AutismKB 2.0

Annotation Detail for EXO1


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Basic Information Top
Gene Symbol:EXO1 ( HEX1,hExoI )
Gene Full Name: exonuclease 1
Band: 1q43
Quick LinksEntrez ID:9156; OMIM: 606063; Uniprot ID:EXO1_HUMAN; ENSEMBL ID: ENSG00000174371; HGNC ID: 3511
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus18 / 56401231
neonate2 / 3109764
infant0 / 236200 
juvenile0 / 555560 
adult44 / 193912122
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor4 / 34366116
chondrosarcoma9 / 82823108
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor15 / 26384556
glioma2 / 10688318
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor2 / 9635920
lung tumor7 / 10312767
lymphoma2 / 7175527
non-neoplasia0 / 972500 
normal43 / 336030712
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer0 / 1026800 
retinoblastoma3 / 4635664
skin tumor10 / 12494980
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites2 / 4001549
bladder0 / 297570 
blood0 / 1234780 
bone9 / 71655125
bone marrow2 / 4880140
brain7 / 11009896
cervix4 / 4817183
connective tissue3 / 14925520
ear2 / 16212123
embryonic tissue7 / 21572232
esophagus0 / 202090 
eye3 / 21105414
heart2 / 8962622
intestine1 / 2344724
kidney3 / 21177714
larynx0 / 241450 
liver3 / 20774314
lung8 / 33697423
lymph0 / 442700 
lymph node2 / 9161021
mammary gland2 / 15327113
mouth2 / 6705229
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate0 / 1893450 
salivary gland2 / 2015599
skin12 / 21057456
spleen0 / 539520 
stomach2 / 9661920
testis21 / 33044263
thymus9 / 81131110
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204603_at
Cell line Expression level Expression bar
721_B_lymphoblasts14.95
Adipocyte8.05
AdrenalCortex8.5
Adrenalgland9.2
Amygdala8.15
Appendix9.4
AtrioventricularNode7.75
BDCA4+_DentriticCells7.2
Bonemarrow9.95
BronchialEpithelialCells6.55
CD105+_Endothelial8.5
CD14+_Monocytes6.45
CD19+_BCells(neg._sel.)7.1
CD33+_Myeloid9.1
CD34+10.05
CD4+_Tcells7.45
CD56+_NKCells8.2
CD71+_EarlyErythroid9.45
CD8+_Tcells6.2
CardiacMyocytes11.7
Caudatenucleus7.8
Cerebellum6.45
CerebellumPeduncles9.8
CiliaryGanglion5.75
CingulateCortex8.9
Colorectaladenocarcinoma7.9
DorsalRootGanglion6.75
FetalThyroid7.85
Fetalbrain7.9
Fetalliver10.85
Fetallung6.25
GlobusPallidus6
Heart10.75
Hypothalamus8.25
Kidney8.05
Leukemia_chronicMyelogenousK-56213.95
Leukemia_promyelocytic-HL-608
Leukemialymphoblastic(MOLT-4)11.65
Liver11.9
Lung8.35
Lymphnode7.35
Lymphoma_burkitts(Daudi)12.05
Lymphoma_burkitts(Raji)11
MedullaOblongata7.25
OccipitalLobe7.15
OlfactoryBulb6.1
Ovary5.75
Pancreas6.35
PancreaticIslet8.6
ParietalLobe9.85
Pituitary9.2
Placenta7.9
Pons7.85
PrefrontalCortex9.5
Prostate8.9
Salivarygland6.5
SkeletalMuscle10.15
Skin6.55
SmoothMuscle8.5
Spinalcord8.55
SubthalamicNucleus7.5
SuperiorCervicalGanglion11.5
TemporalLobe7.3
Testis6.95
TestisGermCell6.2
TestisIntersitial6.95
TestisLeydigCell8.05
TestisSeminiferousTubule6.85
Thalamus8.1
Thymus5.95
Thyroid11
Tongue8.7
Tonsil7.8
Trachea6.7
TrigeminalGanglion9.9
Uterus6.1
UterusCorpus10.95
WholeBlood7.7
Wholebrain6.2
colon7.9
pineal_day8.68
pineal_night8.18
retina9.65
small_intestine7.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14435_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.82 ± 0.9
Basal Forebrain2.3 ± 0.55
Basal Part of Pons2 ± 0.45
Cerebellar Cortex1.94 ± 0.56
Cerebellar Nuclei3.07 ± 0.38
Claustrum3.18 ± 0.72
Epithalamus2.04 ± 0.98
Frontal Lobe2.29 ± 0.68
Globus Pallidus2.18 ± 0.46
Hypothalamus2.25 ± 0.57
Insula2.19 ± 0.9
Limbic Lobe2.56 ± 0.7
Mesencephalon2.51 ± 0.69
Myelencephalon2.46 ± 0.68
Occipital Lobe2.55 ± 0.81
Parietal Lobe2.64 ± 0.66
Pontine Tegmentum2.6 ± 0.75
Striatum2.72 ± 0.76
Subthalamus2.67 ± 0.27
Temporal Lobe2.46 ± 0.74
Thalamus2.27 ± 0.65
White Matter2.06 ± 0.32
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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