AutismKB 2.0

Annotation Detail for MAP3K13


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Basic Information Top
Gene Symbol:MAP3K13 ( LZK,MEKK13,MGC133196 )
Gene Full Name: mitogen-activated protein kinase kinase kinase 13
Band: 3q27.2
Quick LinksEntrez ID:9175; OMIM: 604915; Uniprot ID:M3K13_HUMAN; ENSEMBL ID: ENSG00000073803; HGNC ID: 6852
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus14 / 56401224
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult13 / 19391216
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor4 / 13630229
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal38 / 336030711
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain23 / 110098920
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine1 / 2344724
kidney3 / 21177714
larynx0 / 241450 
liver1 / 2077434
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth4 / 6705259
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach2 / 9661920
testis6 / 33044218
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211083_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.35
Adipocyte6.5
AdrenalCortex7.9
Adrenalgland5.9
Amygdala6.75
Appendix7.55
AtrioventricularNode6.2
BDCA4+_DentriticCells6.95
Bonemarrow7.8
BronchialEpithelialCells6.45
CD105+_Endothelial6.55
CD14+_Monocytes7.05
CD19+_BCells(neg._sel.)6.95
CD33+_Myeloid8.2
CD34+7.9
CD4+_Tcells6.8
CD56+_NKCells7.35
CD71+_EarlyErythroid6.35
CD8+_Tcells5.9
CardiacMyocytes14.2
Caudatenucleus6
Cerebellum5.45
CerebellumPeduncles8
CiliaryGanglion5.3
CingulateCortex7.2
Colorectaladenocarcinoma6.65
DorsalRootGanglion5.8
FetalThyroid6.55
Fetalbrain6.25
Fetalliver5.85
Fetallung5.05
GlobusPallidus5.2
Heart10.15
Hypothalamus6.95
Kidney5.95
Leukemia_chronicMyelogenousK-5626.05
Leukemia_promyelocytic-HL-605.9
Leukemialymphoblastic(MOLT-4)5.05
Liver10.55
Lung7.25
Lymphnode5.5
Lymphoma_burkitts(Daudi)8.75
Lymphoma_burkitts(Raji)10.05
MedullaOblongata5.95
OccipitalLobe5.9
OlfactoryBulb5.1
Ovary4.75
Pancreas5.55
PancreaticIslet7.4
ParietalLobe7.45
Pituitary7.65
Placenta6.5
Pons6.55
PrefrontalCortex7.9
Prostate7.7
Salivarygland5.5
SkeletalMuscle9.8
Skin5.75
SmoothMuscle7.5
Spinalcord7.15
SubthalamicNucleus6.4
SuperiorCervicalGanglion9.2
TemporalLobe6.25
Testis5.7
TestisGermCell5.3
TestisIntersitial5.9
TestisLeydigCell7.1
TestisSeminiferousTubule5.65
Thalamus6.95
Thymus5.15
Thyroid8.1
Tongue7.1
Tonsil6.55
Trachea5.5
TrigeminalGanglion7.85
Uterus5.4
UterusCorpus6.5
WholeBlood7.1
Wholebrain5.35
colon6.75
pineal_day8.16
pineal_night7.96
retina8.025
small_intestine6.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P85537
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.22 ± 0.71
Basal Forebrain4.28 ± 1.11
Basal Part of Pons4.06 ± 0.43
Cerebellar Cortex3.98 ± 0.56
Cerebellar Nuclei4.13 ± 0.52
Claustrum3.84 ± 0.64
Epithalamus3.6 ± 0.7
Frontal Lobe3.99 ± 0.53
Globus Pallidus3.7 ± 0.49
Hypothalamus4.12 ± 0.69
Insula4.12 ± 0.38
Limbic Lobe4.04 ± 0.53
Mesencephalon4.12 ± 0.54
Myelencephalon4.04 ± 0.54
Occipital Lobe4.59 ± 0.43
Parietal Lobe4.19 ± 0.59
Pontine Tegmentum4.16 ± 0.76
Striatum4.19 ± 0.57
Subthalamus4.28 ± 0.23
Temporal Lobe4.04 ± 0.58
Thalamus3.89 ± 0.51
White Matter3.68 ± 0.19
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Map3k13CBCerebellum2.05
2.67
Map3k13CTXCerebral cortex4.68
2.99
Map3k13HIPHippocampal region2.75
2.56
Map3k13HPFHippocampal formation3.75
3.21
Map3k13HYHypothalamus0.76
0.64
Map3k13LSXLateral septal complex0.2
0.13
Map3k13MBMidbrain1.45
2.03
Map3k13MYMedulla4.13
4.98
Map3k13OLFOlfactory bulb5.68
3.83
Map3k13PPons3.17
3.67
Map3k13PALPallidum1.56
1.33
Map3k13RHPRetrohippocampal region5.23
3.97
Map3k13sAMYStriatum-like amygdalar nuclei2.81
1.88
Map3k13STRStriatum1.84
1.19
Map3k13STRdStriatum dorsal region1.55
1.03
Map3k13STRvStriatum ventral region3.1
1.77
Map3k13THThalamus1.49
1.14
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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