AutismKB 2.0

Annotation Detail for DLG5


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DLG5 ( KIAA0583,LP-DLG,P-DLG5,PDLG )
Gene Full Name: discs, large homolog 5 (Drosophila)
Band: 10q22.3
Quick LinksEntrez ID:9231; OMIM: 604090; Uniprot ID:DLG5_HUMAN; ENSEMBL ID: ENSG00000151208; HGNC ID: 2904
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst8 / 62319128
fetus50 / 56401288
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult215 / 1939121110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor31 / 94178329
cervical tumor2 / 3436658
chondrosarcoma6 / 8282372
colorectal tumor14 / 114246122
esophageal tumor0 / 172900 
gastrointestinal tumor9 / 11936975
germ cell tumor10 / 26384537
glioma8 / 10688374
head and neck tumor23 / 136302168
kidney tumor1 / 6895914
leukemia3 / 9584231
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal240 / 336030771
ovarian tumor4 / 7668252
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer7 / 10268068
retinoblastoma3 / 4635664
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor15 / 90257166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood2 / 12347816
bone3 / 7165541
bone marrow1 / 4880120
brain58 / 110098952
cervix2 / 4817141
connective tissue5 / 14925533
ear1 / 1621261
embryonic tissue20 / 21572292
esophagus0 / 202090 
eye14 / 21105466
heart4 / 8962644
intestine20 / 23447285
kidney4 / 21177718
larynx2 / 2414582
liver6 / 20774328
lung32 / 33697494
lymph0 / 442700 
lymph node0 / 916100 
mammary gland36 / 153271234
mouth9 / 67052134
muscle8 / 10771574
nerve0 / 157680 
ovary5 / 10205148
pancreas10 / 21481246
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta60 / 280825213
prostate20 / 189345105
salivary gland9 / 20155446
skin5 / 21057423
spleen0 / 539520 
stomach7 / 9661972
testis13 / 33044239
thymus2 / 8113124
thyroid2 / 4747342
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord2 / 13680146
uterus26 / 232878111
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201681_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.3
Adipocyte28.4
AdrenalCortex427.3
Adrenalgland193.95
Amygdala15.6
Appendix19
AtrioventricularNode11.4
BDCA4+_DentriticCells7.85
Bonemarrow10.55
BronchialEpithelialCells117.8
CD105+_Endothelial9.45
CD14+_Monocytes7.45
CD19+_BCells(neg._sel.)9.4
CD33+_Myeloid11.85
CD34+11.75
CD4+_Tcells9.95
CD56+_NKCells36.3
CD71+_EarlyErythroid8.95
CD8+_Tcells8.9
CardiacMyocytes26.35
Caudatenucleus9.05
Cerebellum14.05
CerebellumPeduncles11.15
CiliaryGanglion8.3
CingulateCortex11.75
Colorectaladenocarcinoma76.3
DorsalRootGanglion10.5
FetalThyroid46.8
Fetalbrain450.15
Fetalliver11.45
Fetallung58.55
GlobusPallidus10.8
Heart12.95
Hypothalamus40.65
Kidney8.85
Leukemia_chronicMyelogenousK-56217.55
Leukemia_promyelocytic-HL-607.55
Leukemialymphoblastic(MOLT-4)13.55
Liver14.4
Lung15.35
Lymphnode8.2
Lymphoma_burkitts(Daudi)10.95
Lymphoma_burkitts(Raji)13.05
MedullaOblongata10.1
OccipitalLobe12.7
OlfactoryBulb18.55
Ovary10.35
Pancreas8.6
PancreaticIslet21.05
ParietalLobe10.3
Pituitary128.9
Placenta1499.35
Pons10.25
PrefrontalCortex14.2
Prostate162.2
Salivarygland12.6
SkeletalMuscle12.2
Skin30.75
SmoothMuscle61.25
Spinalcord31.55
SubthalamicNucleus10.65
SuperiorCervicalGanglion16.15
TemporalLobe9.05
Testis13.45
TestisGermCell23.55
TestisIntersitial8.7
TestisLeydigCell11.85
TestisSeminiferousTubule8.55
Thalamus11.95
Thymus12.25
Thyroid239.2
Tongue13
Tonsil12.6
Trachea28.1
TrigeminalGanglion13
Uterus110.05
UterusCorpus11.6
WholeBlood10.3
Wholebrain11.9
colon13.85
pineal_day77.6
pineal_night111.12
retina50
small_intestine28.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P161209
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.95 ± 0.47
Basal Forebrain5.76 ± 0.37
Basal Part of Pons5.88 ± 0.41
Cerebellar Cortex5.53 ± 0.44
Cerebellar Nuclei5.86 ± 0.39
Claustrum5.92 ± 0.57
Epithalamus5.71 ± 0.68
Frontal Lobe5.5 ± 0.44
Globus Pallidus6.4 ± 0.37
Hypothalamus5.75 ± 0.39
Insula5.55 ± 0.39
Limbic Lobe5.93 ± 0.63
Mesencephalon5.79 ± 0.51
Myelencephalon5.78 ± 0.52
Occipital Lobe6.42 ± 0.63
Parietal Lobe5.77 ± 0.48
Pontine Tegmentum5.47 ± 0.52
Striatum5.17 ± 0.62
Subthalamus5.08 ± 0.4
Temporal Lobe5.68 ± 0.47
Thalamus5.79 ± 0.4
White Matter6.56 ± 0.66
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dlg5CBCerebellum4.42
6.97
Dlg5CTXCerebral cortex23.59
17.74
Dlg5HIPHippocampal region12.98
13.55
Dlg5HPFHippocampal formation12.56
11.53
Dlg5HYHypothalamus5.56
4.14
Dlg5LSXLateral septal complex4.41
3.22
Dlg5MBMidbrain6.17
8.02
Dlg5MYMedulla3.05
4.21
Dlg5OLFOlfactory bulb14.2
10.45
Dlg5PPons2.15
2.38
Dlg5PALPallidum6.06
4.6
Dlg5RHPRetrohippocampal region11.76
8.55
Dlg5sAMYStriatum-like amygdalar nuclei14.22
9.98
Dlg5STRStriatum5.81
4.3
Dlg5STRdStriatum dorsal region4.37
3.59
Dlg5STRvStriatum ventral region6.87
4.47
Dlg5THThalamus22.61
27.09
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00096257 35 856 890 KEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASER Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved