AutismKB 2.0

Annotation Detail for HGS


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Basic Information Top
Gene Symbol:HGS ( HRS,Vps27,ZFYVE8 )
Gene Full Name: hepatocyte growth factor-regulated tyrosine kinase substrate
Band: 17q25.3
Quick LinksEntrez ID:9146; OMIM: 604375; Uniprot ID:HGS_HUMAN; ENSEMBL ID: ENSG00000185359; HGNC ID: 4897
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst7 / 62319112
fetus16 / 56401228
neonate2 / 3109764
infant0 / 236200 
juvenile5 / 5555689
adult156 / 193912180
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma6 / 17475343
breast (mammary gland) tumor11 / 94178116
cervical tumor3 / 3436687
chondrosarcoma11 / 82823132
colorectal tumor18 / 114246157
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor23 / 26384587
glioma21 / 106883196
head and neck tumor21 / 136302154
kidney tumor10 / 68959145
leukemia13 / 95842135
liver tumor6 / 9635962
lung tumor14 / 103127135
lymphoma5 / 7175569
non-neoplasia3 / 9725030
normal169 / 336030750
ovarian tumor2 / 7668226
pancreatic tumor17 / 104616162
primitive neuroectodermal tumor of the CNS30 / 125680238
prostate cancer5 / 10268048
retinoblastoma5 / 46356107
skin tumor50 / 124949400
soft tissue/muscle tissue tumor17 / 125191135
uterine tumor14 / 90257155
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder4 / 29757134
blood11 / 12347889
bone9 / 71655125
bone marrow0 / 488010 
brain58 / 110098952
cervix7 / 48171145
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue22 / 215722101
esophagus0 / 202090 
eye18 / 21105485
heart3 / 8962633
intestine25 / 234472106
kidney13 / 21177761
larynx8 / 24145331
liver6 / 20774328
lung29 / 33697486
lymph1 / 4427022
lymph node5 / 9161054
mammary gland12 / 15327178
mouth9 / 67052134
muscle13 / 107715120
nerve3 / 15768190
ovary9 / 10205188
pancreas24 / 214812111
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland2 / 16585120
placenta27 / 28082596
prostate8 / 18934542
salivary gland1 / 2015549
skin55 / 210574261
spleen6 / 53952111
stomach7 / 9661972
testis16 / 33044248
thymus1 / 8113112
thyroid2 / 4747342
tonsil2 / 16999117
trachea1 / 5241319
umbilical cord2 / 13680146
uterus21 / 23287890
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210428_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts146.55
Adipocyte51.15
AdrenalCortex79.85
Adrenalgland56.9
Amygdala120.75
Appendix17.1
AtrioventricularNode16.15
BDCA4+_DentriticCells164.3
Bonemarrow31.1
BronchialEpithelialCells84.9
CD105+_Endothelial92.7
CD14+_Monocytes181.3
CD19+_BCells(neg._sel.)130.55
CD33+_Myeloid318.55
CD34+170.65
CD4+_Tcells209.25
CD56+_NKCells205.15
CD71+_EarlyErythroid85.6
CD8+_Tcells216.35
CardiacMyocytes79.7
Caudatenucleus56.15
Cerebellum49.95
CerebellumPeduncles68
CiliaryGanglion16.45
CingulateCortex104.6
Colorectaladenocarcinoma293.5
DorsalRootGanglion19.2
FetalThyroid42.15
Fetalbrain84.15
Fetalliver11.6
Fetallung48.95
GlobusPallidus35.15
Heart60.45
Hypothalamus68.75
Kidney28.3
Leukemia_chronicMyelogenousK-56291.65
Leukemia_promyelocytic-HL-6082.7
Leukemialymphoblastic(MOLT-4)108.55
Liver33.5
Lung158.45
Lymphnode62.25
Lymphoma_burkitts(Daudi)25.3
Lymphoma_burkitts(Raji)240.9
MedullaOblongata49.35
OccipitalLobe45.6
OlfactoryBulb58.25
Ovary25.55
Pancreas43.05
PancreaticIslet76.2
ParietalLobe47.15
Pituitary39.75
Placenta66.95
Pons17.3
PrefrontalCortex207.8
Prostate111.35
Salivarygland15.25
SkeletalMuscle20.5
Skin17.2
SmoothMuscle114.4
Spinalcord84.7
SubthalamicNucleus61.55
SuperiorCervicalGanglion18.7
TemporalLobe50.1
Testis106.3
TestisGermCell121.55
TestisIntersitial90
TestisLeydigCell64.75
TestisSeminiferousTubule103.6
Thalamus49.6
Thymus60.65
Thyroid187.05
Tongue31.25
Tonsil43.75
Trachea17.65
TrigeminalGanglion26.55
Uterus38.1
UterusCorpus15.7
WholeBlood135.3
Wholebrain151.45
colon33.2
pineal_day121.26
pineal_night135.6
retina130.575
small_intestine36.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P125993
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.55 ± 0.33
Basal Forebrain6.47 ± 0.21
Basal Part of Pons6.7 ± 0.34
Cerebellar Cortex6.56 ± 0.35
Cerebellar Nuclei6.53 ± 0.44
Claustrum6.46 ± 0.29
Epithalamus6.33 ± 0.07
Frontal Lobe6.68 ± 0.35
Globus Pallidus6.22 ± 0.21
Hypothalamus6.56 ± 0.33
Insula6.54 ± 0.4
Limbic Lobe6.49 ± 0.34
Mesencephalon6.53 ± 0.31
Myelencephalon6.56 ± 0.36
Occipital Lobe6.36 ± 0.23
Parietal Lobe6.53 ± 0.29
Pontine Tegmentum6.43 ± 0.32
Striatum6.3 ± 0.27
Subthalamus6.52 ± 0.11
Temporal Lobe6.6 ± 0.28
Thalamus6.63 ± 0.24
White Matter6.53 ± 0.35
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
HgsCBCerebellum41.72
51.17
HgsCTXCerebral cortex92.38
78.83
HgsHIPHippocampal region46.25
58.12
HgsHPFHippocampal formation48.52
52.63
HgsHYHypothalamus32.69
27.3
HgsLSXLateral septal complex40.3
29.42
HgsMBMidbrain35.3
34.48
HgsMYMedulla52.25
61.26
HgsOLFOlfactory bulb79.62
78.65
HgsPPons37.93
45.51
HgsPALPallidum46.28
46.3
HgsRHPRetrohippocampal region52.84
45.49
HgssAMYStriatum-like amygdalar nuclei61.94
49.45
HgsSTRStriatum53.75
42.18
HgsSTRdStriatum dorsal region55.57
43.64
HgsSTRvStriatum ventral region53.45
41.91
HgsTHThalamus54.6
49.57
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
HGS_HUMAN_410 12 410 421 ALQNAVTTFVNR PRIDE
PAp00008149 11 211 221 VCEPCYEQLNR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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