AutismKB 2.0

Annotation Detail for MED23


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Basic Information Top
Gene Symbol:MED23 ( ARC130,CRSP130,CRSP133,CRSP3,DKFZp434H0117,DRIP130,SUR-2,SUR2 )
Gene Full Name: mediator complex subunit 23
Band: 6q23.2
Quick LinksEntrez ID:9439; OMIM: 605042; Uniprot ID:MED23_HUMAN; ENSEMBL ID: ENSG00000112282; HGNC ID: 2372
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst4 / 6231964
fetus17 / 56401230
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult73 / 193912137
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor4 / 26384515
glioma0 / 1068830 
head and neck tumor12 / 13630288
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal116 / 336030734
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites1 / 4001524
bladder1 / 2975733
blood1 / 1234788
bone4 / 7165555
bone marrow0 / 488010 
brain27 / 110098924
cervix0 / 481710 
connective tissue1 / 1492556
ear1 / 1621261
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye3 / 21105414
heart1 / 8962611
intestine7 / 23447229
kidney4 / 21177718
larynx8 / 24145331
liver8 / 20774338
lung9 / 33697426
lymph0 / 442700 
lymph node8 / 9161087
mammary gland4 / 15327126
mouth4 / 6705259
muscle11 / 107715102
nerve3 / 15768190
ovary2 / 10205119
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta11 / 28082539
prostate2 / 18934510
salivary gland2 / 2015599
skin3 / 21057414
spleen0 / 539520 
stomach6 / 9661962
testis13 / 33044239
thymus4 / 8113149
thyroid1 / 4747321
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord0 / 136800 
uterus12 / 23287851
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218846_at
Cell line Expression level Expression bar
721_B_lymphoblasts31.35
Adipocyte18.8
AdrenalCortex16.9
Adrenalgland18
Amygdala23.15
Appendix21.5
AtrioventricularNode12.9
BDCA4+_DentriticCells32.6
Bonemarrow22.7
BronchialEpithelialCells18.8
CD105+_Endothelial19.6
CD14+_Monocytes21.35
CD19+_BCells(neg._sel.)30.7
CD33+_Myeloid24.4
CD34+35.2
CD4+_Tcells90.8
CD56+_NKCells47.6
CD71+_EarlyErythroid18.6
CD8+_Tcells95.2
CardiacMyocytes25.65
Caudatenucleus17.8
Cerebellum12.65
CerebellumPeduncles23.8
CiliaryGanglion14.05
CingulateCortex21.25
Colorectaladenocarcinoma19.1
DorsalRootGanglion15.15
FetalThyroid20.25
Fetalbrain35.75
Fetalliver18.4
Fetallung23.1
GlobusPallidus12.3
Heart19.45
Hypothalamus23.25
Kidney12.45
Leukemia_chronicMyelogenousK-56218.2
Leukemia_promyelocytic-HL-6018.35
Leukemialymphoblastic(MOLT-4)19.35
Liver23.35
Lung11.45
Lymphnode34.1
Lymphoma_burkitts(Daudi)27.3
Lymphoma_burkitts(Raji)35.65
MedullaOblongata18.05
OccipitalLobe17.7
OlfactoryBulb14.55
Ovary16
Pancreas16.35
PancreaticIslet21.3
ParietalLobe21.95
Pituitary23.5
Placenta18.4
Pons20.05
PrefrontalCortex30.95
Prostate30.75
Salivarygland21
SkeletalMuscle19.45
Skin10.15
SmoothMuscle22.3
Spinalcord27.2
SubthalamicNucleus17
SuperiorCervicalGanglion24.9
TemporalLobe18.65
Testis15.15
TestisGermCell16.25
TestisIntersitial15.45
TestisLeydigCell21
TestisSeminiferousTubule16.65
Thalamus16.25
Thymus18.6
Thyroid48.95
Tongue19.4
Tonsil20.3
Trachea21.25
TrigeminalGanglion17.1
Uterus63.25
UterusCorpus17.55
WholeBlood78
Wholebrain12.6
colon26.8
pineal_day33.06
pineal_night30.34
retina24.25
small_intestine18.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P145501
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.4 ± 0.49
Basal Forebrain5.33 ± 0.27
Basal Part of Pons5.27 ± 0.25
Cerebellar Cortex5.54 ± 0.26
Cerebellar Nuclei5 ± 0.39
Claustrum5.27 ± 0.68
Epithalamus4.91 ± 0.41
Frontal Lobe5.04 ± 0.4
Globus Pallidus5.05 ± 0.46
Hypothalamus5.21 ± 0.4
Insula4.92 ± 0.3
Limbic Lobe5.23 ± 0.45
Mesencephalon5.13 ± 0.44
Myelencephalon5.2 ± 0.43
Occipital Lobe5.55 ± 0.34
Parietal Lobe5.31 ± 0.4
Pontine Tegmentum5.2 ± 0.48
Striatum4.98 ± 0.39
Subthalamus5.25 ± 0.34
Temporal Lobe5.26 ± 0.36
Thalamus5.2 ± 0.4
White Matter5.85 ± 0.21
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Crsp3CBCerebellum29.86
53.16
Crsp3CTXCerebral cortex63.92
59.47
Crsp3HIPHippocampal region45.04
57.55
Crsp3HPFHippocampal formation55.61
58.23
Crsp3HYHypothalamus52.05
43.88
Crsp3LSXLateral septal complex55.72
51.83
Crsp3MBMidbrain48.89
46.71
Crsp3MYMedulla45.52
56.17
Crsp3OLFOlfactory bulb70.37
66.28
Crsp3PPons38.67
40.33
Crsp3PALPallidum51.53
47.42
Crsp3RHPRetrohippocampal region63.88
59.77
Crsp3sAMYStriatum-like amygdalar nuclei55.13
48.9
Crsp3STRStriatum56.31
48.73
Crsp3STRdStriatum dorsal region56.17
47.75
Crsp3STRvStriatum ventral region57.94
51.72
Crsp3THThalamus55.04
53.69
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00010498 30 513 542 IPLPGTNCMASGSITPLPMNLLDSLTVHAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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