal region0.06
0.05
Unc119STRvStriatum ventral region1.76
1.1
Unc119THThalamus0.84
0.7
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
U119A_HUMAN_51 6 51 56 PGPLQR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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