AutismKB 2.0

Annotation Detail for TNFRSF8


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Basic Information Top
Gene Symbol:TNFRSF8 ( CD30,D1S166E,Ki-1 )
Gene Full Name: tumor necrosis factor receptor superfamily, member 8
Band: 1p36.22
Quick LinksEntrez ID:943; OMIM: 153243; Uniprot ID:TNR8_HUMAN; ENSEMBL ID: ENSG00000120949; HGNC ID: 11923
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst3 / 6231948
fetus0 / 5640120 
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult7 / 19391213
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor3 / 26384511
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal11 / 33603073
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone0 / 716550 
bone marrow0 / 488010 
brain0 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine1 / 2344724
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node1 / 9161010
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland1 / 2015549
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206729_at
Cell line Expression level Expression bar
721_B_lymphoblasts91.45
Adipocyte3.8
AdrenalCortex4.05
Adrenalgland3.3
Amygdala4.25
Appendix4
AtrioventricularNode3.05
BDCA4+_DentriticCells4.8
Bonemarrow3.95
BronchialEpithelialCells3.95
CD105+_Endothelial4.15
CD14+_Monocytes15.8
CD19+_BCells(neg._sel.)4.3
CD33+_Myeloid9.8
CD34+5.1
CD4+_Tcells4.45
CD56+_NKCells7.45
CD71+_EarlyErythroid3.75
CD8+_Tcells4
CardiacMyocytes5.8
Caudatenucleus3.4
Cerebellum3.25
CerebellumPeduncles4.5
CiliaryGanglion2.85
CingulateCortex4.05
Colorectaladenocarcinoma8.9
DorsalRootGanglion2.95
FetalThyroid3.9
Fetalbrain4.05
Fetalliver3.4
Fetallung3.05
GlobusPallidus2.9
Heart7.25
Hypothalamus4.2
Kidney3
Leukemia_chronicMyelogenousK-5628.2
Leukemia_promyelocytic-HL-603.5
Leukemialymphoblastic(MOLT-4)3.35
Liver5.2
Lung4.55
Lymphnode3.45
Lymphoma_burkitts(Daudi)5.1
Lymphoma_burkitts(Raji)6.7
MedullaOblongata3.65
OccipitalLobe3.35
OlfactoryBulb3.15
Ovary2.6
Pancreas3.15
PancreaticIslet4.25
ParietalLobe4.15
Pituitary4.65
Placenta4.2
Pons3.8
PrefrontalCortex5.05
Prostate4.9
Salivarygland3.2
SkeletalMuscle4.55
Skin3.05
SmoothMuscle4.55
Spinalcord4.25
SubthalamicNucleus3.6
SuperiorCervicalGanglion4.4
TemporalLobe3.65
Testis4
TestisGermCell3.4
TestisIntersitial4.85
TestisLeydigCell3.95
TestisSeminiferousTubule3.7
Thalamus4
Thymus3.15
Thyroid5.7
Tongue4.75
Tonsil3.9
Trachea3.35
TrigeminalGanglion3.7
Uterus3.55
UterusCorpus3.55
WholeBlood6.2
Wholebrain3.45
colon4.05
pineal_day5.02
pineal_night4.92
retina4.85
small_intestine3.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14395_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.95 ± 1.1
Basal Forebrain1.28 ± 0.23
Basal Part of Pons1.12 ± 0.6
Cerebellar Cortex1.28 ± 0.69
Cerebellar Nuclei1.84 ± 0.85
Claustrum2.32 ± 0.96
Epithalamus1.2 ± 0.7
Frontal Lobe1.29 ± 0.77
Globus Pallidus1.96 ± 0.46
Hypothalamus1.49 ± 0.75
Insula1.16 ± 0.46
Limbic Lobe1.47 ± 0.76
Mesencephalon1.56 ± 0.85
Myelencephalon1.47 ± 0.78
Occipital Lobe1.54 ± 0.9
Parietal Lobe1.42 ± 0.87
Pontine Tegmentum1.55 ± 0.79
Striatum1.67 ± 0.86
Subthalamus1.39 ± 0.69
Temporal Lobe1.45 ± 0.87
Thalamus1.39 ± 0.69
White Matter1.81 ± 0.45
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tnfrsf8CBCerebellum0.32
0.69
Tnfrsf8CTXCerebral cortex0.82
1.19
Tnfrsf8HIPHippocampal region0.13
0.28
Tnfrsf8HPFHippocampal formation0.1
0.18
Tnfrsf8HYHypothalamus0.29
0.31
Tnfrsf8LSXLateral septal complex0.05
0
Tnfrsf8MBMidbrain0.06
0.09
Tnfrsf8MYMedulla0.15
0.17
Tnfrsf8OLFOlfactory bulb1.34
1.84
Tnfrsf8PPons0.09
0.2
Tnfrsf8PALPallidum0.26
0.37
Tnfrsf8RHPRetrohippocampal region0.06
0.06
Tnfrsf8sAMYStriatum-like amygdalar nuclei0.08
0.83
Tnfrsf8STRStriatum0.23
0.45
Tnfrsf8STRdStriatum dorsal region0.3
0.54
Tnfrsf8STRvStriatum ventral region0.17
0.17
Tnfrsf8THThalamus0.08
0.13
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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