AutismKB 2.0

Annotation Detail for NRXN3


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Basic Information Top
Gene Symbol:NRXN3 ( C14orf60,KIAA0743,MGC176711 )
Gene Full Name: neurexin 3
Band: 14q24.3-q31.1
Quick LinksEntrez ID:9369; OMIM: 600567; Uniprot ID:NRX3A_HUMAN; ENSEMBL ID: ENSG00000021645; HGNC ID: 8010
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus20 / 56401235
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult60 / 193912130
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor11 / 26384541
glioma0 / 1068830 
head and neck tumor14 / 136302102
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor3 / 9635931
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal130 / 336030738
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone2 / 7165527
bone marrow0 / 488010 
brain78 / 110098970
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye11 / 21105452
heart1 / 8962611
intestine0 / 2344720 
kidney4 / 21177718
larynx11 / 24145455
liver3 / 20774314
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth3 / 6705244
muscle2 / 10771518
nerve1 / 1576863
ovary0 / 1020510 
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate4 / 18934521
salivary gland0 / 201550 
skin2 / 2105749
spleen1 / 5395218
stomach3 / 9661931
testis15 / 33044245
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus5 / 23287821
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205795_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.05
Adipocyte4
AdrenalCortex4.3
Adrenalgland3.4
Amygdala4.35
Appendix4.35
AtrioventricularNode3.2
BDCA4+_DentriticCells4.45
Bonemarrow4
BronchialEpithelialCells4
CD105+_Endothelial4.15
CD14+_Monocytes4.35
CD19+_BCells(neg._sel.)4.35
CD33+_Myeloid5.25
CD34+5.1
CD4+_Tcells4.45
CD56+_NKCells4.85
CD71+_EarlyErythroid3.8
CD8+_Tcells3.9
CardiacMyocytes5.25
Caudatenucleus3.7
Cerebellum8.9
CerebellumPeduncles648.65
CiliaryGanglion2.9
CingulateCortex109.75
Colorectaladenocarcinoma4.05
DorsalRootGanglion3.25
FetalThyroid4
Fetalbrain4.35
Fetalliver3.5
Fetallung3.35
GlobusPallidus9.55
Heart5.15
Hypothalamus12.4
Kidney3.3
Leukemia_chronicMyelogenousK-5623.65
Leukemia_promyelocytic-HL-603.6
Leukemialymphoblastic(MOLT-4)3.35
Liver5.35
Lung4.55
Lymphnode3.45
Lymphoma_burkitts(Daudi)5.2
Lymphoma_burkitts(Raji)5.65
MedullaOblongata11.25
OccipitalLobe120.7
OlfactoryBulb45.65
Ovary2.7
Pancreas3.3
PancreaticIslet4.35
ParietalLobe31.7
Pituitary4.75
Placenta4.2
Pons12.7
PrefrontalCortex24.9
Prostate4.75
Salivarygland3.2
SkeletalMuscle4.7
Skin3.15
SmoothMuscle4.65
Spinalcord4.4
SubthalamicNucleus18
SuperiorCervicalGanglion4.65
TemporalLobe8.8
Testis3.5
TestisGermCell3.5
TestisIntersitial3.4
TestisLeydigCell4
TestisSeminiferousTubule3.55
Thalamus4.1
Thymus3.15
Thyroid5.05
Tongue4
Tonsil3.9
Trachea3.4
TrigeminalGanglion4.2
Uterus3.35
UterusCorpus3.65
WholeBlood4.4
Wholebrain10.25
colon4.1
pineal_day5.12
pineal_night5.02
retina5.1
small_intestine3.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P251841
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala11.05 ± 0.47
Basal Forebrain11.14 ± 0.1
Basal Part of Pons11.6 ± 0.2
Cerebellar Cortex11.55 ± 0.2
Cerebellar Nuclei10.57 ± 0.44
Claustrum11.13 ± 0.25
Epithalamus9.78 ± 0.59
Frontal Lobe11 ± 0.47
Globus Pallidus9.43 ± 0.59
Hypothalamus10.72 ± 0.97
Insula11.04 ± 0.25
Limbic Lobe11.03 ± 0.57
Mesencephalon10.86 ± 0.76
Myelencephalon10.8 ± 0.68
Occipital Lobe10.94 ± 0.39
Parietal Lobe10.88 ± 0.47
Pontine Tegmentum10.78 ± 0.55
Striatum10.19 ± 0.54
Subthalamus9.67 ± 0.41
Temporal Lobe11.05 ± 0.42
Thalamus10.94 ± 0.6
White Matter8.76 ± 0.7
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nrxn3CBCerebellum100
100
Nrxn3CTXCerebral cortex100
100
Nrxn3HIPHippocampal region100
100
Nrxn3HPFHippocampal formation100
100
Nrxn3HYHypothalamus100
100
Nrxn3LSXLateral septal complex100
100
Nrxn3MBMidbrain100
100
Nrxn3MYMedulla97.68
100
Nrxn3OLFOlfactory bulb100
100
Nrxn3PPons90.83
100
Nrxn3PALPallidum100
100
Nrxn3RHPRetrohippocampal region100
100
Nrxn3sAMYStriatum-like amygdalar nuclei100
100
Nrxn3STRStriatum100
100
Nrxn3STRdStriatum dorsal region100
100
Nrxn3STRvStriatum ventral region100
100
Nrxn3THThalamus92.89
92.91
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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