AutismKB 2.0

Annotation Detail for DCLK1


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Basic Information Top
Gene Symbol:DCLK1 ( CL1,CLICK1,DCAMKL1,DCDC3A,DCLK,KIAA0369 )
Gene Full Name: doublecortin-like kinase 1
Band: 13q13.3
Quick LinksEntrez ID:9201; OMIM: 604742; Uniprot ID:DCLK1_HUMAN; ENSEMBL ID: ENSG00000133083; HGNC ID: 2700
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst4 / 6231964
fetus66 / 564012117
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult52 / 193912126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor32 / 263845121
glioma14 / 106883130
head and neck tumor0 / 1363020 
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia5 / 9725051
normal287 / 336030785
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain270 / 1100989245
cervix0 / 481710 
connective tissue0 / 1492550 
ear1 / 1621261
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye7 / 21105433
heart0 / 896260 
intestine3 / 23447212
kidney3 / 21177714
larynx0 / 241450 
liver0 / 2077430 
lung14 / 33697441
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle3 / 10771527
nerve2 / 15768126
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland3 / 16585180
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach1 / 9661910
testis13 / 33044239
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205399_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.65
Adipocyte41.35
AdrenalCortex5.95
Adrenalgland4.65
Amygdala1145.55
Appendix6
AtrioventricularNode4.45
BDCA4+_DentriticCells5.65
Bonemarrow5.6
BronchialEpithelialCells5.3
CD105+_Endothelial5.5
CD14+_Monocytes5.85
CD19+_BCells(neg._sel.)5.75
CD33+_Myeloid6.8
CD34+6.85
CD4+_Tcells5.95
CD56+_NKCells6.25
CD71+_EarlyErythroid5.25
CD8+_Tcells5.35
CardiacMyocytes7.55
Caudatenucleus237.8
Cerebellum78.8
CerebellumPeduncles53.7
CiliaryGanglion4.15
CingulateCortex242.65
Colorectaladenocarcinoma46.8
DorsalRootGanglion4.35
FetalThyroid5.65
Fetalbrain1379.3
Fetalliver4.8
Fetallung4.8
GlobusPallidus247.25
Heart7.3
Hypothalamus259.15
Kidney4.45
Leukemia_chronicMyelogenousK-5624.95
Leukemia_promyelocytic-HL-605
Leukemialymphoblastic(MOLT-4)4.2
Liver7.3
Lung6
Lymphnode5.05
Lymphoma_burkitts(Daudi)7.1
Lymphoma_burkitts(Raji)7.9
MedullaOblongata353.95
OccipitalLobe471.25
OlfactoryBulb5.75
Ovary3.85
Pancreas4.5
PancreaticIslet5.95
ParietalLobe372.15
Pituitary11.5
Placenta5.45
Pons167.65
PrefrontalCortex490.65
Prostate6.4
Salivarygland4.6
SkeletalMuscle6.45
Skin4.45
SmoothMuscle6.15
Spinalcord164.8
SubthalamicNucleus359.95
SuperiorCervicalGanglion7
TemporalLobe168.15
Testis4.7
TestisGermCell4.65
TestisIntersitial4.8
TestisLeydigCell5.6
TestisSeminiferousTubule4.7
Thalamus58.95
Thymus4.4
Thyroid7.2
Tongue5.5
Tonsil5.45
Trachea4.75
TrigeminalGanglion6.1
Uterus19.85
UterusCorpus5.1
WholeBlood5.85
Wholebrain652.8
colon5.7
pineal_day158.4
pineal_night230.12
retina33.2
small_intestine5.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P928627
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.37 ± 0.71
Basal Forebrain5.67 ± 0.78
Basal Part of Pons5.96 ± 0.79
Cerebellar Cortex5.96 ± 0.42
Cerebellar Nuclei5.52 ± 0.65
Claustrum6.72 ± 0.39
Epithalamus5.67 ± 0.54
Frontal Lobe6.29 ± 0.51
Globus Pallidus3.61 ± 0.93
Hypothalamus6.21 ± 0.57
Insula6.32 ± 0.33
Limbic Lobe6.31 ± 0.84
Mesencephalon6 ± 0.73
Myelencephalon5.86 ± 0.73
Occipital Lobe5.77 ± 0.91
Parietal Lobe6.11 ± 0.63
Pontine Tegmentum5.91 ± 0.85
Striatum5.05 ± 1.02
Subthalamus6.32 ± 0.58
Temporal Lobe6.29 ± 0.46
Thalamus5.27 ± 0.64
White Matter3.23 ± 1.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dcamkl1CBCerebellum2.59
2.96
Dcamkl1CTXCerebral cortex9.19
5.75
Dcamkl1HIPHippocampal region2.07
1.67
Dcamkl1HPFHippocampal formation2.47
1.88
Dcamkl1HYHypothalamus0.94
0.92
Dcamkl1LSXLateral septal complex2.54
1.96
Dcamkl1MBMidbrain1.9
2.22
Dcamkl1MYMedulla3.2
3.35
Dcamkl1OLFOlfactory bulb5.65
5.27
Dcamkl1PPons1.74
2.29
Dcamkl1PALPallidum0.86
0.58
Dcamkl1RHPRetrohippocampal region3.23
2.23
Dcamkl1sAMYStriatum-like amygdalar nuclei1.33
1.7
Dcamkl1STRStriatum2.67
1.75
Dcamkl1STRdStriatum dorsal region2.75
1.77
Dcamkl1STRvStriatum ventral region3.16
1.68
Dcamkl1THThalamus1.67
1.53
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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