AutismKB 2.0

Annotation Detail for COPS2


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Basic Information Top
Gene Symbol:COPS2 ( ALIEN,CSN2,SGN2,TRIP15 )
Gene Full Name: COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
Band: 15q21.2
Quick LinksEntrez ID:9318; OMIM: 604508; Uniprot ID:CSN2_HUMAN; ENSEMBL ID: ENSG00000166200; HGNC ID: 30747
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body11 / 70761155
blastocyst5 / 6231980
fetus48 / 56401285
neonate5 / 31097160
infant6 / 23620254
juvenile3 / 5555653
adult155 / 193912179
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor7 / 9417874
cervical tumor9 / 34366261
chondrosarcoma6 / 8282372
colorectal tumor4 / 11424635
esophageal tumor5 / 17290289
gastrointestinal tumor4 / 11936933
germ cell tumor20 / 26384575
glioma4 / 10688337
head and neck tumor7 / 13630251
kidney tumor10 / 68959145
leukemia7 / 9584273
liver tumor4 / 9635941
lung tumor2 / 10312719
lymphoma3 / 7175541
non-neoplasia7 / 9725071
normal348 / 3360307103
ovarian tumor3 / 7668239
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS18 / 125680143
prostate cancer18 / 102680175
retinoblastoma2 / 4635643
skin tumor10 / 12494980
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland4 / 33197120
ascites1 / 4001524
bladder4 / 29757134
blood4 / 12347832
bone9 / 71655125
bone marrow8 / 48801163
brain103 / 110098993
cervix9 / 48171186
connective tissue9 / 14925560
ear0 / 162120 
embryonic tissue27 / 215722125
esophagus5 / 20209247
eye22 / 211054104
heart8 / 8962689
intestine11 / 23447246
kidney20 / 21177794
larynx0 / 241450 
liver14 / 20774367
lung19 / 33697456
lymph1 / 4427022
lymph node8 / 9161087
mammary gland10 / 15327165
mouth2 / 6705229
muscle14 / 107715129
nerve0 / 157680 
ovary5 / 10205148
pancreas13 / 21481260
parathyroid2 / 2053997
pharynx3 / 4132872
pituitary gland3 / 16585180
placenta37 / 280825131
prostate24 / 189345126
salivary gland0 / 201550 
skin22 / 210574104
spleen4 / 5395274
stomach6 / 9661962
testis43 / 330442130
thymus10 / 81131123
thyroid5 / 47473105
tonsil0 / 169990 
trachea9 / 52413171
umbilical cord0 / 136800 
uterus25 / 232878107
vascular12 / 51780231
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209838_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.5
Adipocyte8.3
AdrenalCortex9.15
Adrenalgland7.3
Amygdala12.8
Appendix8.75
AtrioventricularNode7.25
BDCA4+_DentriticCells9.5
Bonemarrow8.5
BronchialEpithelialCells8.35
CD105+_Endothelial19.05
CD14+_Monocytes9.2
CD19+_BCells(neg._sel.)9.35
CD33+_Myeloid10.75
CD34+10.85
CD4+_Tcells9.05
CD56+_NKCells9.85
CD71+_EarlyErythroid10.8
CD8+_Tcells8.2
CardiacMyocytes11.3
Caudatenucleus7.95
Cerebellum6.9
CerebellumPeduncles10.7
CiliaryGanglion8.15
CingulateCortex9.15
Colorectaladenocarcinoma8.5
DorsalRootGanglion7.3
FetalThyroid8.5
Fetalbrain9
Fetalliver7.7
Fetallung6.9
GlobusPallidus6.85
Heart11.9
Hypothalamus9.85
Kidney7.05
Leukemia_chronicMyelogenousK-56216.95
Leukemia_promyelocytic-HL-607.7
Leukemialymphoblastic(MOLT-4)6.65
Liver11.6
Lung9
Lymphnode7.1
Lymphoma_burkitts(Daudi)11.25
Lymphoma_burkitts(Raji)12.75
MedullaOblongata8.05
OccipitalLobe13.55
OlfactoryBulb6.75
Ovary6.95
Pancreas7.05
PancreaticIslet9.3
ParietalLobe9.55
Pituitary10.05
Placenta8
Pons8.35
PrefrontalCortex11.45
Prostate9.9
Salivarygland7.1
SkeletalMuscle10.65
Skin6.85
SmoothMuscle9.95
Spinalcord9.3
SubthalamicNucleus14.4
SuperiorCervicalGanglion10.7
TemporalLobe8.35
Testis7.15
TestisGermCell7.25
TestisIntersitial7.25
TestisLeydigCell8.6
TestisSeminiferousTubule7.3
Thalamus10.1
Thymus6.35
Thyroid10.95
Tongue8.75
Tonsil8.25
Trachea6.85
TrigeminalGanglion10.35
Uterus6.9
UterusCorpus9.25
WholeBlood9.15
Wholebrain7.45
colon8.6
pineal_day13.34
pineal_night11.26
retina10.375
small_intestine8.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P26021
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.04 ± 0.2
Basal Forebrain9.87 ± 0.2
Basal Part of Pons10.08 ± 0.21
Cerebellar Cortex9.85 ± 0.25
Cerebellar Nuclei10.18 ± 0.28
Claustrum10.21 ± 0.23
Epithalamus9.74 ± 0.33
Frontal Lobe9.95 ± 0.27
Globus Pallidus10.13 ± 0.11
Hypothalamus10.13 ± 0.24
Insula9.91 ± 0.2
Limbic Lobe10.08 ± 0.28
Mesencephalon10.04 ± 0.3
Myelencephalon9.95 ± 0.25
Occipital Lobe10.12 ± 0.21
Parietal Lobe10.02 ± 0.25
Pontine Tegmentum10.01 ± 0.27
Striatum10.02 ± 0.22
Subthalamus10.22 ± 0.27
Temporal Lobe9.94 ± 0.22
Thalamus9.9 ± 0.2
White Matter10.71 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cops2CBCerebellum46.08
85.22
Cops2CTXCerebral cortex100
100
Cops2HIPHippocampal region89.6
100
Cops2HPFHippocampal formation100
100
Cops2HYHypothalamus100
100
Cops2LSXLateral septal complex100
100
Cops2MBMidbrain88.47
100
Cops2MYMedulla80.33
100
Cops2OLFOlfactory bulb100
100
Cops2PPons71.44
100
Cops2PALPallidum82.9
100
Cops2RHPRetrohippocampal region100
100
Cops2sAMYStriatum-like amygdalar nuclei100
100
Cops2STRStriatum92.13
85.01
Cops2STRdStriatum dorsal region82.91
74.8
Cops2STRvStriatum ventral region100
100
Cops2THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CSN2_HUMAN_226 13 226 238 SAIPHPLIMGVIR PRIDE
CSN2_HUMAN_332 13 332 344 TNHSNIMDDPFIR PRIDE
PAp00063414 10 261 270 AHTDFFEAFK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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