AutismKB 2.0

Annotation Detail for GDF15


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Basic Information Top
Gene Symbol:GDF15 ( GDF-15,MIC-1,MIC1,NAG-1,PDF,PLAB,PTGFB )
Gene Full Name: growth differentiation factor 15
Band: 19p13.11
Quick LinksEntrez ID:9518; OMIM: 605312; Uniprot ID:GDF15_HUMAN; ENSEMBL ID: ENSG00000130513; HGNC ID: 30142
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst2 / 6231932
fetus29 / 56401251
neonate3 / 3109796
infant2 / 2362084
juvenile2 / 5555635
adult739 / 1939121381
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor4 / 34366116
chondrosarcoma32 / 82823386
colorectal tumor16 / 114246140
esophageal tumor0 / 172900 
gastrointestinal tumor30 / 119369251
germ cell tumor11 / 26384541
glioma10 / 10688393
head and neck tumor0 / 1363020 
kidney tumor5 / 6895972
leukemia1 / 9584210
liver tumor46 / 96359477
lung tumor18 / 103127174
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal742 / 3360307220
ovarian tumor2 / 7668226
pancreatic tumor30 / 104616286
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer43 / 102680418
retinoblastoma3 / 4635664
skin tumor126 / 1249491008
soft tissue/muscle tissue tumor49 / 125191391
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites10 / 40015249
bladder1 / 2975733
blood1 / 1234788
bone2 / 7165527
bone marrow0 / 488010 
brain13 / 110098911
cervix4 / 4817183
connective tissue21 / 149255140
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye12 / 21105456
heart1 / 8962611
intestine70 / 234472298
kidney61 / 211777288
larynx0 / 241450 
liver53 / 207743255
lung92 / 336974273
lymph1 / 4427022
lymph node1 / 9161010
mammary gland4 / 15327126
mouth0 / 670520 
muscle30 / 107715278
nerve0 / 157680 
ovary3 / 10205129
pancreas35 / 214812162
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta578 / 2808252058
prostate53 / 189345279
salivary gland0 / 201550 
skin144 / 210574683
spleen1 / 5395218
stomach21 / 96619217
testis5 / 33044215
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord3 / 13680219
uterus19 / 23287881
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221577_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.2
Adipocyte6.9
AdrenalCortex7.55
Adrenalgland6.05
Amygdala6.9
Appendix8.65
AtrioventricularNode5.9
BDCA4+_DentriticCells7.2
Bonemarrow6.95
BronchialEpithelialCells83.15
CD105+_Endothelial6.95
CD14+_Monocytes6.5
CD19+_BCells(neg._sel.)7.25
CD33+_Myeloid7.35
CD34+8.15
CD4+_Tcells7
CD56+_NKCells7.6
CD71+_EarlyErythroid6.35
CD8+_Tcells6.05
CardiacMyocytes36.95
Caudatenucleus6.25
Cerebellum5.45
CerebellumPeduncles7.9
CiliaryGanglion5.95
CingulateCortex7.15
Colorectaladenocarcinoma75.95
DorsalRootGanglion5.75
FetalThyroid6.85
Fetalbrain6.75
Fetalliver10.75
Fetallung246.65
GlobusPallidus5.05
Heart9.5
Hypothalamus7.1
Kidney288.4
Leukemia_chronicMyelogenousK-562941.2
Leukemia_promyelocytic-HL-606.05
Leukemialymphoblastic(MOLT-4)5.45
Liver9.3
Lung515.9
Lymphnode6.2
Lymphoma_burkitts(Daudi)8.75
Lymphoma_burkitts(Raji)28.9
MedullaOblongata5.5
OccipitalLobe6
OlfactoryBulb7.95
Ovary4.65
Pancreas282.2
PancreaticIslet405.15
ParietalLobe7.45
Pituitary7.85
Placenta11135.05
Pons6.65
PrefrontalCortex8.3
Prostate494.35
Salivarygland18.8
SkeletalMuscle8.45
Skin6.7
SmoothMuscle62.8
Spinalcord7.3
SubthalamicNucleus6.3
SuperiorCervicalGanglion8.25
TemporalLobe6.35
Testis5.9
TestisGermCell5.8
TestisIntersitial5.75
TestisLeydigCell6.9
TestisSeminiferousTubule9.3
Thalamus7.1
Thymus5.35
Thyroid8.95
Tongue6.9
Tonsil6.7
Trachea14.1
TrigeminalGanglion8.75
Uterus5.9
UterusCorpus30.8
WholeBlood7.4
Wholebrain5.5
colon7.45
pineal_day8.48
pineal_night8.42
retina9.925
small_intestine6.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16895_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.21 ± 1.05
Basal Forebrain1.8 ± 0.32
Basal Part of Pons1.4 ± 0.32
Cerebellar Cortex1.66 ± 0.77
Cerebellar Nuclei2.03 ± 0.74
Claustrum2.68 ± 0.82
Epithalamus1.44 ± 0.78
Frontal Lobe1.59 ± 0.63
Globus Pallidus2.55 ± 0.73
Hypothalamus1.9 ± 0.66
Insula1.62 ± 0.52
Limbic Lobe1.79 ± 0.66
Mesencephalon1.96 ± 0.75
Myelencephalon1.82 ± 0.7
Occipital Lobe1.94 ± 0.72
Parietal Lobe1.85 ± 0.82
Pontine Tegmentum1.89 ± 0.74
Striatum1.87 ± 0.52
Subthalamus1.93 ± 0.72
Temporal Lobe1.71 ± 0.73
Thalamus1.78 ± 0.64
White Matter2.22 ± 0.24
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gdf15CBCerebellum1.07
1.55
Gdf15CTXCerebral cortex0.74
0.75
Gdf15HIPHippocampal region0.28
0.35
Gdf15HPFHippocampal formation0.35
0.56
Gdf15HYHypothalamus0.54
0.28
Gdf15LSXLateral septal complex0.11
0.08
Gdf15MBMidbrain0.63
0.62
Gdf15MYMedulla1.04
0.93
Gdf15OLFOlfactory bulb1.89
2.54
Gdf15PPons0.58
0.39
Gdf15PALPallidum0.51
0.34
Gdf15RHPRetrohippocampal region0.4
0.82
Gdf15sAMYStriatum-like amygdalar nuclei0.35
0.26
Gdf15STRStriatum0.26
0.21
Gdf15STRdStriatum dorsal region0.21
0.2
Gdf15STRvStriatum ventral region0.51
0.31
Gdf15THThalamus0.3
0.24
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00026972 11 199 209 NGDHCPLGPGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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