AutismKB 2.0

Annotation Detail for SLIT2


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Basic Information Top
Gene Symbol:SLIT2 ( FLJ14420,SLIL3,Slit-2 )
Gene Full Name: slit homolog 2 (Drosophila)
Band: 4p15.31
Quick LinksEntrez ID:9353; OMIM: 603746; Uniprot ID:SLIT2_HUMAN; ENSEMBL ID: ENSG00000145147; HGNC ID: 11086
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst1 / 6231916
fetus27 / 56401247
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult34 / 193912117
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor8 / 26384530
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal84 / 336030724
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain20 / 110098918
cervix0 / 481710 
connective tissue4 / 14925526
ear2 / 16212123
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye2 / 2110549
heart5 / 8962655
intestine4 / 23447217
kidney7 / 21177733
larynx0 / 241450 
liver1 / 2077434
lung14 / 33697441
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas6 / 21481227
parathyroid1 / 2053948
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta4 / 28082514
prostate2 / 18934510
salivary gland0 / 201550 
skin1 / 2105744
spleen1 / 5395218
stomach1 / 9661910
testis6 / 33044218
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus11 / 23287847
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209897_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.15
Adipocyte51.05
AdrenalCortex123.95
Adrenalgland125.65
Amygdala39.9
Appendix20.05
AtrioventricularNode16.7
BDCA4+_DentriticCells12.05
Bonemarrow11.6
BronchialEpithelialCells12.2
CD105+_Endothelial13.9
CD14+_Monocytes12.4
CD19+_BCells(neg._sel.)14.75
CD33+_Myeloid15.95
CD34+18.25
CD4+_Tcells11.15
CD56+_NKCells12.95
CD71+_EarlyErythroid9
CD8+_Tcells10.15
CardiacMyocytes39.45
Caudatenucleus16.35
Cerebellum8.25
CerebellumPeduncles15.65
CiliaryGanglion17.3
CingulateCortex30.1
Colorectaladenocarcinoma11.5
DorsalRootGanglion83.4
FetalThyroid17.15
Fetalbrain27.7
Fetalliver10.25
Fetallung138.95
GlobusPallidus34.45
Heart18.25
Hypothalamus34.15
Kidney23.25
Leukemia_chronicMyelogenousK-56212.4
Leukemia_promyelocytic-HL-6012.7
Leukemialymphoblastic(MOLT-4)9.25
Liver17.5
Lung330.7
Lymphnode13.05
Lymphoma_burkitts(Daudi)15.3
Lymphoma_burkitts(Raji)17.5
MedullaOblongata25.75
OccipitalLobe25.6
OlfactoryBulb533.9
Ovary9.4
Pancreas11.25
PancreaticIslet17.4
ParietalLobe31.8
Pituitary62.35
Placenta17.15
Pons27.1
PrefrontalCortex73.35
Prostate73.15
Salivarygland8.15
SkeletalMuscle21.5
Skin10.75
SmoothMuscle120.95
Spinalcord14.75
SubthalamicNucleus35.95
SuperiorCervicalGanglion34.65
TemporalLobe30.15
Testis11.55
TestisGermCell12.35
TestisIntersitial12
TestisLeydigCell14.15
TestisSeminiferousTubule10.6
Thalamus13
Thymus12.25
Thyroid24.7
Tongue14.15
Tonsil12.05
Trachea25
TrigeminalGanglion19.45
Uterus126.25
UterusCorpus25.45
WholeBlood9.35
Wholebrain50.85
colon14.8
pineal_day52.82
pineal_night44.48
retina15.725
small_intestine14.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14951_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.54 ± 0.88
Basal Forebrain3.37 ± 0.39
Basal Part of Pons3.25 ± 0.38
Cerebellar Cortex2.99 ± 0.44
Cerebellar Nuclei3.65 ± 0.69
Claustrum3.51 ± 0.57
Epithalamus3.88 ± 0.86
Frontal Lobe3.76 ± 0.66
Globus Pallidus2.57 ± 1.06
Hypothalamus3.68 ± 0.59
Insula3.88 ± 0.54
Limbic Lobe3.64 ± 0.76
Mesencephalon3.93 ± 0.76
Myelencephalon3.64 ± 0.7
Occipital Lobe3.93 ± 0.58
Parietal Lobe3.74 ± 0.6
Pontine Tegmentum3.69 ± 0.62
Striatum3.69 ± 0.84
Subthalamus3.69 ± 0.84
Temporal Lobe3.75 ± 0.55
Thalamus3.33 ± 0.72
White Matter2.51 ± 0.22
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Slit2CBCerebellum2.95
4.08
Slit2CTXCerebral cortex12.82
9.41
Slit2HIPHippocampal region22.25
27.51
Slit2HPFHippocampal formation23.82
25.44
Slit2HYHypothalamus21.54
17.76
Slit2LSXLateral septal complex8.91
6.38
Slit2MBMidbrain8.89
8.06
Slit2MYMedulla20.56
20.77
Slit2OLFOlfactory bulb14.44
11.2
Slit2PPons13.8
13.03
Slit2PALPallidum4.53
3.48
Slit2RHPRetrohippocampal region27.54
23.25
Slit2sAMYStriatum-like amygdalar nuclei15.21
11.59
Slit2STRStriatum4.22
2.99
Slit2STRdStriatum dorsal region2.24
1.57
Slit2STRvStriatum ventral region3.52
2.06
Slit2THThalamus5.46
5.43
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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