AutismKB 2.0

Annotation Detail for ORAI3


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Basic Information Top
Gene Symbol:ORAI3 ( MGC13024,TMEM142C )
Gene Full Name: ORAI calcium release-activated calcium modulator 3
Band: 16p11.2
Quick LinksEntrez ID:93129; OMIM: 610930; Uniprot ID:ORAI3_HUMAN; ENSEMBL ID: ENSG00000175938; HGNC ID: 28185
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221864_at
Cell line Expression level Expression bar
721_B_lymphoblasts76.6
Adipocyte74.05
AdrenalCortex36.4
Adrenalgland77.5
Amygdala35.4
Appendix37.85
AtrioventricularNode27.7
BDCA4+_DentriticCells76.1
Bonemarrow113.65
BronchialEpithelialCells47.25
CD105+_Endothelial28.45
CD14+_Monocytes230.35
CD19+_BCells(neg._sel.)112.35
CD33+_Myeloid75.3
CD34+66.2
CD4+_Tcells26.15
CD56+_NKCells108.2
CD71+_EarlyErythroid21.85
CD8+_Tcells24.15
CardiacMyocytes26.3
Caudatenucleus45
Cerebellum50.9
CerebellumPeduncles56.05
CiliaryGanglion28.45
CingulateCortex43.3
Colorectaladenocarcinoma46.8
DorsalRootGanglion33.6
FetalThyroid97.95
Fetalbrain33
Fetalliver52.2
Fetallung59.85
GlobusPallidus27
Heart114.9
Hypothalamus31.75
Kidney90.1
Leukemia_chronicMyelogenousK-56245.15
Leukemia_promyelocytic-HL-6023.1
Leukemialymphoblastic(MOLT-4)21.65
Liver93.25
Lung170.55
Lymphnode64.65
Lymphoma_burkitts(Daudi)47.6
Lymphoma_burkitts(Raji)27.7
MedullaOblongata34.65
OccipitalLobe22.45
OlfactoryBulb42.6
Ovary29.55
Pancreas25
PancreaticIslet55.15
ParietalLobe42.85
Pituitary78.6
Placenta62.25
Pons37.45
PrefrontalCortex40.2
Prostate198.6
Salivarygland37.55
SkeletalMuscle41.4
Skin44.65
SmoothMuscle37.7
Spinalcord71.45
SubthalamicNucleus29.55
SuperiorCervicalGanglion53.4
TemporalLobe31.45
Testis110.05
TestisGermCell61.5
TestisIntersitial28.4
TestisLeydigCell41.4
TestisSeminiferousTubule50.9
Thalamus56.45
Thymus51.75
Thyroid61.05
Tongue36.1
Tonsil38.85
Trachea51.95
TrigeminalGanglion29.2
Uterus38.75
UterusCorpus36.8
WholeBlood170.45
Wholebrain27.1
colon30.3
pineal_day33.74
pineal_night29.64
retina78.85
small_intestine36.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9237_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.07 ± 0.45
Basal Forebrain5.12 ± 0.38
Basal Part of Pons5.1 ± 0.5
Cerebellar Cortex5.46 ± 0.4
Cerebellar Nuclei5.88 ± 0.45
Claustrum5.2 ± 0.74
Epithalamus4.94 ± 0.51
Frontal Lobe4.98 ± 0.54
Globus Pallidus5.55 ± 0.78
Hypothalamus4.75 ± 0.5
Insula5.09 ± 0.44
Limbic Lobe5.13 ± 0.6
Mesencephalon5.04 ± 0.55
Myelencephalon5.19 ± 0.56
Occipital Lobe5.37 ± 0.51
Parietal Lobe5.12 ± 0.48
Pontine Tegmentum5.12 ± 0.5
Striatum5.11 ± 0.57
Subthalamus4.78 ± 0.24
Temporal Lobe5.08 ± 0.57
Thalamus5.41 ± 0.43
White Matter4.9 ± 0.17
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tmem142cCBCerebellum19.35
36.54
Tmem142cCTXCerebral cortex10.62
8.34
Tmem142cHIPHippocampal region13.95
19.85
Tmem142cHPFHippocampal formation10.6
13.2
Tmem142cHYHypothalamus0.58
0.49
Tmem142cLSXLateral septal complex1.99
1.64
Tmem142cMBMidbrain2.99
3.02
Tmem142cMYMedulla6.34
6.96
Tmem142cOLFOlfactory bulb10.49
7.51
Tmem142cPPons4.68
5.32
Tmem142cPALPallidum1.21
1.05
Tmem142cRHPRetrohippocampal region4.51
3.63
Tmem142csAMYStriatum-like amygdalar nuclei3.79
2.5
Tmem142cSTRStriatum1.73
1.46
Tmem142cSTRdStriatum dorsal region1.38
1.43
Tmem142cSTRvStriatum ventral region1.83
1.06
Tmem142cTHThalamus11.26
10.44
Peptide Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018