AutismKB 2.0

Annotation Detail for USP8


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Basic Information Top
Gene Symbol:USP8 ( FLJ34456,HumORF8,KIAA0055,MGC129718,UBPY )
Gene Full Name: ubiquitin specific peptidase 8
Band: 15q21.2
Quick LinksEntrez ID:9101; OMIM: 603158; Uniprot ID:UBP8_HUMAN; ENSEMBL ID: ENSG00000138592; HGNC ID: 12631
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst2 / 6231932
fetus51 / 56401290
neonate3 / 3109796
infant0 / 236200 
juvenile2 / 5555635
adult98 / 193912150
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma4 / 17475228
breast (mammary gland) tumor2 / 9417821
cervical tumor2 / 3436658
chondrosarcoma3 / 8282336
colorectal tumor4 / 11424635
esophageal tumor2 / 17290115
gastrointestinal tumor7 / 11936958
germ cell tumor7 / 26384526
glioma4 / 10688337
head and neck tumor11 / 13630280
kidney tumor2 / 6895929
leukemia11 / 95842114
liver tumor8 / 9635983
lung tumor4 / 10312738
lymphoma1 / 7175513
non-neoplasia4 / 9725041
normal228 / 336030767
ovarian tumor8 / 76682104
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor5 / 12494940
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor10 / 90257110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites3 / 4001574
bladder4 / 29757134
blood10 / 12347880
bone1 / 7165513
bone marrow6 / 48801122
brain49 / 110098944
cervix2 / 4817141
connective tissue5 / 14925533
ear5 / 16212308
embryonic tissue8 / 21572237
esophagus2 / 2020998
eye8 / 21105437
heart0 / 896260 
intestine8 / 23447234
kidney21 / 21177799
larynx1 / 2414541
liver24 / 207743115
lung23 / 33697468
lymph1 / 4427022
lymph node7 / 9161076
mammary gland7 / 15327145
mouth8 / 67052119
muscle11 / 107715102
nerve0 / 157680 
ovary10 / 10205197
pancreas14 / 21481265
parathyroid2 / 2053997
pharynx3 / 4132872
pituitary gland1 / 1658560
placenta13 / 28082546
prostate6 / 18934531
salivary gland3 / 20155148
skin18 / 21057485
spleen0 / 539520 
stomach3 / 9661931
testis41 / 330442124
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord1 / 1368073
uterus19 / 23287881
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202745_at
Cell line Expression level Expression bar
721_B_lymphoblasts19.45
Adipocyte6.3
AdrenalCortex6.7
Adrenalgland5.3
Amygdala7.6
Appendix6.85
AtrioventricularNode5.35
BDCA4+_DentriticCells33.65
Bonemarrow6.35
BronchialEpithelialCells6.75
CD105+_Endothelial25.3
CD14+_Monocytes38.95
CD19+_BCells(neg._sel.)47
CD33+_Myeloid106.7
CD34+24.35
CD4+_Tcells12.45
CD56+_NKCells72.25
CD71+_EarlyErythroid7.55
CD8+_Tcells10.95
CardiacMyocytes8.2
Caudatenucleus5.6
Cerebellum5
CerebellumPeduncles7.1
CiliaryGanglion4.55
CingulateCortex6.45
Colorectaladenocarcinoma6.3
DorsalRootGanglion4.85
FetalThyroid6.2
Fetalbrain5.55
Fetalliver5.55
Fetallung5.25
GlobusPallidus4.65
Heart8.05
Hypothalamus8.7
Kidney5.15
Leukemia_chronicMyelogenousK-5625.85
Leukemia_promyelocytic-HL-605.6
Leukemialymphoblastic(MOLT-4)5.15
Liver8.45
Lung6.45
Lymphnode5.45
Lymphoma_burkitts(Daudi)8
Lymphoma_burkitts(Raji)8.9
MedullaOblongata5.6
OccipitalLobe6.45
OlfactoryBulb4.65
Ovary4.2
Pancreas4.9
PancreaticIslet6.9
ParietalLobe6.6
Pituitary9.1
Placenta5.85
Pons5.9
PrefrontalCortex12.35
Prostate7.2
Salivarygland5.3
SkeletalMuscle7.35
Skin4.9
SmoothMuscle7.2
Spinalcord6.75
SubthalamicNucleus5.85
SuperiorCervicalGanglion7.3
TemporalLobe5.75
Testis5.3
TestisGermCell11.1
TestisIntersitial9.2
TestisLeydigCell6.25
TestisSeminiferousTubule5.45
Thalamus6.45
Thymus5.1
Thyroid13.25
Tongue6.25
Tonsil6.15
Trachea4.9
TrigeminalGanglion6.45
Uterus12.7
UterusCorpus5.65
WholeBlood15
Wholebrain4.6
colon6.35
pineal_day36.94
pineal_night38.22
retina7.275
small_intestine7.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P129058
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.66 ± 0.36
Basal Forebrain6.12 ± 0.38
Basal Part of Pons6 ± 0.28
Cerebellar Cortex6.07 ± 0.33
Cerebellar Nuclei6.38 ± 0.42
Claustrum5.4 ± 0.71
Epithalamus6.35 ± 0.55
Frontal Lobe5.99 ± 0.43
Globus Pallidus6.31 ± 0.23
Hypothalamus6.13 ± 0.27
Insula5.96 ± 0.28
Limbic Lobe5.71 ± 0.41
Mesencephalon5.99 ± 0.45
Myelencephalon5.88 ± 0.43
Occipital Lobe5.82 ± 0.49
Parietal Lobe5.99 ± 0.37
Pontine Tegmentum5.98 ± 0.45
Striatum5.68 ± 0.36
Subthalamus6.33 ± 0.31
Temporal Lobe5.95 ± 0.31
Thalamus6 ± 0.34
White Matter6.28 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Usp8CBCerebellum22.3
29.58
Usp8CTXCerebral cortex20.25
15.61
Usp8HIPHippocampal region22.09
22.74
Usp8HPFHippocampal formation23.66
21.61
Usp8HYHypothalamus20.39
16.56
Usp8LSXLateral septal complex3.64
3.06
Usp8MBMidbrain23.61
24.69
Usp8MYMedulla34.64
44.43
Usp8OLFOlfactory bulb20.61
16.35
Usp8PPons34.41
40.39
Usp8PALPallidum21.89
22.04
Usp8RHPRetrohippocampal region26.53
20.06
Usp8sAMYStriatum-like amygdalar nuclei11.91
8.74
Usp8STRStriatum6.22
5.36
Usp8STRdStriatum dorsal region4.91
4.77
Usp8STRvStriatum ventral region9.84
7.08
Usp8THThalamus19.95
18.02
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00067120 15 1083 1097 FDDHEVSDISVSSVK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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