AutismKB 2.0

Annotation Detail for SLC4A8


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Basic Information Top
Gene Symbol:SLC4A8 ( DKFZp761B2318,FLJ46462,NBC3,NDCBE )
Gene Full Name: solute carrier family 4, sodium bicarbonate cotransporter, member 8
Band: 12q13.13
Quick LinksEntrez ID:9498; OMIM: 605024; Uniprot ID:S4A8_HUMAN; ENSEMBL ID: ENSG00000050438; HGNC ID: 11034
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst1 / 6231916
fetus16 / 56401228
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult49 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor27 / 94178286
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma7 / 10688365
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal77 / 336030722
ovarian tumor7 / 7668291
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone1 / 7165513
bone marrow2 / 4880140
brain38 / 110098934
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine1 / 2344724
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node1 / 9161010
mammary gland29 / 153271189
mouth0 / 670520 
muscle2 / 10771518
nerve2 / 15768126
ovary7 / 10205168
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen2 / 5395237
stomach0 / 966190 
testis30 / 33044290
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207056_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.25
Adipocyte7.35
AdrenalCortex8.85
Adrenalgland6.75
Amygdala8.6
Appendix8.35
AtrioventricularNode11.65
BDCA4+_DentriticCells7.85
Bonemarrow7.8
BronchialEpithelialCells7.4
CD105+_Endothelial7.4
CD14+_Monocytes8.3
CD19+_BCells(neg._sel.)7.65
CD33+_Myeloid13.9
CD34+10
CD4+_Tcells8.15
CD56+_NKCells8.85
CD71+_EarlyErythroid8.35
CD8+_Tcells7
CardiacMyocytes14.5
Caudatenucleus6.95
Cerebellum6.3
CerebellumPeduncles9.15
CiliaryGanglion6.4
CingulateCortex8.8
Colorectaladenocarcinoma7.65
DorsalRootGanglion7.95
FetalThyroid7.6
Fetalbrain7.45
Fetalliver6.7
Fetallung5.7
GlobusPallidus6.5
Heart11.6
Hypothalamus7.8
Kidney9.35
Leukemia_chronicMyelogenousK-5626.95
Leukemia_promyelocytic-HL-606.7
Leukemialymphoblastic(MOLT-4)6.05
Liver11.05
Lung8.35
Lymphnode6.15
Lymphoma_burkitts(Daudi)10.3
Lymphoma_burkitts(Raji)11.85
MedullaOblongata7.35
OccipitalLobe8.4
OlfactoryBulb5.8
Ovary5.95
Pancreas9.1
PancreaticIslet8.25
ParietalLobe9.45
Pituitary10.8
Placenta7.35
Pons11.65
PrefrontalCortex22.6
Prostate9
Salivarygland6.4
SkeletalMuscle11.1
Skin6.85
SmoothMuscle8.6
Spinalcord8.25
SubthalamicNucleus8.15
SuperiorCervicalGanglion16.35
TemporalLobe7.3
Testis7.9
TestisGermCell15.4
TestisIntersitial10.55
TestisLeydigCell9.85
TestisSeminiferousTubule19.5
Thalamus13.4
Thymus5.65
Thyroid8.85
Tongue8.15
Tonsil7.95
Trachea6.45
TrigeminalGanglion11.5
Uterus5.95
UterusCorpus7.15
WholeBlood8.15
Wholebrain6.1
colon7.55
pineal_day13.3
pineal_night15.32
retina10.1
small_intestine7.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P72912
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.35 ± 0.44
Basal Forebrain4.2 ± 0.31
Basal Part of Pons4.78 ± 0.42
Cerebellar Cortex4.66 ± 0.27
Cerebellar Nuclei4.47 ± 0.38
Claustrum4.25 ± 0.63
Epithalamus4.26 ± 0.55
Frontal Lobe4.47 ± 0.43
Globus Pallidus4.27 ± 0.36
Hypothalamus3.81 ± 0.44
Insula4.35 ± 0.28
Limbic Lobe4.49 ± 0.49
Mesencephalon4.44 ± 0.49
Myelencephalon4.45 ± 0.53
Occipital Lobe4.72 ± 0.36
Parietal Lobe4.64 ± 0.4
Pontine Tegmentum4.27 ± 0.45
Striatum3.75 ± 0.48
Subthalamus4.95 ± 0.56
Temporal Lobe4.4 ± 0.4
Thalamus4.47 ± 0.4
White Matter5.47 ± 0.11
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Slc4a8CBCerebellum3.8
3.25
Slc4a8CTXCerebral cortex0.5
0.42
Slc4a8HIPHippocampal region5.38
2.81
Slc4a8HPFHippocampal formation3.78
1.89
Slc4a8HYHypothalamus0.71
0.4
Slc4a8LSXLateral septal complex0.02
0
Slc4a8MBMidbrain1.65
1.21
Slc4a8MYMedulla9.25
6.82
Slc4a8OLFOlfactory bulb1.56
1.74
Slc4a8PPons4.16
2.75
Slc4a8PALPallidum0.39
0.26
Slc4a8RHPRetrohippocampal region0.72
0.46
Slc4a8sAMYStriatum-like amygdalar nuclei0.32
0.24
Slc4a8STRStriatum0.12
0.1
Slc4a8STRdStriatum dorsal region0.13
0.11
Slc4a8STRvStriatum ventral region0.05
0.02
Slc4a8THThalamus0.56
0.33
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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