AutismKB 2.0

Annotation Detail for MED21


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Basic Information Top
Gene Symbol:MED21 ( SRB7,SURB7 )
Gene Full Name: mediator complex subunit 21
Band: 12p12
Quick LinksEntrez ID:9412; OMIM: 603800; Uniprot ID:MED21_HUMAN; ENSEMBL ID: ENSG00000152944; HGNC ID: 11473
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus26 / 56401246
neonate1 / 3109732
infant7 / 23620296
juvenile1 / 5555617
adult88 / 193912145
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma3 / 17475171
breast (mammary gland) tumor9 / 9417895
cervical tumor0 / 343660 
chondrosarcoma9 / 82823108
colorectal tumor5 / 11424643
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor27 / 263845102
glioma5 / 10688346
head and neck tumor6 / 13630244
kidney tumor3 / 6895943
leukemia2 / 9584220
liver tumor1 / 9635910
lung tumor2 / 10312719
lymphoma5 / 7175569
non-neoplasia3 / 9725030
normal153 / 336030745
ovarian tumor4 / 7668252
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer5 / 10268048
retinoblastoma2 / 4635643
skin tumor2 / 12494916
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites1 / 4001524
bladder6 / 29757201
blood12 / 12347897
bone5 / 7165569
bone marrow2 / 4880140
brain54 / 110098949
cervix0 / 481710 
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus2 / 2020998
eye5 / 21105423
heart3 / 8962633
intestine8 / 23447234
kidney13 / 21177761
larynx2 / 2414582
liver2 / 2077439
lung6 / 33697417
lymph0 / 442700 
lymph node0 / 916100 
mammary gland16 / 153271104
mouth3 / 6705244
muscle3 / 10771527
nerve1 / 1576863
ovary6 / 10205158
pancreas0 / 2148120 
parathyroid2 / 2053997
pharynx9 / 41328217
pituitary gland1 / 1658560
placenta4 / 28082514
prostate12 / 18934563
salivary gland0 / 201550 
skin5 / 21057423
spleen1 / 5395218
stomach1 / 9661910
testis38 / 330442114
thymus5 / 8113161
thyroid1 / 4747321
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus8 / 23287834
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209363_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts15.75
Adipocyte11.5
AdrenalCortex11.8
Adrenalgland11.2
Amygdala11.35
Appendix11.3
AtrioventricularNode8.9
BDCA4+_DentriticCells11.3
Bonemarrow11.05
BronchialEpithelialCells25.1
CD105+_Endothelial10.25
CD14+_Monocytes10.7
CD19+_BCells(neg._sel.)9.3
CD33+_Myeloid13.6
CD34+14.45
CD4+_Tcells11.05
CD56+_NKCells12.8
CD71+_EarlyErythroid10.25
CD8+_Tcells9.85
CardiacMyocytes14.85
Caudatenucleus9.9
Cerebellum9.4
CerebellumPeduncles12.5
CiliaryGanglion8.15
CingulateCortex11.2
Colorectaladenocarcinoma10.95
DorsalRootGanglion8.65
FetalThyroid10.45
Fetalbrain12.05
Fetalliver11.9
Fetallung13.15
GlobusPallidus7.55
Heart14.35
Hypothalamus11.75
Kidney9.5
Leukemia_chronicMyelogenousK-5629.9
Leukemia_promyelocytic-HL-609.7
Leukemialymphoblastic(MOLT-4)8.8
Liver14.65
Lung11.75
Lymphnode9.1
Lymphoma_burkitts(Daudi)14.1
Lymphoma_burkitts(Raji)15.45
MedullaOblongata9.9
OccipitalLobe9.2
OlfactoryBulb8.45
Ovary7.1
Pancreas8.2
PancreaticIslet12.4
ParietalLobe11.65
Pituitary19.35
Placenta11.15
Pons10.35
PrefrontalCortex12
Prostate10.7
Salivarygland8.85
SkeletalMuscle13.35
Skin8.6
SmoothMuscle20.7
Spinalcord11.5
SubthalamicNucleus10.05
SuperiorCervicalGanglion13.3
TemporalLobe9.95
Testis22
TestisGermCell17.55
TestisIntersitial34.25
TestisLeydigCell31.3
TestisSeminiferousTubule24.6
Thalamus11.1
Thymus8.5
Thyroid13.25
Tongue10.9
Tonsil10.65
Trachea9.45
TrigeminalGanglion11.45
Uterus9
UterusCorpus13.3
WholeBlood11.95
Wholebrain9.1
colon15.35
pineal_day13.54
pineal_night13.5
retina12.6
small_intestine10.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1193_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.29 ± 0.41
Basal Forebrain6.04 ± 0.21
Basal Part of Pons6.25 ± 0.34
Cerebellar Cortex6.4 ± 0.28
Cerebellar Nuclei6.17 ± 0.16
Claustrum6.4 ± 0.37
Epithalamus6.17 ± 0.5
Frontal Lobe6.2 ± 0.32
Globus Pallidus6.03 ± 0.23
Hypothalamus6.39 ± 0.33
Insula6.14 ± 0.2
Limbic Lobe6.27 ± 0.32
Mesencephalon6.21 ± 0.32
Myelencephalon6.22 ± 0.32
Occipital Lobe6.44 ± 0.31
Parietal Lobe6.37 ± 0.25
Pontine Tegmentum6.26 ± 0.3
Striatum6.23 ± 0.28
Subthalamus6.09 ± 0.23
Temporal Lobe6.18 ± 0.3
Thalamus6.23 ± 0.31
White Matter6.42 ± 0.16
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Surb7CBCerebellum9.4
10.4
Surb7CTXCerebral cortex6.49
5.66
Surb7HIPHippocampal region8.1
7.58
Surb7HPFHippocampal formation7.07
6.12
Surb7HYHypothalamus2.07
1.98
Surb7LSXLateral septal complex1.83
1.16
Surb7MBMidbrain3.62
3.93
Surb7MYMedulla4.9
6.71
Surb7OLFOlfactory bulb4.97
4.54
Surb7PPons4.52
6.27
Surb7PALPallidum2.04
1.91
Surb7RHPRetrohippocampal region5.42
4.09
Surb7sAMYStriatum-like amygdalar nuclei1.49
1.64
Surb7STRStriatum1.81
1.57
Surb7STRdStriatum dorsal region2.01
1.82
Surb7STRvStriatum ventral region1.4
0.85
Surb7THThalamus3.19
2.57
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00010713 18 93 110 LEEENHEAATCLEDVVYR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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