AutismKB 2.0

Annotation Detail for GRAP2


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Basic Information Top
Gene Symbol:GRAP2 ( GADS,GRAP-2,GRB2L,GRBLG,GRID,GRPL,GrbX,Grf40,Mona,P38 )
Gene Full Name: GRB2-related adaptor protein 2
Band: 22q13.1
Quick LinksEntrez ID:9402; OMIM: 604518; Uniprot ID:GRAP2_HUMAN; ENSEMBL ID: ENSG00000100351; HGNC ID: 4563
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus16 / 56401228
neonate0 / 310970 
infant0 / 236200 
juvenile6 / 55556107
adult19 / 19391219
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia4 / 9584241
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal37 / 336030711
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood4 / 12347832
bone0 / 716550 
bone marrow2 / 4880140
brain2 / 11009891
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus1 / 2020949
eye0 / 2110540 
heart2 / 8962622
intestine2 / 2344728
kidney0 / 2117770 
larynx0 / 241450 
liver1 / 2077434
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta9 / 28082532
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen2 / 5395237
stomach0 / 966190 
testis0 / 3304420 
thymus112 / 811311380
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208406_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8
Adipocyte6.8
AdrenalCortex7.4
Adrenalgland5.7
Amygdala6.7
Appendix7.25
AtrioventricularNode5.3
BDCA4+_DentriticCells7.3
Bonemarrow6.85
BronchialEpithelialCells6.2
CD105+_Endothelial6.55
CD14+_Monocytes7.15
CD19+_BCells(neg._sel.)7.2
CD33+_Myeloid8.35
CD34+7.7
CD4+_Tcells45.7
CD56+_NKCells15.6
CD71+_EarlyErythroid13.55
CD8+_Tcells54.5
CardiacMyocytes9.5
Caudatenucleus6.05
Cerebellum5.4
CerebellumPeduncles7.7
CiliaryGanglion4.85
CingulateCortex7.9
Colorectaladenocarcinoma6.75
DorsalRootGanglion5.25
FetalThyroid6.45
Fetalbrain6.7
Fetalliver5.75
Fetallung5.45
GlobusPallidus5
Heart9.7
Hypothalamus6.45
Kidney5.55
Leukemia_chronicMyelogenousK-5626.1
Leukemia_promyelocytic-HL-605.8
Leukemialymphoblastic(MOLT-4)9.35
Liver8.9
Lung7.05
Lymphnode5.8
Lymphoma_burkitts(Daudi)8.65
Lymphoma_burkitts(Raji)9.45
MedullaOblongata6.1
OccipitalLobe6
OlfactoryBulb5.3
Ovary4.5
Pancreas5.45
PancreaticIslet7.2
ParietalLobe7.1
Pituitary7.8
Placenta6.6
Pons6.75
PrefrontalCortex8.15
Prostate7.8
Salivarygland5.4
SkeletalMuscle8.45
Skin5.25
SmoothMuscle7.4
Spinalcord7.2
SubthalamicNucleus6.2
SuperiorCervicalGanglion7.75
TemporalLobe6.2
Testis5.7
TestisGermCell5.55
TestisIntersitial5.6
TestisLeydigCell6.65
TestisSeminiferousTubule5.8
Thalamus6.85
Thymus26.75
Thyroid7.95
Tongue6.95
Tonsil6.55
Trachea5.6
TrigeminalGanglion6.8
Uterus5.5
UterusCorpus6.5
WholeBlood22.4
Wholebrain5.6
colon6.75
pineal_day8.26
pineal_night7.76
retina7.825
small_intestine6.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P143720
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.33 ± 0.96
Basal Forebrain2.14 ± 0.44
Basal Part of Pons1.58 ± 0.33
Cerebellar Cortex1.77 ± 0.62
Cerebellar Nuclei2.26 ± 0.7
Claustrum2.87 ± 0.86
Epithalamus1.9 ± 1
Frontal Lobe1.75 ± 0.59
Globus Pallidus2.51 ± 0.26
Hypothalamus1.99 ± 0.57
Insula1.86 ± 0.64
Limbic Lobe1.93 ± 0.6
Mesencephalon2.12 ± 0.66
Myelencephalon1.97 ± 0.66
Occipital Lobe1.97 ± 0.56
Parietal Lobe1.98 ± 0.64
Pontine Tegmentum1.99 ± 0.66
Striatum2.2 ± 0.67
Subthalamus2.18 ± 0.72
Temporal Lobe1.83 ± 0.66
Thalamus1.89 ± 0.55
White Matter2.39 ± 0.23
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Grap2CBCerebellum3.41
4.18
Grap2CTXCerebral cortex2.73
2.43
Grap2HIPHippocampal region3.82
3.4
Grap2HPFHippocampal formation3.49
2.99
Grap2HYHypothalamus6.6
8.29
Grap2LSXLateral septal complex1.52
1.54
Grap2MBMidbrain1.82
2.67
Grap2MYMedulla4.32
7.05
Grap2OLFOlfactory bulb7.96
7.5
Grap2PPons4.94
8.51
Grap2PALPallidum1.09
1.65
Grap2RHPRetrohippocampal region2.64
2.26
Grap2sAMYStriatum-like amygdalar nuclei0.92
0.65
Grap2STRStriatum1.34
1.38
Grap2STRdStriatum dorsal region0.53
0.41
Grap2STRvStriatum ventral region4.53
5.03
Grap2THThalamus2.08
1.67
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00487000 14 317 330 LGLFPANYVAPMTR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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