AutismKB 2.0

Annotation Detail for TBCK


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Basic Information Top
Gene Symbol:TBCK ( MGC16169,TBCKL )
Gene Full Name: TBC1 domain containing kinase
Band: 4q24
Quick LinksEntrez ID:93627; OMIM: NA; Uniprot ID:TBCK_HUMAN; ENSEMBL ID: ENSG00000145348; HGNC ID: 28261
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst1 / 6231916
fetus44 / 56401278
neonate2 / 3109764
infant1 / 2362042
juvenile2 / 5555635
adult66 / 193912134
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor2 / 11424617
esophageal tumor1 / 1729057
gastrointestinal tumor1 / 1193698
germ cell tumor15 / 26384556
glioma3 / 10688328
head and neck tumor3 / 13630222
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma6 / 7175583
non-neoplasia6 / 9725061
normal180 / 336030753
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone4 / 7165555
bone marrow0 / 488010 
brain79 / 110098971
cervix0 / 481710 
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus2 / 2020998
eye4 / 21105418
heart0 / 896260 
intestine2 / 2344728
kidney9 / 21177742
larynx0 / 241450 
liver6 / 20774328
lung7 / 33697420
lymph6 / 44270135
lymph node4 / 9161043
mammary gland2 / 15327113
mouth2 / 6705229
muscle8 / 10771574
nerve0 / 157680 
ovary2 / 10205119
pancreas3 / 21481213
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta12 / 28082542
prostate5 / 18934526
salivary gland0 / 201550 
skin2 / 2105749
spleen2 / 5395237
stomach1 / 9661910
testis42 / 330442127
thymus7 / 8113186
thyroid1 / 4747321
tonsil0 / 169990 
trachea20 / 52413381
umbilical cord1 / 1368073
uterus12 / 23287851
vascular1 / 5178019
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10622_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.81 ± 0.29
Basal Forebrain6.7 ± 0.15
Basal Part of Pons6.53 ± 0.3
Cerebellar Cortex6.94 ± 0.19
Cerebellar Nuclei6.22 ± 0.4
Claustrum6.71 ± 0.4
Epithalamus6.6 ± 0.27
Frontal Lobe6.58 ± 0.32
Globus Pallidus6.71 ± 0.22
Hypothalamus6.57 ± 0.41
Insula6.61 ± 0.26
Limbic Lobe6.77 ± 0.32
Mesencephalon6.71 ± 0.35
Myelencephalon6.66 ± 0.29
Occipital Lobe6.88 ± 0.31
Parietal Lobe6.73 ± 0.3
Pontine Tegmentum6.59 ± 0.37
Striatum6.49 ± 0.27
Subthalamus6.42 ± 0.31
Temporal Lobe6.73 ± 0.26
Thalamus6.61 ± 0.29
White Matter7.18 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
A630047E20RikPPons19.67
24.73
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018