AutismKB 2.0

Annotation Detail for CD22


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Basic Information Top
Gene Symbol:CD22 ( FLJ22814,MGC130020,SIGLEC-2,SIGLEC2 )
Gene Full Name: CD22 molecule
Band: 19q13.12
Quick LinksEntrez ID:933; OMIM: 107266; Uniprot ID:CD22_HUMAN; ENSEMBL ID: ENSG00000012124; HGNC ID: 1643
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus4 / 5640127
neonate4 / 31097128
infant0 / 236200 
juvenile9 / 55556161
adult29 / 193912114
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor16 / 26384560
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia8 / 9584283
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma40 / 71755557
non-neoplasia27 / 97250277
normal228 / 336030767
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood25 / 123478202
bone0 / 716550 
bone marrow1 / 4880120
brain19 / 110098917
cervix0 / 481710 
connective tissue26 / 149255174
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye1 / 2110544
heart1 / 8962611
intestine12 / 23447251
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung4 / 33697411
lymph29 / 44270655
lymph node60 / 91610654
mammary gland0 / 1532710 
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary1 / 1020519
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate5 / 18934526
salivary gland0 / 201550 
skin2 / 2105749
spleen88 / 539521631
stomach1 / 9661910
testis6 / 33044218
thymus12 / 81131147
thyroid1 / 4747321
tonsil22 / 169991294
trachea2 / 5241338
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 38521_at
Cell line Expression level Expression bar
721_B_lymphoblasts493.75
Adipocyte8.8
AdrenalCortex14.85
Adrenalgland6.6
Amygdala7.7
Appendix8.75
AtrioventricularNode12.4
BDCA4+_DentriticCells27.1
Bonemarrow8.1
BronchialEpithelialCells6.15
CD105+_Endothelial7.25
CD14+_Monocytes7.75
CD19+_BCells(neg._sel.)1172.95
CD33+_Myeloid10.15
CD34+15.3
CD4+_Tcells7.6
CD56+_NKCells13
CD71+_EarlyErythroid6.55
CD8+_Tcells6.65
CardiacMyocytes9.15
Caudatenucleus7.25
Cerebellum6.4
CerebellumPeduncles11.25
CiliaryGanglion12.75
CingulateCortex11.85
Colorectaladenocarcinoma6.4
DorsalRootGanglion10.5
FetalThyroid9.05
Fetalbrain9.7
Fetalliver6.85
Fetallung5.95
GlobusPallidus6.95
Heart8.7
Hypothalamus9.35
Kidney6.8
Leukemia_chronicMyelogenousK-56213.3
Leukemia_promyelocytic-HL-60348.05
Leukemialymphoblastic(MOLT-4)10.2
Liver9.75
Lung7.25
Lymphnode43.45
Lymphoma_burkitts(Daudi)642.55
Lymphoma_burkitts(Raji)1020.15
MedullaOblongata8.55
OccipitalLobe8
OlfactoryBulb7.2
Ovary8.7
Pancreas8.95
PancreaticIslet9.65
ParietalLobe10
Pituitary9.3
Placenta7.7
Pons8.55
PrefrontalCortex12.85
Prostate8.95
Salivarygland12.65
SkeletalMuscle13.4
Skin9.95
SmoothMuscle7.65
Spinalcord14.65
SubthalamicNucleus12.6
SuperiorCervicalGanglion12.2
TemporalLobe7.4
Testis7.1
TestisGermCell8.85
TestisIntersitial7.8
TestisLeydigCell8.9
TestisSeminiferousTubule16.2
Thalamus12.85
Thymus5.9
Thyroid7.7
Tongue9.1
Tonsil341.5
Trachea6.3
TrigeminalGanglion11.85
Uterus5.25
UterusCorpus7
WholeBlood8.6
Wholebrain5.9
colon5.65
pineal_day8.58
pineal_night8.38
retina11.85
small_intestine5.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15659_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.81 ± 1.02
Basal Forebrain1.72 ± 0.29
Basal Part of Pons1.14 ± 0.39
Cerebellar Cortex1.12 ± 0.48
Cerebellar Nuclei1.75 ± 0.75
Claustrum2.2 ± 0.8
Epithalamus1.2 ± 0.81
Frontal Lobe1.39 ± 0.78
Globus Pallidus3.09 ± 0.58
Hypothalamus1.57 ± 0.7
Insula1.28 ± 0.61
Limbic Lobe1.54 ± 0.73
Mesencephalon1.74 ± 0.82
Myelencephalon1.59 ± 0.8
Occipital Lobe1.58 ± 0.68
Parietal Lobe1.52 ± 0.78
Pontine Tegmentum1.64 ± 0.77
Striatum1.94 ± 0.77
Subthalamus1.61 ± 0.69
Temporal Lobe1.43 ± 0.73
Thalamus1.61 ± 0.64
White Matter4.24 ± 0.63
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cd22CBCerebellum1.29
1.17
Cd22CTXCerebral cortex1.24
1.12
Cd22HIPHippocampal region0.7
0.56
Cd22HPFHippocampal formation0.61
0.52
Cd22HYHypothalamus0.14
0.12
Cd22LSXLateral septal complex0.14
0.1
Cd22MBMidbrain0.33
0.36
Cd22MYMedulla2.06
1.56
Cd22OLFOlfactory bulb2.62
3.01
Cd22PPons1.25
1.17
Cd22PALPallidum0.5
0.55
Cd22RHPRetrohippocampal region0.44
0.45
Cd22sAMYStriatum-like amygdalar nuclei0.09
0.13
Cd22STRStriatum0.35
0.33
Cd22STRdStriatum dorsal region0.23
0.29
Cd22STRvStriatum ventral region0.91
0.61
Cd22THThalamus0.49
0.38
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00003894 25 513 537 IKPLSEIHSGNSVSLQCDFSSSHPK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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