AutismKB 2.0

Annotation Detail for LONP1


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Basic Information Top
Gene Symbol:LONP1 ( LON,LONP,LonHS,MGC1498,PIM1,PRSS15,hLON )
Gene Full Name: lon peptidase 1, mitochondrial
Band: 19p13.2
Quick LinksEntrez ID:9361; OMIM: 605490; Uniprot ID:LONM_HUMAN; ENSEMBL ID: ENSG00000196365; HGNC ID: 9479
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body12 / 70761169
blastocyst11 / 62319176
fetus60 / 564012106
neonate7 / 31097225
infant3 / 23620127
juvenile13 / 55556233
adult223 / 1939121115
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor9 / 9417895
cervical tumor13 / 34366378
chondrosarcoma13 / 82823156
colorectal tumor19 / 114246166
esophageal tumor1 / 1729057
gastrointestinal tumor36 / 119369301
germ cell tumor84 / 263845318
glioma18 / 106883168
head and neck tumor36 / 136302264
kidney tumor14 / 68959203
leukemia6 / 9584262
liver tumor41 / 96359425
lung tumor33 / 103127319
lymphoma38 / 71755529
non-neoplasia8 / 9725082
normal320 / 336030795
ovarian tumor15 / 76682195
pancreatic tumor10 / 10461695
primitive neuroectodermal tumor of the CNS28 / 125680222
prostate cancer17 / 102680165
retinoblastoma14 / 46356302
skin tumor66 / 124949528
soft tissue/muscle tissue tumor25 / 125191199
uterine tumor11 / 90257121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland12 / 33197361
ascites11 / 40015274
bladder1 / 2975733
blood17 / 123478137
bone6 / 7165583
bone marrow1 / 4880120
brain161 / 1100989146
cervix14 / 48171290
connective tissue15 / 149255100
ear0 / 162120 
embryonic tissue27 / 215722125
esophagus1 / 2020949
eye28 / 211054132
heart6 / 8962666
intestine35 / 234472149
kidney30 / 211777141
larynx0 / 241450 
liver44 / 207743211
lung58 / 336974172
lymph30 / 44270677
lymph node11 / 91610120
mammary gland10 / 15327165
mouth15 / 67052223
muscle12 / 107715111
nerve1 / 1576863
ovary20 / 102051195
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta37 / 280825131
prostate27 / 189345142
salivary gland10 / 20155496
skin80 / 210574379
spleen3 / 5395255
stomach6 / 9661962
testis67 / 330442202
thymus14 / 81131172
thyroid17 / 47473358
tonsil1 / 1699958
trachea8 / 52413152
umbilical cord2 / 13680146
uterus34 / 232878145
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209017_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts223.75
Adipocyte12.95
AdrenalCortex70.5
Adrenalgland200.75
Amygdala27
Appendix9.35
AtrioventricularNode7
BDCA4+_DentriticCells28.9
Bonemarrow9.85
BronchialEpithelialCells25.35
CD105+_Endothelial79.1
CD14+_Monocytes20.9
CD19+_BCells(neg._sel.)29.45
CD33+_Myeloid17.55
CD34+55.45
CD4+_Tcells25.4
CD56+_NKCells37.2
CD71+_EarlyErythroid19.3
CD8+_Tcells33.95
CardiacMyocytes52.45
Caudatenucleus12.7
Cerebellum8.3
CerebellumPeduncles13.1
CiliaryGanglion7.2
CingulateCortex14.85
Colorectaladenocarcinoma95.25
DorsalRootGanglion7.25
FetalThyroid11.6
Fetalbrain15.65
Fetalliver10.25
Fetallung18.1
GlobusPallidus7.7
Heart65.6
Hypothalamus18.6
Kidney9.65
Leukemia_chronicMyelogenousK-562331
Leukemia_promyelocytic-HL-6092.8
Leukemialymphoblastic(MOLT-4)34.95
Liver60.95
Lung74.9
Lymphnode13.45
Lymphoma_burkitts(Daudi)117.7
Lymphoma_burkitts(Raji)384.2
MedullaOblongata12.3
OccipitalLobe9.7
OlfactoryBulb7.75
Ovary6.85
Pancreas8.2
PancreaticIslet16.8
ParietalLobe9.9
Pituitary18.35
Placenta19.7
Pons9.9
PrefrontalCortex21.55
Prostate81.7
Salivarygland6.3
SkeletalMuscle13.05
Skin7.2
SmoothMuscle49.2
Spinalcord25.6
SubthalamicNucleus10.2
SuperiorCervicalGanglion11.55
TemporalLobe10.9
Testis15.75
TestisGermCell11
TestisIntersitial9.35
TestisLeydigCell9.9
TestisSeminiferousTubule8.4
Thalamus19.8
Thymus21.75
Thyroid75.95
Tongue10.4
Tonsil9.55
Trachea6.9
TrigeminalGanglion10.4
Uterus11.6
UterusCorpus10.45
WholeBlood9.6
Wholebrain53.9
colon11.1
pineal_day28.02
pineal_night25.34
retina16.875
small_intestine13.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12181_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.53 ± 0.63
Basal Forebrain5.85 ± 0.42
Basal Part of Pons6.47 ± 0.37
Cerebellar Cortex6.19 ± 0.59
Cerebellar Nuclei5.84 ± 0.45
Claustrum5.02 ± 0.84
Epithalamus5.94 ± 0.86
Frontal Lobe6.2 ± 0.54
Globus Pallidus5.9 ± 0.21
Hypothalamus5.92 ± 0.61
Insula6.12 ± 0.44
Limbic Lobe5.71 ± 0.67
Mesencephalon5.79 ± 0.62
Myelencephalon5.9 ± 0.64
Occipital Lobe5.39 ± 0.7
Parietal Lobe6.02 ± 0.53
Pontine Tegmentum5.98 ± 0.48
Striatum5.51 ± 0.5
Subthalamus6 ± 0.91
Temporal Lobe6.11 ± 0.48
Thalamus6.13 ± 0.51
White Matter5.59 ± 0.5
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Prss15CBCerebellum22.63
28.04
Prss15CTXCerebral cortex67.71
51.82
Prss15HIPHippocampal region41.59
58.3
Prss15HPFHippocampal formation46.63
52.81
Prss15HYHypothalamus24.45
19.41
Prss15LSXLateral septal complex46.75
33.29
Prss15MBMidbrain28.97
26.95
Prss15MYMedulla30.91
37.82
Prss15OLFOlfactory bulb54.75
44.96
Prss15PPons32.39
36.04
Prss15PALPallidum37.35
33.59
Prss15RHPRetrohippocampal region57.16
47.77
Prss15sAMYStriatum-like amygdalar nuclei37.09
26.55
Prss15STRStriatum38.03
27.7
Prss15STRdStriatum dorsal region32.9
24.11
Prss15STRvStriatum ventral region55.36
39.3
Prss15THThalamus52.43
45.45
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LONM_HUMAN_0 0 0 0 LSSDVLTLLIK PRIDE
LONM_HUMAN_219 18 219 236 QLEVEPEEPEAENKHKPR PRIDE
LONM_HUMAN_312 12 312 323 ESVLQMMQAGQR PRIDE
LONM_HUMAN_405 15 405 419 ELGLEKDDKDAIEEK PRIDE
LONM_HUMAN_459 13 459 471 NYLDWLTSIPWGK PRIDE
LONM_HUMAN_547 13 547 559 FSVGGMTDVAEIK PRIDE
LONM_HUMAN_690 11 690 700 LSSDVLTLLIK PRIDE
LONM_HUMAN_851 23 851 873 DGPSAGCTIVTALLSLAMGRPVR PRIDE
PAp00000506 9 680 688 ALCGLDESK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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