AutismKB 2.0

Annotation Detail for TBPL1


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Basic Information Top
Gene Symbol:TBPL1 ( MGC:8389,MGC:9620,STUD,TLF,TLP,TRF2 )
Gene Full Name: TBP-like 1
Band: 6q23.2
Quick LinksEntrez ID:9519; OMIM: 605521; Uniprot ID:TBPL1_HUMAN; ENSEMBL ID: ENSG00000028839; HGNC ID: 11589
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus12 / 56401221
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult70 / 193912136
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma3 / 17475171
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor11 / 26384541
glioma2 / 10688318
head and neck tumor2 / 13630214
kidney tumor5 / 6895972
leukemia18 / 95842187
liver tumor4 / 9635941
lung tumor5 / 10312748
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal126 / 336030737
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer3 / 10268029
retinoblastoma3 / 4635664
skin tumor3 / 12494924
soft tissue/muscle tissue tumor16 / 125191127
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder1 / 2975733
blood10 / 12347880
bone3 / 7165541
bone marrow15 / 48801307
brain42 / 110098938
cervix0 / 481710 
connective tissue15 / 149255100
ear0 / 162120 
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye6 / 21105428
heart0 / 896260 
intestine2 / 2344728
kidney9 / 21177742
larynx2 / 2414582
liver6 / 20774328
lung10 / 33697429
lymph0 / 442700 
lymph node7 / 9161076
mammary gland2 / 15327113
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas4 / 21481218
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta11 / 28082539
prostate5 / 18934526
salivary gland11 / 20155545
skin3 / 21057414
spleen0 / 539520 
stomach0 / 966190 
testis35 / 330442105
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208398_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts68.2
Adipocyte9.1
AdrenalCortex9.1
Adrenalgland7
Amygdala54.15
Appendix13.55
AtrioventricularNode6.8
BDCA4+_DentriticCells28.55
Bonemarrow20.8
BronchialEpithelialCells51.55
CD105+_Endothelial88.95
CD14+_Monocytes34.05
CD19+_BCells(neg._sel.)77.4
CD33+_Myeloid45.9
CD34+29.1
CD4+_Tcells29.6
CD56+_NKCells71.85
CD71+_EarlyErythroid177
CD8+_Tcells51.65
CardiacMyocytes11.65
Caudatenucleus13.15
Cerebellum13.4
CerebellumPeduncles14.15
CiliaryGanglion7.05
CingulateCortex24.75
Colorectaladenocarcinoma8.5
DorsalRootGanglion7.1
FetalThyroid9.2
Fetalbrain29.25
Fetalliver34.8
Fetallung8.05
GlobusPallidus10.35
Heart11.75
Hypothalamus30.2
Kidney9.7
Leukemia_chronicMyelogenousK-562211.6
Leukemia_promyelocytic-HL-6057.65
Leukemialymphoblastic(MOLT-4)24.55
Liver11
Lung14.2
Lymphnode20.45
Lymphoma_burkitts(Daudi)95.15
Lymphoma_burkitts(Raji)34.6
MedullaOblongata13.15
OccipitalLobe19.95
OlfactoryBulb7.15
Ovary5.4
Pancreas7.5
PancreaticIslet11.35
ParietalLobe9.45
Pituitary17.55
Placenta10.25
Pons17.65
PrefrontalCortex49.9
Prostate22.6
Salivarygland6.2
SkeletalMuscle10.6
Skin7.1
SmoothMuscle30.45
Spinalcord15.15
SubthalamicNucleus10
SuperiorCervicalGanglion11.05
TemporalLobe23.65
Testis666.35
TestisGermCell283.6
TestisIntersitial694.5
TestisLeydigCell392.55
TestisSeminiferousTubule296.95
Thalamus31.55
Thymus24.3
Thyroid15.3
Tongue8.8
Tonsil9.05
Trachea7.95
TrigeminalGanglion9.15
Uterus17
UterusCorpus8
WholeBlood65.35
Wholebrain80.3
colon12.05
pineal_day55.88
pineal_night54.88
retina13.275
small_intestine13.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15923_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.09 ± 0.51
Basal Forebrain5.81 ± 0.39
Basal Part of Pons6.4 ± 0.33
Cerebellar Cortex6.26 ± 0.25
Cerebellar Nuclei5.63 ± 0.57
Claustrum5.77 ± 0.42
Epithalamus5.7 ± 0.31
Frontal Lobe6.15 ± 0.4
Globus Pallidus5.34 ± 0.41
Hypothalamus6.15 ± 0.35
Insula6.37 ± 0.52
Limbic Lobe6.14 ± 0.55
Mesencephalon5.77 ± 0.49
Myelencephalon5.86 ± 0.57
Occipital Lobe5.45 ± 0.62
Parietal Lobe5.97 ± 0.38
Pontine Tegmentum5.95 ± 0.48
Striatum5.23 ± 0.55
Subthalamus6.43 ± 0.11
Temporal Lobe6.14 ± 0.38
Thalamus5.85 ± 0.38
White Matter5.31 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tbpl1CBCerebellum35.63
40.89
Tbpl1CTXCerebral cortex75.82
60.15
Tbpl1HIPHippocampal region46.98
72.56
Tbpl1HPFHippocampal formation50.45
62.07
Tbpl1HYHypothalamus36.01
29.96
Tbpl1LSXLateral septal complex65.41
63.9
Tbpl1MBMidbrain29.03
26.49
Tbpl1MYMedulla33.9
37.62
Tbpl1OLFOlfactory bulb84.42
76.6
Tbpl1PPons30.95
35.45
Tbpl1PALPallidum37.3
32.29
Tbpl1RHPRetrohippocampal region58.2
48.05
Tbpl1sAMYStriatum-like amygdalar nuclei57.9
50.07
Tbpl1STRStriatum38.58
29.85
Tbpl1STRdStriatum dorsal region26.42
18.78
Tbpl1STRvStriatum ventral region55.53
38.77
Tbpl1THThalamus38.64
33.13
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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