AutismKB 2.0

Annotation Detail for SH3BP5


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Basic Information Top
Gene Symbol:SH3BP5 ( SAB )
Gene Full Name: SH3-domain binding protein 5 (BTK-associated)
Band: 3p25.1
Quick LinksEntrez ID:9467; OMIM: 605612; Uniprot ID:3BP5_HUMAN; ENSEMBL ID: ENSG00000131370; HGNC ID: 10827
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus19 / 56401233
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult80 / 193912141
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor6 / 34366174
chondrosarcoma8 / 8282396
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor21 / 26384579
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia5 / 9584252
liver tumor2 / 9635920
lung tumor5 / 10312748
lymphoma1 / 7175513
non-neoplasia7 / 9725071
normal112 / 336030733
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer4 / 10268038
retinoblastoma3 / 4635664
skin tumor22 / 124949176
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland7 / 33197210
ascites0 / 400150 
bladder0 / 297570 
blood6 / 12347848
bone6 / 7165583
bone marrow2 / 4880140
brain46 / 110098941
cervix6 / 48171124
connective tissue6 / 14925540
ear1 / 1621261
embryonic tissue4 / 21572218
esophagus1 / 2020949
eye10 / 21105447
heart1 / 8962611
intestine2 / 2344728
kidney1 / 2117774
larynx0 / 241450 
liver3 / 20774314
lung30 / 33697489
lymph1 / 4427022
lymph node5 / 9161054
mammary gland6 / 15327139
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas5 / 21481223
parathyroid8 / 20539389
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta24 / 28082585
prostate7 / 18934536
salivary gland2 / 2015599
skin22 / 210574104
spleen1 / 5395218
stomach1 / 9661910
testis8 / 33044224
thymus1 / 8113112
thyroid0 / 474730 
tonsil2 / 16999117
trachea1 / 5241319
umbilical cord1 / 1368073
uterus5 / 23287821
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201811_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts17.5
Adipocyte193.55
AdrenalCortex2584.55
Adrenalgland1542.7
Amygdala410.3
Appendix145.3
AtrioventricularNode169.35
BDCA4+_DentriticCells468.95
Bonemarrow97.15
BronchialEpithelialCells21.05
CD105+_Endothelial42.1
CD14+_Monocytes250.85
CD19+_BCells(neg._sel.)1375.1
CD33+_Myeloid524.75
CD34+41.3
CD4+_Tcells454.95
CD56+_NKCells1937.1
CD71+_EarlyErythroid15.1
CD8+_Tcells344.1
CardiacMyocytes54.4
Caudatenucleus206.95
Cerebellum279.9
CerebellumPeduncles559.1
CiliaryGanglion204.25
CingulateCortex221
Colorectaladenocarcinoma44.85
DorsalRootGanglion159.7
FetalThyroid148
Fetalbrain830.5
Fetalliver40.7
Fetallung345.5
GlobusPallidus132.55
Heart40.95
Hypothalamus372.95
Kidney63
Leukemia_chronicMyelogenousK-56237.85
Leukemia_promyelocytic-HL-6032.8
Leukemialymphoblastic(MOLT-4)49.75
Liver58.55
Lung690.8
Lymphnode389.4
Lymphoma_burkitts(Daudi)58.6
Lymphoma_burkitts(Raji)36.1
MedullaOblongata137.55
OccipitalLobe266.55
OlfactoryBulb487.15
Ovary770.45
Pancreas27.6
PancreaticIslet79.05
ParietalLobe127.2
Pituitary287.45
Placenta539.55
Pons50.2
PrefrontalCortex531.85
Prostate100.85
Salivarygland336.45
SkeletalMuscle49.5
Skin45.55
SmoothMuscle114.75
Spinalcord317.85
SubthalamicNucleus147.8
SuperiorCervicalGanglion133
TemporalLobe79.05
Testis170.5
TestisGermCell334.15
TestisIntersitial91.8
TestisLeydigCell67.75
TestisSeminiferousTubule109.85
Thalamus200.4
Thymus182.35
Thyroid421.6
Tongue43
Tonsil202.05
Trachea143.25
TrigeminalGanglion129.1
Uterus505.2
UterusCorpus172.5
WholeBlood401.5
Wholebrain296.45
colon74.15
pineal_day433.54
pineal_night533.76
retina541.05
small_intestine172.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P148750
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.43 ± 0.46
Basal Forebrain6.19 ± 0.26
Basal Part of Pons6.51 ± 0.53
Cerebellar Cortex6.8 ± 0.34
Cerebellar Nuclei6.38 ± 0.45
Claustrum5.93 ± 0.55
Epithalamus6.01 ± 0.47
Frontal Lobe6.55 ± 0.44
Globus Pallidus6.09 ± 0.28
Hypothalamus6.16 ± 0.26
Insula6.42 ± 0.33
Limbic Lobe6.5 ± 0.51
Mesencephalon6.21 ± 0.57
Myelencephalon6.34 ± 0.55
Occipital Lobe5.81 ± 0.56
Parietal Lobe6.26 ± 0.41
Pontine Tegmentum6.36 ± 0.37
Striatum5.86 ± 0.32
Subthalamus6.36 ± 0.22
Temporal Lobe6.49 ± 0.4
Thalamus6.08 ± 0.52
White Matter7.51 ± 0.1
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Sh3bp5CBCerebellum20.8
26
Sh3bp5CTXCerebral cortex8.52
8.15
Sh3bp5HIPHippocampal region55.88
100
Sh3bp5HPFHippocampal formation41.8
70.63
Sh3bp5HYHypothalamus3.73
3.45
Sh3bp5LSXLateral septal complex3.74
3.9
Sh3bp5MBMidbrain2.66
3.65
Sh3bp5MYMedulla7.37
8.91
Sh3bp5OLFOlfactory bulb22.74
20.14
Sh3bp5PPons5.79
7.21
Sh3bp5PALPallidum3.8
4.31
Sh3bp5RHPRetrohippocampal region12.92
12.58
Sh3bp5sAMYStriatum-like amygdalar nuclei4.38
5.12
Sh3bp5STRStriatum4.16
4.45
Sh3bp5STRdStriatum dorsal region2.67
3.29
Sh3bp5STRvStriatum ventral region8.22
6.9
Sh3bp5THThalamus2.87
3.79
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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