AutismKB 2.0

Annotation Detail for YTHDC1


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Basic Information Top
Gene Symbol:YTHDC1 ( KIAA1966,YT521,YT521-B )
Gene Full Name: YTH domain containing 1
Band: 4q13.2
Quick LinksEntrez ID:91746; OMIM: NA; Uniprot ID:YTDC1_HUMAN; ENSEMBL ID: ENSG00000083896; HGNC ID: 30626
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst7 / 62319112
fetus49 / 56401286
neonate1 / 3109732
infant1 / 2362042
juvenile4 / 5555671
adult134 / 193912169
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor5 / 9417853
cervical tumor1 / 3436629
chondrosarcoma6 / 8282372
colorectal tumor9 / 11424678
esophageal tumor2 / 17290115
gastrointestinal tumor7 / 11936958
germ cell tumor23 / 26384587
glioma1 / 1068839
head and neck tumor8 / 13630258
kidney tumor6 / 6895987
leukemia9 / 9584293
liver tumor8 / 9635983
lung tumor3 / 10312729
lymphoma1 / 7175513
non-neoplasia3 / 9725030
normal251 / 336030774
ovarian tumor6 / 7668278
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor5 / 12494940
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor10 / 90257110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder5 / 29757168
blood4 / 12347832
bone5 / 7165569
bone marrow2 / 4880140
brain46 / 110098941
cervix1 / 4817120
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue15 / 21572269
esophagus2 / 2020998
eye17 / 21105480
heart8 / 8962689
intestine17 / 23447272
kidney24 / 211777113
larynx1 / 2414541
liver16 / 20774377
lung14 / 33697441
lymph1 / 4427022
lymph node11 / 91610120
mammary gland5 / 15327132
mouth5 / 6705274
muscle1 / 1077159
nerve2 / 15768126
ovary7 / 10205168
pancreas14 / 21481265
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland2 / 16585120
placenta23 / 28082581
prostate10 / 18934552
salivary gland1 / 2015549
skin8 / 21057437
spleen1 / 5395218
stomach8 / 9661982
testis23 / 33044269
thymus12 / 81131147
thyroid3 / 4747363
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord0 / 136800 
uterus27 / 232878115
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212455_at
Cell line Expression level Expression bar
721_B_lymphoblasts624.4
Adipocyte79.5
AdrenalCortex105.35
Adrenalgland51.65
Amygdala312.75
Appendix166.05
AtrioventricularNode56.6
BDCA4+_DentriticCells640.2
Bonemarrow90
BronchialEpithelialCells182.85
CD105+_Endothelial232.4
CD14+_Monocytes277.5
CD19+_BCells(neg._sel.)799.7
CD33+_Myeloid747.65
CD34+678.05
CD4+_Tcells1163
CD56+_NKCells756.25
CD71+_EarlyErythroid278.85
CD8+_Tcells1145.7
CardiacMyocytes57.85
Caudatenucleus219.1
Cerebellum169.55
CerebellumPeduncles241.5
CiliaryGanglion41.25
CingulateCortex212.4
Colorectaladenocarcinoma86
DorsalRootGanglion99.05
FetalThyroid149.75
Fetalbrain434.75
Fetalliver163.3
Fetallung423.6
GlobusPallidus88.05
Heart16.75
Hypothalamus376.3
Kidney42.05
Leukemia_chronicMyelogenousK-562183.8
Leukemia_promyelocytic-HL-60267.2
Leukemialymphoblastic(MOLT-4)323.2
Liver13.1
Lung101.45
Lymphnode441.45
Lymphoma_burkitts(Daudi)263.3
Lymphoma_burkitts(Raji)239.6
MedullaOblongata198.55
OccipitalLobe295.75
OlfactoryBulb296
Ovary153.3
Pancreas131.95
PancreaticIslet305.4
ParietalLobe177.85
Pituitary379.75
Placenta299.95
Pons101.15
PrefrontalCortex691.8
Prostate175.15
Salivarygland297
SkeletalMuscle52.7
Skin86.1
SmoothMuscle94.9
Spinalcord297.35
SubthalamicNucleus127.6
SuperiorCervicalGanglion98.3
TemporalLobe103.15
Testis132
TestisGermCell261.45
TestisIntersitial159
TestisLeydigCell124.6
TestisSeminiferousTubule123.05
Thalamus178.7
Thymus373.1
Thyroid459.75
Tongue84.7
Tonsil254.65
Trachea229.7
TrigeminalGanglion48.25
Uterus375.55
UterusCorpus110.75
WholeBlood753.1
Wholebrain180.65
colon341
pineal_day770.44
pineal_night710.44
retina635.275
small_intestine322.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P352697
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.78 ± 0.52
Basal Forebrain4.99 ± 0.36
Basal Part of Pons5.52 ± 0.46
Cerebellar Cortex5.61 ± 0.18
Cerebellar Nuclei4.86 ± 0.61
Claustrum4.53 ± 0.81
Epithalamus4.54 ± 0.64
Frontal Lobe5.11 ± 0.49
Globus Pallidus3.83 ± 0.46
Hypothalamus5.2 ± 0.66
Insula5.15 ± 0.45
Limbic Lobe4.91 ± 0.61
Mesencephalon4.94 ± 0.61
Myelencephalon4.97 ± 0.59
Occipital Lobe5.24 ± 0.46
Parietal Lobe5.16 ± 0.58
Pontine Tegmentum5.05 ± 0.6
Striatum4.61 ± 0.54
Subthalamus5.49 ± 0.24
Temporal Lobe5.09 ± 0.48
Thalamus4.98 ± 0.49
White Matter3.51 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
A730098D12RikCBCerebellum50.86
63.61
A730098D12RikCTXCerebral cortex93.84
76.31
A730098D12RikHIPHippocampal region41.98
62.63
A730098D12RikHPFHippocampal formation38.27
47.8
A730098D12RikHYHypothalamus54.87
43.2
A730098D12RikLSXLateral septal complex87.3
68.33
A730098D12RikMBMidbrain36.28
30.71
A730098D12RikMYMedulla50.02
49.74
A730098D12RikOLFOlfactory bulb86.86
80.7
A730098D12RikPPons33.88
31.76
A730098D12RikPALPallidum58.88
52.18
A730098D12RikRHPRetrohippocampal region30.2
23.15
A730098D12RiksAMYStriatum-like amygdalar nuclei44.37
34.91
A730098D12RikSTRStriatum80.25
61.47
A730098D12RikSTRdStriatum dorsal region82.12
62.67
A730098D12RikSTRvStriatum ventral region91.97
69.3
A730098D12RikTHThalamus57.75
48.48
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00473898 15 458 472 SAHLTNPWNEHKPVK Peptide Atlas
YTDC1_HUMAN_306 9 306 314 GISPIVFDR PRIDE
YTDC1_HUMAN_60 8 60 67 QKPSVHSR PRIDE
YTDC1_HUMAN_9 8 9 16 QKPSVHSR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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