AutismKB 2.0

Annotation Detail for AKAP6


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Basic Information Top
Gene Symbol:AKAP6 ( ADAP100,ADAP6,AKAP100,KIAA0311,MGC165020,PRKA6,mAKAP )
Gene Full Name: A kinase (PRKA) anchor protein 6
Band: 14q12
Quick LinksEntrez ID:9472; OMIM: 604691; Uniprot ID:AKAP6_HUMAN; ENSEMBL ID: ENSG00000151320; HGNC ID: 376
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus13 / 56401223
neonate0 / 310970 
infant0 / 236200 
juvenile5 / 5555689
adult60 / 193912130
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor6 / 26384522
glioma1 / 1068839
head and neck tumor3 / 13630222
kidney tumor2 / 6895929
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia11 / 97250113
normal98 / 336030729
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain83 / 110098975
cervix0 / 481710 
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye5 / 21105423
heart2 / 8962622
intestine2 / 2344728
kidney2 / 2117779
larynx0 / 241450 
liver1 / 2077434
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle6 / 10771555
nerve3 / 15768190
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta5 / 28082517
prostate3 / 18934515
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach0 / 966190 
testis13 / 33044239
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217669_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.65
Adipocyte5.65
AdrenalCortex7.15
Adrenalgland5.1
Amygdala5.85
Appendix6.5
AtrioventricularNode5.1
BDCA4+_DentriticCells5.8
Bonemarrow6.15
BronchialEpithelialCells5.6
CD105+_Endothelial5.65
CD14+_Monocytes6.1
CD19+_BCells(neg._sel.)5.95
CD33+_Myeloid7.1
CD34+6.9
CD4+_Tcells5.95
CD56+_NKCells6.5
CD71+_EarlyErythroid5.5
CD8+_Tcells5.25
CardiacMyocytes8.6
Caudatenucleus5.15
Cerebellum4.8
CerebellumPeduncles7.1
CiliaryGanglion4.65
CingulateCortex6.1
Colorectaladenocarcinoma5.8
DorsalRootGanglion4.9
FetalThyroid5.7
Fetalbrain5.5
Fetalliver5.15
Fetallung4.5
GlobusPallidus4.5
Heart8.45
Hypothalamus6
Kidney5.05
Leukemia_chronicMyelogenousK-5625.25
Leukemia_promyelocytic-HL-605.1
Leukemialymphoblastic(MOLT-4)4.6
Liver8.4
Lung6.25
Lymphnode4.8
Lymphoma_burkitts(Daudi)7.65
Lymphoma_burkitts(Raji)8.75
MedullaOblongata5.25
OccipitalLobe5.15
OlfactoryBulb4.5
Ovary4.25
Pancreas4.8
PancreaticIslet6.25
ParietalLobe6.45
Pituitary6.75
Placenta5.7
Pons5.7
PrefrontalCortex6.95
Prostate6.55
Salivarygland4.85
SkeletalMuscle9.35
Skin4.9
SmoothMuscle6.5
Spinalcord6.1
SubthalamicNucleus5.45
SuperiorCervicalGanglion7.75
TemporalLobe5.45
Testis4.95
TestisGermCell5.2
TestisIntersitial4.95
TestisLeydigCell7.4
TestisSeminiferousTubule4.95
Thalamus6
Thymus4.4
Thyroid7
Tongue6.3
Tonsil5.75
Trachea4.85
TrigeminalGanglion6.65
Uterus4.6
UterusCorpus5.55
WholeBlood6.35
Wholebrain4.6
colon5.8
pineal_day7.04
pineal_night6.96
retina6.975
small_intestine5.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P14351
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.6 ± 0.55
Basal Forebrain4.21 ± 0.55
Basal Part of Pons5.02 ± 0.26
Cerebellar Cortex4.35 ± 0.46
Cerebellar Nuclei4.32 ± 0.64
Claustrum4.96 ± 0.46
Epithalamus4.03 ± 0.51
Frontal Lobe4.61 ± 0.56
Globus Pallidus3.76 ± 0.67
Hypothalamus4.81 ± 0.43
Insula4.44 ± 0.26
Limbic Lobe4.41 ± 0.49
Mesencephalon4.7 ± 0.6
Myelencephalon4.47 ± 0.59
Occipital Lobe4.77 ± 0.38
Parietal Lobe4.68 ± 0.57
Pontine Tegmentum4.37 ± 0.59
Striatum3.94 ± 0.62
Subthalamus4.92 ± 0.3
Temporal Lobe4.49 ± 0.47
Thalamus4.61 ± 0.51
White Matter3.48 ± 0.61
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Akap6CBCerebellum28.67
71.01
Akap6CTXCerebral cortex100
100
Akap6HIPHippocampal region49.38
82.28
Akap6HPFHippocampal formation60.39
79.67
Akap6HYHypothalamus38.85
37.87
Akap6LSXLateral septal complex39.13
36.97
Akap6MBMidbrain42.64
46.83
Akap6MYMedulla59.39
80.2
Akap6OLFOlfactory bulb79.9
82.69
Akap6PPons42.57
56.69
Akap6PALPallidum40.56
44.1
Akap6RHPRetrohippocampal region85.05
81.68
Akap6sAMYStriatum-like amygdalar nuclei48.07
40.7
Akap6STRStriatum72.22
58.71
Akap6STRdStriatum dorsal region81.33
66.3
Akap6STRvStriatum ventral region58.17
46.09
Akap6THThalamus68.91
76.17
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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