AutismKB 2.0

Annotation Detail for TGFBRAP1


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Basic Information Top
Gene Symbol:TGFBRAP1 ( TRAP-1,TRAP1 )
Gene Full Name: transforming growth factor, beta receptor associated protein 1
Band: 2q12.1-q12.2
Quick LinksEntrez ID:9392; OMIM: 606237; Uniprot ID:TGFA1_HUMAN; ENSEMBL ID: ENSG00000135966; HGNC ID: 16836
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus19 / 56401233
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult34 / 193912117
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor2 / 3436658
chondrosarcoma2 / 8282324
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor1 / 2638453
glioma1 / 1068839
head and neck tumor5 / 13630236
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor2 / 10312719
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal62 / 336030718
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer2 / 10268019
retinoblastoma2 / 4635643
skin tumor2 / 12494916
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow1 / 4880120
brain20 / 110098918
cervix2 / 4817141
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye7 / 21105433
heart0 / 896260 
intestine8 / 23447234
kidney1 / 2117774
larynx1 / 2414541
liver3 / 20774314
lung6 / 33697417
lymph1 / 4427022
lymph node3 / 9161032
mammary gland5 / 15327132
mouth4 / 6705259
muscle4 / 10771537
nerve0 / 157680 
ovary1 / 1020519
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate2 / 18934510
salivary gland0 / 201550 
skin4 / 21057418
spleen1 / 5395218
stomach0 / 966190 
testis0 / 3304420 
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205210_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.55
Adipocyte3.5
AdrenalCortex3.6
Adrenalgland2.95
Amygdala3.8
Appendix3.55
AtrioventricularNode2.6
BDCA4+_DentriticCells5.2
Bonemarrow3.5
BronchialEpithelialCells3.55
CD105+_Endothelial3.6
CD14+_Monocytes3.85
CD19+_BCells(neg._sel.)3.9
CD33+_Myeloid4.65
CD34+4.6
CD4+_Tcells4
CD56+_NKCells4.35
CD71+_EarlyErythroid3.3
CD8+_Tcells3.55
CardiacMyocytes4.35
Caudatenucleus3.15
Cerebellum2.9
CerebellumPeduncles4
CiliaryGanglion2.45
CingulateCortex3.6
Colorectaladenocarcinoma3.6
DorsalRootGanglion2.65
FetalThyroid3.45
Fetalbrain3.6
Fetalliver3.05
Fetallung2.95
GlobusPallidus2.6
Heart4.45
Hypothalamus3.95
Kidney2.85
Leukemia_chronicMyelogenousK-5623.2
Leukemia_promyelocytic-HL-603.1
Leukemialymphoblastic(MOLT-4)2.9
Liver4.7
Lung6
Lymphnode3.05
Lymphoma_burkitts(Daudi)4.5
Lymphoma_burkitts(Raji)4.85
MedullaOblongata3.25
OccipitalLobe3.2
OlfactoryBulb2.8
Ovary2.3
Pancreas2.8
PancreaticIslet3.8
ParietalLobe3.75
Pituitary4.15
Placenta3.75
Pons3.35
PrefrontalCortex4.5
Prostate4.2
Salivarygland2.8
SkeletalMuscle4.1
Skin2.65
SmoothMuscle4.05
Spinalcord3.8
SubthalamicNucleus3.2
SuperiorCervicalGanglion3.9
TemporalLobe3.2
Testis3.1
TestisGermCell2.95
TestisIntersitial2.95
TestisLeydigCell3.45
TestisSeminiferousTubule3.05
Thalamus3.6
Thymus2.85
Thyroid4.5
Tongue3.45
Tonsil3.45
Trachea3
TrigeminalGanglion3.4
Uterus2.95
UterusCorpus3.15
WholeBlood3.95
Wholebrain3.05
colon3.6
pineal_day4.44
pineal_night4.34
retina4.275
small_intestine3.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P120146
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.04 ± 0.37
Basal Forebrain7.07 ± 0.17
Basal Part of Pons7.29 ± 0.22
Cerebellar Cortex7.49 ± 0.19
Cerebellar Nuclei7.03 ± 0.28
Claustrum6.92 ± 0.37
Epithalamus7.21 ± 0.24
Frontal Lobe7.29 ± 0.31
Globus Pallidus6.7 ± 0.1
Hypothalamus7.16 ± 0.24
Insula7.32 ± 0.17
Limbic Lobe7.2 ± 0.38
Mesencephalon7.11 ± 0.32
Myelencephalon7.17 ± 0.33
Occipital Lobe7.26 ± 0.24
Parietal Lobe7.24 ± 0.32
Pontine Tegmentum7.22 ± 0.35
Striatum6.79 ± 0.27
Subthalamus7.2 ± 0.25
Temporal Lobe7.32 ± 0.26
Thalamus7.15 ± 0.3
White Matter7.26 ± 0.25
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tgfbrap1CBCerebellum5.64
6.49
Tgfbrap1CTXCerebral cortex9.85
6.59
Tgfbrap1HIPHippocampal region8.37
7.7
Tgfbrap1HPFHippocampal formation11.83
9.97
Tgfbrap1HYHypothalamus1.65
1.48
Tgfbrap1LSXLateral septal complex0.49
0.3
Tgfbrap1MBMidbrain2.24
1.85
Tgfbrap1MYMedulla10.47
11.19
Tgfbrap1OLFOlfactory bulb11.32
7.4
Tgfbrap1PPons4.86
4.47
Tgfbrap1PALPallidum3.25
2.51
Tgfbrap1RHPRetrohippocampal region18.98
14.15
Tgfbrap1sAMYStriatum-like amygdalar nuclei1.61
1.19
Tgfbrap1STRStriatum2.28
1.6
Tgfbrap1STRdStriatum dorsal region2.55
1.87
Tgfbrap1STRvStriatum ventral region2.67
1.59
Tgfbrap1THThalamus3.62
2.53
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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