AutismKB 2.0

Annotation Detail for TJP2


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Basic Information Top
Gene Symbol:TJP2 ( MGC26306,X104,ZO2 )
Gene Full Name: tight junction protein 2 (zona occludens 2)
Band: 9q21.11
Quick LinksEntrez ID:9414; OMIM: 607709; Uniprot ID:ZO2_HUMAN; ENSEMBL ID: ENSG00000119139; HGNC ID: 11828
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body13 / 70761183
blastocyst3 / 6231948
fetus33 / 56401258
neonate2 / 3109764
infant0 / 236200 
juvenile8 / 55556143
adult178 / 193912191
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor8 / 9417884
cervical tumor4 / 34366116
chondrosarcoma8 / 8282396
colorectal tumor32 / 114246280
esophageal tumor0 / 172900 
gastrointestinal tumor11 / 11936992
germ cell tumor9 / 26384534
glioma5 / 10688346
head and neck tumor23 / 136302168
kidney tumor7 / 68959101
leukemia4 / 9584241
liver tumor15 / 96359155
lung tumor4 / 10312738
lymphoma7 / 7175597
non-neoplasia10 / 97250102
normal325 / 336030796
ovarian tumor3 / 7668239
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer8 / 10268077
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor10 / 90257110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder1 / 2975733
blood4 / 12347832
bone6 / 7165583
bone marrow0 / 488010 
brain158 / 1100989143
cervix6 / 48171124
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue23 / 215722106
esophagus0 / 202090 
eye20 / 21105494
heart3 / 8962633
intestine44 / 234472187
kidney18 / 21177784
larynx4 / 24145165
liver29 / 207743139
lung28 / 33697483
lymph0 / 442700 
lymph node5 / 9161054
mammary gland15 / 15327197
mouth8 / 67052119
muscle1 / 1077159
nerve1 / 1576863
ovary3 / 10205129
pancreas10 / 21481246
parathyroid7 / 20539340
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta11 / 28082539
prostate11 / 18934558
salivary gland0 / 201550 
skin2 / 2105749
spleen2 / 5395237
stomach9 / 9661993
testis38 / 330442114
thymus8 / 8113198
thyroid15 / 47473315
tonsil0 / 169990 
trachea9 / 52413171
umbilical cord1 / 1368073
uterus23 / 23287898
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202085_at
Cell line Expression level Expression bar
721_B_lymphoblasts212
Adipocyte29.85
AdrenalCortex6.7
Adrenalgland5.6
Amygdala194.3
Appendix7.1
AtrioventricularNode7.3
BDCA4+_DentriticCells19.05
Bonemarrow6
BronchialEpithelialCells149.4
CD105+_Endothelial59.55
CD14+_Monocytes14.3
CD19+_BCells(neg._sel.)6.15
CD33+_Myeloid11.6
CD34+29.4
CD4+_Tcells6
CD56+_NKCells7.65
CD71+_EarlyErythroid35.55
CD8+_Tcells5.2
CardiacMyocytes12.9
Caudatenucleus51.35
Cerebellum28.45
CerebellumPeduncles28.8
CiliaryGanglion8.7
CingulateCortex11
Colorectaladenocarcinoma213.65
DorsalRootGanglion7.85
FetalThyroid78.1
Fetalbrain5.95
Fetalliver28.55
Fetallung140.7
GlobusPallidus4.75
Heart8.85
Hypothalamus136.05
Kidney26.35
Leukemia_chronicMyelogenousK-56215.4
Leukemia_promyelocytic-HL-606.75
Leukemialymphoblastic(MOLT-4)4.85
Liver17
Lung85.35
Lymphnode6.05
Lymphoma_burkitts(Daudi)14.2
Lymphoma_burkitts(Raji)20
MedullaOblongata20.75
OccipitalLobe37.25
OlfactoryBulb155.95
Ovary4.3
Pancreas41.25
PancreaticIslet23.1
ParietalLobe27.05
Pituitary6.75
Placenta137.95
Pons7.65
PrefrontalCortex71.95
Prostate42.55
Salivarygland20.45
SkeletalMuscle7.9
Skin5.65
SmoothMuscle26.4
Spinalcord793.2
SubthalamicNucleus10.7
SuperiorCervicalGanglion7.85
TemporalLobe5.45
Testis84.6
TestisGermCell76.55
TestisIntersitial20.45
TestisLeydigCell18.55
TestisSeminiferousTubule28.8
Thalamus34.55
Thymus64.3
Thyroid261.45
Tongue8.95
Tonsil16.75
Trachea48.3
TrigeminalGanglion7.6
Uterus18.45
UterusCorpus5.5
WholeBlood8.8
Wholebrain65.3
colon134.55
pineal_day93.78
pineal_night27.96
retina319.025
small_intestine159.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P201153
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.73 ± 0.75
Basal Forebrain5.3 ± 0.74
Basal Part of Pons5.06 ± 0.5
Cerebellar Cortex5.23 ± 0.81
Cerebellar Nuclei5.58 ± 0.73
Claustrum4.39 ± 0.83
Epithalamus6.52 ± 0.68
Frontal Lobe4.91 ± 0.85
Globus Pallidus6.5 ± 0.7
Hypothalamus5.41 ± 1.16
Insula4.81 ± 0.55
Limbic Lobe4.86 ± 0.96
Mesencephalon5.09 ± 0.87
Myelencephalon5.21 ± 0.69
Occipital Lobe5.03 ± 0.56
Parietal Lobe4.71 ± 0.96
Pontine Tegmentum5.07 ± 0.57
Striatum5.2 ± 0.85
Subthalamus4.5 ± 0.64
Temporal Lobe4.79 ± 0.76
Thalamus5.24 ± 0.53
White Matter7.53 ± 0.48
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tjp2CBCerebellum17.72
36.32
Tjp2CTXCerebral cortex3.11
2.38
Tjp2HIPHippocampal region1.74
1.72
Tjp2HPFHippocampal formation1.57
1.42
Tjp2HYHypothalamus0.64
0.43
Tjp2LSXLateral septal complex0.34
0.36
Tjp2MBMidbrain2.14
1.98
Tjp2MYMedulla2.34
2.51
Tjp2OLFOlfactory bulb1.63
2.4
Tjp2PPons1.28
1.17
Tjp2PALPallidum1.51
1.07
Tjp2RHPRetrohippocampal region1.27
0.97
Tjp2sAMYStriatum-like amygdalar nuclei0.6
0.42
Tjp2STRStriatum2
1.38
Tjp2STRdStriatum dorsal region2.95
2.1
Tjp2STRvStriatum ventral region0.77
0.4
Tjp2THThalamus2.33
1.71
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00007154 17 611 627 SHFECEKETPQSLAFTR Peptide Atlas
ZO2_HUMAN_1168 9 1168 1176 QQLSEHSKR PRIDE
ZO2_HUMAN_139 11 139 149 AFEVMDEFDGR PRIDE
ZO2_HUMAN_301 12 301 312 GRPGPIGVLLMK PRIDE
ZO2_HUMAN_554 11 554 564 QILKVNTQDFR PRIDE
ZO2_HUMAN_564 27 564 590 GLVREDAVLYLLEIPKGEMVTILAQSR PRIDE
ZO2_HUMAN_665 12 665 676 AEQMASVQNAQR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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