AutismKB 2.0

Annotation Detail for SCARB2


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Basic Information Top
Gene Symbol:SCARB2 ( AMRF,CD36L2,HLGP85,LIMPII,SR-BII )
Gene Full Name: scavenger receptor class B, member 2
Band: 4q21.1
Quick LinksEntrez ID:950; OMIM: 602257; Uniprot ID:SCRB2_HUMAN; ENSEMBL ID: ENSG00000138760; HGNC ID: 1665
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst4 / 6231964
fetus90 / 564012159
neonate4 / 31097128
infant0 / 236200 
juvenile9 / 55556161
adult260 / 1939121134
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma2 / 17475114
breast (mammary gland) tumor9 / 9417895
cervical tumor0 / 343660 
chondrosarcoma22 / 82823265
colorectal tumor10 / 11424687
esophageal tumor6 / 17290347
gastrointestinal tumor17 / 119369142
germ cell tumor27 / 263845102
glioma22 / 106883205
head and neck tumor5 / 13630236
kidney tumor7 / 68959101
leukemia2 / 9584220
liver tumor6 / 9635962
lung tumor4 / 10312738
lymphoma1 / 7175513
non-neoplasia17 / 97250174
normal456 / 3360307135
ovarian tumor5 / 7668265
pancreatic tumor20 / 104616191
primitive neuroectodermal tumor of the CNS13 / 125680103
prostate cancer10 / 10268097
retinoblastoma12 / 46356258
skin tumor13 / 124949104
soft tissue/muscle tissue tumor12 / 12519195
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland7 / 33197210
ascites6 / 40015149
bladder1 / 2975733
blood7 / 12347856
bone12 / 71655167
bone marrow1 / 4880120
brain148 / 1100989134
cervix0 / 481710 
connective tissue32 / 149255214
ear1 / 1621261
embryonic tissue18 / 21572283
esophagus6 / 20209296
eye46 / 211054217
heart14 / 89626156
intestine20 / 23447285
kidney27 / 211777127
larynx1 / 2414541
liver13 / 20774362
lung54 / 336974160
lymph0 / 442700 
lymph node6 / 9161065
mammary gland16 / 153271104
mouth4 / 6705259
muscle3 / 10771527
nerve6 / 15768380
ovary9 / 10205188
pancreas45 / 214812209
parathyroid1 / 2053948
pharynx4 / 4132896
pituitary gland1 / 1658560
placenta59 / 280825210
prostate16 / 18934584
salivary gland1 / 2015549
skin18 / 21057485
spleen6 / 53952111
stomach10 / 96619103
testis34 / 330442102
thymus6 / 8113173
thyroid0 / 474730 
tonsil0 / 169990 
trachea17 / 52413324
umbilical cord3 / 13680219
uterus25 / 232878107
vascular7 / 51780135
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201647_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.9
Adipocyte53.8
AdrenalCortex6.85
Adrenalgland5
Amygdala19.75
Appendix10.55
AtrioventricularNode5.9
BDCA4+_DentriticCells130.95
Bonemarrow6.3
BronchialEpithelialCells7.25
CD105+_Endothelial6.1
CD14+_Monocytes9.65
CD19+_BCells(neg._sel.)6.3
CD33+_Myeloid16.95
CD34+7.2
CD4+_Tcells6.2
CD56+_NKCells7.05
CD71+_EarlyErythroid5.9
CD8+_Tcells5.6
CardiacMyocytes9.7
Caudatenucleus5.9
Cerebellum5.05
CerebellumPeduncles8.15
CiliaryGanglion5.8
CingulateCortex6.9
Colorectaladenocarcinoma6.25
DorsalRootGanglion5.55
FetalThyroid6.1
Fetalbrain5.95
Fetalliver6.4
Fetallung13.25
GlobusPallidus4.85
Heart7.75
Hypothalamus11.6
Kidney5.2
Leukemia_chronicMyelogenousK-5625.1
Leukemia_promyelocytic-HL-605.05
Leukemialymphoblastic(MOLT-4)4.4
Liver7.7
Lung6.7
Lymphnode5.35
Lymphoma_burkitts(Daudi)7.35
Lymphoma_burkitts(Raji)8.15
MedullaOblongata8.25
OccipitalLobe9.05
OlfactoryBulb5.35
Ovary4.7
Pancreas5.2
PancreaticIslet48.85
ParietalLobe9.45
Pituitary6.7
Placenta40.25
Pons5.8
PrefrontalCortex9.05
Prostate8
Salivarygland5.05
SkeletalMuscle8.6
Skin5.65
SmoothMuscle12.5
Spinalcord6.3
SubthalamicNucleus5.85
SuperiorCervicalGanglion8.1
TemporalLobe5.45
Testis5.25
TestisGermCell6
TestisIntersitial5.05
TestisLeydigCell5.95
TestisSeminiferousTubule5.2
Thalamus6.1
Thymus4.45
Thyroid11.85
Tongue6.5
Tonsil5.7
Trachea9.55
TrigeminalGanglion10.35
Uterus9.7
UterusCorpus5.7
WholeBlood6.25
Wholebrain5.1
colon44.85
pineal_day112.42
pineal_night139.82
retina11.75
small_intestine17.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P54879
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.24 ± 0.51
Basal Forebrain7.76 ± 0.36
Basal Part of Pons7.81 ± 0.41
Cerebellar Cortex7.38 ± 0.22
Cerebellar Nuclei8.38 ± 0.34
Claustrum7.04 ± 0.55
Epithalamus7.77 ± 0.48
Frontal Lobe7.77 ± 0.45
Globus Pallidus8.62 ± 0.28
Hypothalamus7.96 ± 0.19
Insula7.65 ± 0.29
Limbic Lobe7.33 ± 0.48
Mesencephalon7.74 ± 0.46
Myelencephalon7.69 ± 0.42
Occipital Lobe7.37 ± 0.41
Parietal Lobe7.66 ± 0.45
Pontine Tegmentum7.78 ± 0.29
Striatum7.71 ± 0.38
Subthalamus8.11 ± 0.36
Temporal Lobe7.57 ± 0.37
Thalamus7.86 ± 0.33
White Matter9.73 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Scarb2CBCerebellum48.14
73.33
Scarb2CTXCerebral cortex100
100
Scarb2HIPHippocampal region63.18
93.7
Scarb2HPFHippocampal formation78.35
96.48
Scarb2HYHypothalamus100
100
Scarb2LSXLateral septal complex92.96
88.81
Scarb2MBMidbrain90.92
94.43
Scarb2MYMedulla87.41
100
Scarb2OLFOlfactory bulb94.57
97.89
Scarb2PPons90.83
100
Scarb2PALPallidum100
100
Scarb2RHPRetrohippocampal region100
100
Scarb2sAMYStriatum-like amygdalar nuclei100
98.35
Scarb2STRStriatum64.45
60.21
Scarb2STRdStriatum dorsal region50.8
48.01
Scarb2STRvStriatum ventral region65.7
56.6
Scarb2THThalamus96.11
96.68
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001234 18 245 262 CNMINGTDGDSFHPLITK Peptide Atlas
SCRB2_HUMAN_115 14 115 128 AYVFERDQSVGDPK PRIDE
SCRB2_HUMAN_115 19 115 133 AYVFERDQSVGDPKIDLIR PRIDE
SCRB2_HUMAN_127 7 127 133 PKIDLIR PRIDE
SCRB2_HUMAN_330 18 330 347 NGAPIIMSFPHFYQADER PRIDE
SCRB2_HUMAN_348 30 348 377 FVSAIEGMHPNQEDHETFVDINPLTGIILK PRIDE
SCRB2_HUMAN_390 12 390 401 KLDDFVETGDIR PRIDE
SCRB2_HUMAN_77 15 77 91 GETPRVEEVGPYTYR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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