AutismKB 2.0

Annotation Detail for NRXN1


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Basic Information Top
Gene Symbol:NRXN1 ( DKFZp313P2036,FLJ35941,Hs.22998,KIAA0578,PTHSL2 )
Gene Full Name: neurexin 1
Band: 2p16.3
Quick LinksEntrez ID:9378; OMIM: 600565; Uniprot ID:NRX1A_HUMAN; ENSEMBL ID: ENSG00000179915; HGNC ID: 8008
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus49 / 56401286
neonate0 / 310970 
infant1 / 2362042
juvenile2 / 5555635
adult38 / 193912119
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor21 / 26384579
glioma7 / 10688365
head and neck tumor0 / 1363020 
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal165 / 336030749
ovarian tumor0 / 766820 
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor7 / 12494956
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain169 / 1100989153
cervix0 / 481710 
connective tissue1 / 1492556
ear3 / 16212185
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine3 / 23447212
kidney3 / 21177714
larynx0 / 241450 
liver1 / 2077434
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle5 / 10771546
nerve2 / 15768126
ovary0 / 1020510 
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin7 / 21057433
spleen0 / 539520 
stomach0 / 966190 
testis12 / 33044236
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus2 / 2328788
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209915_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.45
Adipocyte6.75
AdrenalCortex9.85
Adrenalgland6.55
Amygdala225.9
Appendix33.05
AtrioventricularNode8.55
BDCA4+_DentriticCells6.25
Bonemarrow7.65
BronchialEpithelialCells6.05
CD105+_Endothelial6.4
CD14+_Monocytes6.8
CD19+_BCells(neg._sel.)7.05
CD33+_Myeloid7.9
CD34+6.9
CD4+_Tcells6.3
CD56+_NKCells6.8
CD71+_EarlyErythroid6.2
CD8+_Tcells5.65
CardiacMyocytes8.3
Caudatenucleus25.55
Cerebellum34.3
CerebellumPeduncles53.4
CiliaryGanglion13.45
CingulateCortex71.6
Colorectaladenocarcinoma6.7
DorsalRootGanglion10.55
FetalThyroid6.9
Fetalbrain345.55
Fetalliver6.05
Fetallung5.4
GlobusPallidus115.35
Heart9.2
Hypothalamus70.15
Kidney6.85
Leukemia_chronicMyelogenousK-5626.15
Leukemia_promyelocytic-HL-606.25
Leukemialymphoblastic(MOLT-4)5.55
Liver10.95
Lung7.25
Lymphnode5.75
Lymphoma_burkitts(Daudi)9.3
Lymphoma_burkitts(Raji)9.15
MedullaOblongata91.15
OccipitalLobe150.05
OlfactoryBulb18.6
Ovary5.5
Pancreas5.65
PancreaticIslet7.4
ParietalLobe102.45
Pituitary9.9
Placenta6.5
Pons82.3
PrefrontalCortex132
Prostate7.75
Salivarygland6.15
SkeletalMuscle10.5
Skin9.05
SmoothMuscle7.5
Spinalcord8.6
SubthalamicNucleus83.55
SuperiorCervicalGanglion17.9
TemporalLobe66.05
Testis6.05
TestisGermCell5.7
TestisIntersitial5.8
TestisLeydigCell7.55
TestisSeminiferousTubule5.85
Thalamus87.7
Thymus4.95
Thyroid8.1
Tongue6.95
Tonsil6.9
Trachea5.9
TrigeminalGanglion8.75
Uterus5.25
UterusCorpus8.05
WholeBlood6.2
Wholebrain60.2
colon6.4
pineal_day20.72
pineal_night48.24
retina8.05
small_intestine6.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_484_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.97 ± 0.35
Basal Forebrain9.38 ± 0.19
Basal Part of Pons9.17 ± 0.21
Cerebellar Cortex9.81 ± 0.18
Cerebellar Nuclei8.77 ± 0.3
Claustrum9.4 ± 0.44
Epithalamus8.91 ± 0.59
Frontal Lobe9.34 ± 0.44
Globus Pallidus8.78 ± 0.17
Hypothalamus9.24 ± 0.62
Insula9.5 ± 0.35
Limbic Lobe9.54 ± 0.38
Mesencephalon9.39 ± 0.37
Myelencephalon9.38 ± 0.42
Occipital Lobe9.49 ± 0.41
Parietal Lobe9.43 ± 0.4
Pontine Tegmentum9.4 ± 0.51
Striatum8.7 ± 0.31
Subthalamus9.3 ± 0.17
Temporal Lobe9.52 ± 0.32
Thalamus9.65 ± 0.36
White Matter8.04 ± 0.22
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nrxn1CBCerebellum100
100
Nrxn1CTXCerebral cortex100
100
Nrxn1HIPHippocampal region89.27
100
Nrxn1HPFHippocampal formation100
100
Nrxn1HYHypothalamus100
100
Nrxn1LSXLateral septal complex100
100
Nrxn1MBMidbrain100
100
Nrxn1MYMedulla100
100
Nrxn1OLFOlfactory bulb100
100
Nrxn1PPons100
100
Nrxn1PALPallidum100
100
Nrxn1RHPRetrohippocampal region100
100
Nrxn1sAMYStriatum-like amygdalar nuclei100
100
Nrxn1STRStriatum75.34
73.89
Nrxn1STRdStriatum dorsal region56.18
53.71
Nrxn1STRvStriatum ventral region86.08
77.96
Nrxn1THThalamus100
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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