AutismKB 2.0

Annotation Detail for NRXN2


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Basic Information Top
Gene Symbol:NRXN2 ( FLJ40892,KIAA0921 )
Gene Full Name: neurexin 2
Band: 11q13.1
Quick LinksEntrez ID:9379; OMIM: 600566; Uniprot ID:NRX2A_HUMAN; ENSEMBL ID: ENSG00000110076; HGNC ID: 8009
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus8 / 56401214
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult34 / 193912117
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor9 / 26384534
glioma14 / 106883130
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal79 / 336030723
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone2 / 7165527
bone marrow1 / 4880120
brain63 / 110098957
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye26 / 211054123
heart0 / 896260 
intestine0 / 2344720 
kidney6 / 21177728
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin1 / 2105744
spleen1 / 5395218
stomach0 / 966190 
testis8 / 33044224
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209982_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.2
Adipocyte9.1
AdrenalCortex11.35
Adrenalgland7.55
Amygdala320.85
Appendix9.7
AtrioventricularNode9.55
BDCA4+_DentriticCells7.65
Bonemarrow9.35
BronchialEpithelialCells9.05
CD105+_Endothelial8.1
CD14+_Monocytes9.2
CD19+_BCells(neg._sel.)10.15
CD33+_Myeloid9.7
CD34+9.7
CD4+_Tcells8.75
CD56+_NKCells10.25
CD71+_EarlyErythroid7.55
CD8+_Tcells7
CardiacMyocytes16
Caudatenucleus21.3
Cerebellum123.35
CerebellumPeduncles219.25
CiliaryGanglion8.25
CingulateCortex80.8
Colorectaladenocarcinoma8.3
DorsalRootGanglion22.65
FetalThyroid8.05
Fetalbrain164.2
Fetalliver10.65
Fetallung6.25
GlobusPallidus19.25
Heart10.6
Hypothalamus37.4
Kidney9.7
Leukemia_chronicMyelogenousK-5628.05
Leukemia_promyelocytic-HL-608.5
Leukemialymphoblastic(MOLT-4)7.8
Liver17.65
Lung9
Lymphnode6.6
Lymphoma_burkitts(Daudi)11.5
Lymphoma_burkitts(Raji)13.4
MedullaOblongata25.55
OccipitalLobe37.2
OlfactoryBulb7.35
Ovary6.85
Pancreas9.2
PancreaticIslet10
ParietalLobe40.95
Pituitary19.2
Placenta7.35
Pons22.55
PrefrontalCortex66.55
Prostate8.7
Salivarygland9.2
SkeletalMuscle13.65
Skin9.8
SmoothMuscle9.2
Spinalcord19.6
SubthalamicNucleus46.9
SuperiorCervicalGanglion13.25
TemporalLobe58.6
Testis11
TestisGermCell9.6
TestisIntersitial9.05
TestisLeydigCell9.65
TestisSeminiferousTubule16.8
Thalamus26
Thymus5.45
Thyroid10.2
Tongue8.7
Tonsil7.95
Trachea8.65
TrigeminalGanglion10.75
Uterus7.4
UterusCorpus13.65
WholeBlood8.15
Wholebrain84.15
colon8.2
pineal_day10.68
pineal_night10.72
retina17.7
small_intestine7.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9846_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.86 ± 0.47
Basal Forebrain7.07 ± 0.38
Basal Part of Pons7.18 ± 0.4
Cerebellar Cortex7.74 ± 0.19
Cerebellar Nuclei6.81 ± 0.31
Claustrum7.74 ± 0.51
Epithalamus6.05 ± 0.79
Frontal Lobe7.05 ± 0.47
Globus Pallidus6.45 ± 0.48
Hypothalamus6.82 ± 0.55
Insula7.24 ± 0.43
Limbic Lobe7.51 ± 0.5
Mesencephalon7.03 ± 0.63
Myelencephalon7.19 ± 0.59
Occipital Lobe7.23 ± 0.39
Parietal Lobe7.18 ± 0.57
Pontine Tegmentum7.11 ± 0.46
Striatum6.37 ± 0.29
Subthalamus6.8 ± 0.2
Temporal Lobe7.42 ± 0.46
Thalamus7.34 ± 0.37
White Matter6.62 ± 0.58
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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