AutismKB 2.0

Annotation Detail for BAG3


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Basic Information Top
Gene Symbol:BAG3 ( BAG-3,BIS,CAIR-1,MGC104307 )
Gene Full Name: BCL2-associated athanogene 3
Band: 10q26.11
Quick LinksEntrez ID:9531; OMIM: 603883; Uniprot ID:BAG3_HUMAN; ENSEMBL ID: ENSG00000151929; HGNC ID: 939
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst3 / 6231948
fetus12 / 56401221
neonate4 / 31097128
infant1 / 2362042
juvenile7 / 55556125
adult157 / 193912180
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor9 / 9417895
cervical tumor1 / 3436629
chondrosarcoma8 / 8282396
colorectal tumor5 / 11424643
esophageal tumor2 / 17290115
gastrointestinal tumor10 / 11936983
germ cell tumor14 / 26384553
glioma16 / 106883149
head and neck tumor14 / 136302102
kidney tumor6 / 6895987
leukemia6 / 9584262
liver tumor4 / 9635941
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal235 / 336030769
ovarian tumor1 / 7668213
pancreatic tumor18 / 104616172
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor13 / 124949104
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue5 / 13106381
adrenal gland2 / 3319760
ascites1 / 4001524
bladder1 / 2975733
blood10 / 12347880
bone6 / 7165583
bone marrow5 / 48801102
brain60 / 110098954
cervix1 / 4817120
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue15 / 21572269
esophagus2 / 2020998
eye10 / 21105447
heart9 / 89626100
intestine12 / 23447251
kidney16 / 21177775
larynx0 / 241450 
liver6 / 20774328
lung20 / 33697459
lymph0 / 442700 
lymph node5 / 9161054
mammary gland12 / 15327178
mouth16 / 67052238
muscle6 / 10771555
nerve4 / 15768253
ovary1 / 1020519
pancreas26 / 214812121
parathyroid6 / 20539292
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta20 / 28082571
prostate13 / 18934568
salivary gland0 / 201550 
skin29 / 210574137
spleen2 / 5395237
stomach9 / 9661993
testis17 / 33044251
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord1 / 1368073
uterus26 / 232878111
vascular19 / 51780366
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217911_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts12.9
Adipocyte75.75
AdrenalCortex24.2
Adrenalgland35.05
Amygdala61.35
Appendix17.95
AtrioventricularNode18.6
BDCA4+_DentriticCells12.4
Bonemarrow15.9
BronchialEpithelialCells276.95
CD105+_Endothelial11.65
CD14+_Monocytes12.7
CD19+_BCells(neg._sel.)13.75
CD33+_Myeloid18.15
CD34+13.45
CD4+_Tcells25.7
CD56+_NKCells14.45
CD71+_EarlyErythroid7.85
CD8+_Tcells17.3
CardiacMyocytes90.25
Caudatenucleus25.6
Cerebellum84.9
CerebellumPeduncles40
CiliaryGanglion40.35
CingulateCortex18.1
Colorectaladenocarcinoma34.15
DorsalRootGanglion16.7
FetalThyroid25.8
Fetalbrain15.85
Fetalliver13.35
Fetallung31.15
GlobusPallidus14.2
Heart339.65
Hypothalamus55.8
Kidney58.35
Leukemia_chronicMyelogenousK-56219
Leukemia_promyelocytic-HL-6012.05
Leukemialymphoblastic(MOLT-4)10.2
Liver58.6
Lung135.85
Lymphnode15.3
Lymphoma_burkitts(Daudi)13.6
Lymphoma_burkitts(Raji)16.55
MedullaOblongata14.55
OccipitalLobe14.4
OlfactoryBulb106.9
Ovary10.7
Pancreas27.5
PancreaticIslet74.05
ParietalLobe15.65
Pituitary44.1
Placenta156.55
Pons15.65
PrefrontalCortex69.1
Prostate196
Salivarygland15.1
SkeletalMuscle221.75
Skin16.95
SmoothMuscle122.35
Spinalcord123
SubthalamicNucleus15.65
SuperiorCervicalGanglion22.05
TemporalLobe18.6
Testis49.05
TestisGermCell22.55
TestisIntersitial19.75
TestisLeydigCell20.05
TestisSeminiferousTubule29.35
Thalamus23.85
Thymus23.1
Thyroid76.85
Tongue125.9
Tonsil19.85
Trachea61.45
TrigeminalGanglion18.95
Uterus116.9
UterusCorpus24.9
WholeBlood11.65
Wholebrain18.55
colon80.9
pineal_day63.82
pineal_night46.14
retina86.45
small_intestine44.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P47077
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.31 ± 0.54
Basal Forebrain5.45 ± 0.37
Basal Part of Pons5.6 ± 0.27
Cerebellar Cortex5.29 ± 0.52
Cerebellar Nuclei5.81 ± 0.41
Claustrum5.13 ± 0.71
Epithalamus5.72 ± 0.53
Frontal Lobe4.91 ± 0.57
Globus Pallidus6.69 ± 0.63
Hypothalamus5.52 ± 0.64
Insula4.99 ± 0.35
Limbic Lobe5 ± 0.71
Mesencephalon5.27 ± 0.7
Myelencephalon5.24 ± 0.5
Occipital Lobe5.06 ± 0.56
Parietal Lobe4.95 ± 0.68
Pontine Tegmentum5.08 ± 0.7
Striatum5.93 ± 0.8
Subthalamus5.25 ± 0.38
Temporal Lobe4.9 ± 0.57
Thalamus5.29 ± 0.53
White Matter5.45 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Bag3CBCerebellum38.37
62.63
Bag3CTXCerebral cortex29.53
21.55
Bag3HIPHippocampal region18.53
18.86
Bag3HPFHippocampal formation21.93
20.59
Bag3HYHypothalamus3.21
2.7
Bag3LSXLateral septal complex3.6
2.83
Bag3MBMidbrain5.44
7.02
Bag3MYMedulla20.2
31.03
Bag3OLFOlfactory bulb37.69
30.89
Bag3PPons22.35
34.08
Bag3PALPallidum9.07
10.46
Bag3RHPRetrohippocampal region28.2
23.31
Bag3sAMYStriatum-like amygdalar nuclei9.95
7.2
Bag3STRStriatum7.95
5.91
Bag3STRdStriatum dorsal region7.55
5.88
Bag3STRvStriatum ventral region10.3
6.69
Bag3THThalamus6.52
6.06
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
BAG3_HUMAN_194 10 194 203 SSLGSHQLPR PRIDE
BAG3_HUMAN_80 26 80 105 EGHPVYPQLRPGYIPIPVLHEGAENR PRIDE
PAp00002997 31 140 170 GMPETTQPDKQCGQVAAAAAAQPPASHGPER Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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