AutismKB 2.0

Annotation Detail for BUB3


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Basic Information Top
Gene Symbol:BUB3 ( BUB3L,hBUB3 )
Gene Full Name: budding uninhibited by benzimidazoles 3 homolog (yeast)
Band: 10q26.13
Quick LinksEntrez ID:9184; OMIM: 603719; Uniprot ID:BUB3_HUMAN; ENSEMBL ID: ENSG00000154473; HGNC ID: 1151
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst21 / 62319336
fetus65 / 564012115
neonate5 / 31097160
infant6 / 23620254
juvenile3 / 5555653
adult196 / 1939121101
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor5 / 12794390
bladder carcinoma5 / 17475286
breast (mammary gland) tumor16 / 94178169
cervical tumor2 / 3436658
chondrosarcoma8 / 8282396
colorectal tumor21 / 114246183
esophageal tumor1 / 1729057
gastrointestinal tumor15 / 119369125
germ cell tumor36 / 263845136
glioma9 / 10688384
head and neck tumor26 / 136302190
kidney tumor8 / 68959116
leukemia13 / 95842135
liver tumor20 / 96359207
lung tumor17 / 103127164
lymphoma11 / 71755153
non-neoplasia8 / 9725082
normal389 / 3360307115
ovarian tumor12 / 76682156
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS20 / 125680159
prostate cancer6 / 10268058
retinoblastoma6 / 46356129
skin tumor17 / 124949136
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland8 / 33197240
ascites5 / 40015124
bladder9 / 29757302
blood15 / 123478121
bone8 / 71655111
bone marrow15 / 48801307
brain169 / 1100989153
cervix2 / 4817141
connective tissue17 / 149255113
ear1 / 1621261
embryonic tissue43 / 215722199
esophagus1 / 2020949
eye20 / 21105494
heart9 / 89626100
intestine27 / 234472115
kidney19 / 21177789
larynx0 / 241450 
liver26 / 207743125
lung38 / 336974112
lymph5 / 44270112
lymph node29 / 91610316
mammary gland20 / 153271130
mouth22 / 67052328
muscle7 / 10771564
nerve3 / 15768190
ovary15 / 102051146
pancreas7 / 21481232
parathyroid3 / 20539146
pharynx22 / 41328532
pituitary gland0 / 165850 
placenta19 / 28082567
prostate13 / 18934568
salivary gland4 / 20155198
skin25 / 210574118
spleen7 / 53952129
stomach14 / 96619144
testis67 / 330442202
thymus14 / 81131172
thyroid2 / 4747342
tonsil0 / 169990 
trachea8 / 52413152
umbilical cord2 / 13680146
uterus25 / 232878107
vascular9 / 51780173
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201456_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts140.8
Adipocyte8.95
AdrenalCortex9.2
Adrenalgland7.6
Amygdala12.85
Appendix8.6
AtrioventricularNode6.2
BDCA4+_DentriticCells51.25
Bonemarrow8.65
BronchialEpithelialCells42.1
CD105+_Endothelial62.6
CD14+_Monocytes9.65
CD19+_BCells(neg._sel.)57.35
CD33+_Myeloid11.65
CD34+76.35
CD4+_Tcells87.35
CD56+_NKCells105.15
CD71+_EarlyErythroid12.9
CD8+_Tcells76.05
CardiacMyocytes18.75
Caudatenucleus7.95
Cerebellum6.9
CerebellumPeduncles9.25
CiliaryGanglion5.75
CingulateCortex8.8
Colorectaladenocarcinoma51.65
DorsalRootGanglion6.3
FetalThyroid8.35
Fetalbrain9.1
Fetalliver12.2
Fetallung7.65
GlobusPallidus6.15
Heart10.25
Hypothalamus19.6
Kidney6.95
Leukemia_chronicMyelogenousK-56234.8
Leukemia_promyelocytic-HL-6043.95
Leukemialymphoblastic(MOLT-4)72.7
Liver11.25
Lung9.15
Lymphnode29.1
Lymphoma_burkitts(Daudi)78.3
Lymphoma_burkitts(Raji)13.15
MedullaOblongata7.65
OccipitalLobe8.35
OlfactoryBulb6.9
Ovary5.5
Pancreas8.25
PancreaticIslet8.8
ParietalLobe9.3
Pituitary15.6
Placenta9.5
Pons8.15
PrefrontalCortex11.95
Prostate11
Salivarygland7.1
SkeletalMuscle10
Skin6.55
SmoothMuscle13.55
Spinalcord9.45
SubthalamicNucleus7.2
SuperiorCervicalGanglion9.55
TemporalLobe7.55
Testis7.2
TestisGermCell7.65
TestisIntersitial6.9
TestisLeydigCell8.45
TestisSeminiferousTubule7.05
Thalamus8.8
Thymus49.05
Thyroid13.7
Tongue8.35
Tonsil11.65
Trachea7.1
TrigeminalGanglion8.45
Uterus13.05
UterusCorpus8
WholeBlood19.55
Wholebrain8.8
colon20.9
pineal_day13.28
pineal_night13.24
retina10.775
small_intestine44.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P320658
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.59 ± 0.34
Basal Forebrain8.59 ± 0.14
Basal Part of Pons8.65 ± 0.18
Cerebellar Cortex8.94 ± 0.11
Cerebellar Nuclei8.92 ± 0.2
Claustrum8.76 ± 0.43
Epithalamus8.85 ± 0.23
Frontal Lobe8.72 ± 0.27
Globus Pallidus8.99 ± 0.31
Hypothalamus9.18 ± 0.54
Insula8.68 ± 0.36
Limbic Lobe8.69 ± 0.24
Mesencephalon8.85 ± 0.34
Myelencephalon8.71 ± 0.25
Occipital Lobe8.8 ± 0.25
Parietal Lobe8.7 ± 0.3
Pontine Tegmentum8.75 ± 0.25
Striatum8.65 ± 0.35
Subthalamus8.91 ± 0.26
Temporal Lobe8.66 ± 0.21
Thalamus8.75 ± 0.22
White Matter9.77 ± 0.1
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
BUB3_HUMAN_140 10 140 149 VYTLSVSGDR PRIDE
BUB3_HUMAN_315 14 315 328 QVTDAETKPKSPCT PRIDE
PAp00005063 30 51 80 LKYQHTGAVLDCAFYDPTHAWSGGLDHQLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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