AutismKB 2.0

Annotation Detail for SLC16A3


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Basic Information Top
Gene Symbol:SLC16A3 ( MCT3,MCT4,MGC138472,MGC138474 )
Gene Full Name: solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
Band: 17q25.3
Quick LinksEntrez ID:9123; OMIM: 603877; Uniprot ID:MOT4_HUMAN; ENSEMBL ID: ENSG00000141526; HGNC ID: 10924
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body13 / 70761183
blastocyst5 / 6231980
fetus18 / 56401231
neonate5 / 31097160
infant1 / 2362042
juvenile3 / 5555653
adult185 / 193912195
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor3 / 3436687
chondrosarcoma22 / 82823265
colorectal tumor18 / 114246157
esophageal tumor5 / 17290289
gastrointestinal tumor2 / 11936916
germ cell tumor24 / 26384590
glioma10 / 10688393
head and neck tumor3 / 13630222
kidney tumor47 / 68959681
leukemia8 / 9584283
liver tumor4 / 9635941
lung tumor28 / 103127271
lymphoma2 / 7175527
non-neoplasia10 / 97250102
normal245 / 336030772
ovarian tumor9 / 76682117
pancreatic tumor22 / 104616210
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer19 / 102680185
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood17 / 123478137
bone16 / 71655223
bone marrow1 / 4880120
brain28 / 110098925
cervix12 / 48171249
connective tissue17 / 149255113
ear0 / 162120 
embryonic tissue22 / 215722101
esophagus6 / 20209296
eye26 / 211054123
heart4 / 8962644
intestine34 / 234472145
kidney63 / 211777297
larynx0 / 241450 
liver8 / 20774338
lung70 / 336974207
lymph1 / 4427022
lymph node9 / 9161098
mammary gland4 / 15327126
mouth0 / 670520 
muscle6 / 10771555
nerve0 / 157680 
ovary25 / 102051244
pancreas22 / 214812102
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta53 / 280825188
prostate21 / 189345110
salivary gland0 / 201550 
skin20 / 21057494
spleen2 / 5395237
stomach1 / 9661910
testis18 / 33044254
thymus0 / 811310 
thyroid4 / 4747384
tonsil1 / 1699958
trachea2 / 5241338
umbilical cord1 / 1368073
uterus9 / 23287838
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202855_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts103.65
Adipocyte3.5
AdrenalCortex3.75
Adrenalgland3
Amygdala3.75
Appendix3.55
AtrioventricularNode2.7
BDCA4+_DentriticCells45.6
Bonemarrow4.55
BronchialEpithelialCells306.6
CD105+_Endothelial3.65
CD14+_Monocytes98.5
CD19+_BCells(neg._sel.)3.85
CD33+_Myeloid223.5
CD34+4.8
CD4+_Tcells3.9
CD56+_NKCells41.45
CD71+_EarlyErythroid3.35
CD8+_Tcells3.5
CardiacMyocytes189.9
Caudatenucleus3.15
Cerebellum2.9
CerebellumPeduncles4.05
CiliaryGanglion2.5
CingulateCortex3.65
Colorectaladenocarcinoma204.55
DorsalRootGanglion2.75
FetalThyroid3.45
Fetalbrain3.55
Fetalliver3.1
Fetallung2.95
GlobusPallidus2.6
Heart4.55
Hypothalamus3.9
Kidney2.9
Leukemia_chronicMyelogenousK-5623.25
Leukemia_promyelocytic-HL-603.2
Leukemialymphoblastic(MOLT-4)2.9
Liver4.75
Lung18.3
Lymphnode3.05
Lymphoma_burkitts(Daudi)4.55
Lymphoma_burkitts(Raji)5
MedullaOblongata3.25
OccipitalLobe3.2
OlfactoryBulb2.85
Ovary2.4
Pancreas2.9
PancreaticIslet3.8
ParietalLobe3.75
Pituitary4.15
Placenta31.9
Pons3.4
PrefrontalCortex4.4
Prostate4.2
Salivarygland2.85
SkeletalMuscle4.2
Skin2.75
SmoothMuscle339.6
Spinalcord3.8
SubthalamicNucleus3.3
SuperiorCervicalGanglion4.05
TemporalLobe3.25
Testis3.1
TestisGermCell4.55
TestisIntersitial3
TestisLeydigCell3.55
TestisSeminiferousTubule3.05
Thalamus3.6
Thymus2.8
Thyroid6.2
Tongue3.5
Tonsil3.45
Trachea3.05
TrigeminalGanglion3.55
Uterus2.95
UterusCorpus3.2
WholeBlood180.3
Wholebrain3.05
colon3.6
pineal_day4.46
pineal_night4.36
retina75.6
small_intestine3.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_4948_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.56 ± 1.12
Basal Forebrain3.19 ± 0.63
Basal Part of Pons2.62 ± 0.54
Cerebellar Cortex3.09 ± 0.77
Cerebellar Nuclei3.44 ± 0.36
Claustrum3.81 ± 1.1
Epithalamus2.57 ± 1.18
Frontal Lobe2.9 ± 0.85
Globus Pallidus3.45 ± 0.74
Hypothalamus2.93 ± 0.91
Insula2.95 ± 0.64
Limbic Lobe3.07 ± 0.89
Mesencephalon3.28 ± 0.91
Myelencephalon3.1 ± 0.93
Occipital Lobe3.09 ± 0.79
Parietal Lobe3.01 ± 0.95
Pontine Tegmentum2.94 ± 0.83
Striatum3.1 ± 0.94
Subthalamus3.02 ± 0.25
Temporal Lobe2.98 ± 0.86
Thalamus3.04 ± 0.72
White Matter3 ± 0.47
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Slc16a3CBCerebellum0.2
0.39
Slc16a3CTXCerebral cortex0.46
0.64
Slc16a3HIPHippocampal region0.15
0.24
Slc16a3HPFHippocampal formation0.27
0.29
Slc16a3HYHypothalamus0.09
0.11
Slc16a3LSXLateral septal complex0.12
0.15
Slc16a3MBMidbrain0.26
0.62
Slc16a3MYMedulla0.24
0.32
Slc16a3OLFOlfactory bulb0.3
0.69
Slc16a3PPons0.29
0.46
Slc16a3PALPallidum0.13
0.15
Slc16a3RHPRetrohippocampal region0.45
0.36
Slc16a3sAMYStriatum-like amygdalar nuclei0.18
0.27
Slc16a3STRStriatum0.14
0.17
Slc16a3STRdStriatum dorsal region0.1
0.11
Slc16a3STRvStriatum ventral region0.25
0.26
Slc16a3THThalamus0.23
0.25
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MOT4_HUMAN_0 0 0 0 EPQPEVAAAEEEK PRIDE
MOT4_HUMAN_0 0 0 0 LHKPPADSGVDLR PRIDE
MOT4_HUMAN_415 13 415 427 EPQPEVAAAEEEK PRIDE
MOT4_HUMAN_428 13 428 440 LHKPPADSGVDLR PRIDE
PAp00041489 13 429 441 LHKPPADSGVDLR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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