AutismKB 2.0

Annotation Detail for ADAMTS1


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Basic Information Top
Gene Symbol:ADAMTS1 ( C3-C5,KIAA1346,METH1 )
Gene Full Name: ADAM metallopeptidase with thrombospondin type 1 motif, 1
Band: 21q21.3
Quick LinksEntrez ID:9510; OMIM: 605174; Uniprot ID:ATS1_HUMAN; ENSEMBL ID: ENSG00000154734; HGNC ID: 217
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst0 / 623190 
fetus36 / 56401263
neonate2 / 3109764
infant0 / 236200 
juvenile6 / 55556107
adult170 / 193912187
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma31 / 82823374
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor1 / 2638453
glioma4 / 10688337
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal246 / 336030773
ovarian tumor1 / 7668213
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer24 / 102680233
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor22 / 90257243
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites0 / 400150 
bladder2 / 2975767
blood0 / 1234780 
bone8 / 71655111
bone marrow1 / 4880120
brain37 / 110098933
cervix1 / 4817120
connective tissue32 / 149255214
ear1 / 1621261
embryonic tissue9 / 21572241
esophagus1 / 2020949
eye12 / 21105456
heart14 / 89626156
intestine5 / 23447221
kidney11 / 21177751
larynx1 / 2414541
liver6 / 20774328
lung27 / 33697480
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle9 / 10771583
nerve6 / 15768380
ovary5 / 10205148
pancreas17 / 21481279
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta38 / 280825135
prostate34 / 189345179
salivary gland0 / 201550 
skin12 / 21057456
spleen0 / 539520 
stomach4 / 9661941
testis8 / 33044224
thymus4 / 8113149
thyroid2 / 4747342
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord0 / 136800 
uterus55 / 232878236
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 222162_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.2
Adipocyte402.55
AdrenalCortex477.15
Adrenalgland47.9
Amygdala31.75
Appendix323.9
AtrioventricularNode155.55
BDCA4+_DentriticCells7.4
Bonemarrow11.1
BronchialEpithelialCells961.65
CD105+_Endothelial8.9
CD14+_Monocytes8.4
CD19+_BCells(neg._sel.)9.4
CD33+_Myeloid8.95
CD34+8.65
CD4+_Tcells9.95
CD56+_NKCells27.35
CD71+_EarlyErythroid8.8
CD8+_Tcells9.65
CardiacMyocytes42.6
Caudatenucleus12.8
Cerebellum12.95
CerebellumPeduncles18.35
CiliaryGanglion349.8
CingulateCortex21.9
Colorectaladenocarcinoma7.35
DorsalRootGanglion117.55
FetalThyroid63.35
Fetalbrain12.2
Fetalliver14.35
Fetallung954.7
GlobusPallidus29.3
Heart15.45
Hypothalamus80.3
Kidney10.15
Leukemia_chronicMyelogenousK-5628.7
Leukemia_promyelocytic-HL-6010.75
Leukemialymphoblastic(MOLT-4)10.75
Liver12.15
Lung156.15
Lymphnode90.25
Lymphoma_burkitts(Daudi)12.25
Lymphoma_burkitts(Raji)12.7
MedullaOblongata18.8
OccipitalLobe53.3
OlfactoryBulb265.3
Ovary1700.8
Pancreas103.1
PancreaticIslet198.1
ParietalLobe25.3
Pituitary34.1
Placenta955.4
Pons28.55
PrefrontalCortex55.4
Prostate308.15
Salivarygland14.35
SkeletalMuscle28.55
Skin33.55
SmoothMuscle888.9
Spinalcord164.15
SubthalamicNucleus35.6
SuperiorCervicalGanglion113.95
TemporalLobe43.55
Testis8.5
TestisGermCell78.5
TestisIntersitial32.35
TestisLeydigCell43.95
TestisSeminiferousTubule80.45
Thalamus23.85
Thymus18.95
Thyroid57.8
Tongue99.8
Tonsil11.45
Trachea64
TrigeminalGanglion144.2
Uterus527.6
UterusCorpus849.75
WholeBlood8.55
Wholebrain16.95
colon14.05
pineal_day16.2
pineal_night35.66
retina105.75
small_intestine39.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P211039
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.75 ± 0.61
Basal Forebrain6.16 ± 0.31
Basal Part of Pons5.84 ± 0.26
Cerebellar Cortex6.05 ± 0.37
Cerebellar Nuclei6.46 ± 0.31
Claustrum5.93 ± 0.84
Epithalamus5.49 ± 0.59
Frontal Lobe6.18 ± 0.72
Globus Pallidus7.46 ± 0.22
Hypothalamus5.55 ± 0.68
Insula6.1 ± 0.42
Limbic Lobe6.34 ± 0.67
Mesencephalon6.26 ± 0.55
Myelencephalon6.23 ± 0.48
Occipital Lobe6.22 ± 0.51
Parietal Lobe6.18 ± 0.54
Pontine Tegmentum6.29 ± 0.67
Striatum6.49 ± 0.52
Subthalamus6.42 ± 0.12
Temporal Lobe6.08 ± 0.5
Thalamus6.37 ± 0.43
White Matter8.67 ± 0.28
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Adamts1CBCerebellum3.21
2.88
Adamts1CTXCerebral cortex4.18
2.17
Adamts1HIPHippocampal region12.22
6.89
Adamts1HPFHippocampal formation9.17
5.04
Adamts1HYHypothalamus2.65
1.6
Adamts1LSXLateral septal complex2.89
1.42
Adamts1MBMidbrain1.79
1.37
Adamts1MYMedulla7.27
4.24
Adamts1OLFOlfactory bulb9.27
4.65
Adamts1PPons6.54
3.59
Adamts1PALPallidum1.93
1.18
Adamts1RHPRetrohippocampal region5.02
2.84
Adamts1sAMYStriatum-like amygdalar nuclei6.12
3.24
Adamts1STRStriatum3.48
1.75
Adamts1STRdStriatum dorsal region3.46
1.74
Adamts1STRvStriatum ventral region2.33
1.13
Adamts1THThalamus4.09
2.41
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00028070 15 620 634 TFREEQCEAHNEFSK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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