AutismKB 2.0

Annotation Detail for PTGES


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Basic Information Top
Gene Symbol:PTGES ( MGC10317,MGST-IV,MGST1-L1,MGST1L1,MPGES,PGES,PIG12,PP102,PP1294,TP53I12,mPGES-1 )
Gene Full Name: prostaglandin E synthase
Band: 9q34.11
Quick LinksEntrez ID:9536; OMIM: 605172; Uniprot ID:PTGES_HUMAN; ENSEMBL ID: ENSG00000148344; HGNC ID: 9599
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus5 / 5640128
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult53 / 193912127
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor3 / 3436687
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor3 / 26384511
glioma4 / 10688337
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor18 / 103127174
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal46 / 336030713
ovarian tumor1 / 7668213
pancreatic tumor13 / 104616124
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer16 / 102680155
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder1 / 2975733
blood0 / 1234780 
bone2 / 7165527
bone marrow0 / 488010 
brain11 / 11009899
cervix3 / 4817162
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus1 / 2020949
eye2 / 2110549
heart0 / 896260 
intestine2 / 2344728
kidney1 / 2117774
larynx0 / 241450 
liver4 / 20774319
lung21 / 33697462
lymph0 / 442700 
lymph node0 / 916100 
mammary gland7 / 15327145
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas13 / 21481260
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta21 / 28082574
prostate21 / 189345110
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus11 / 23287847
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210367_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.55
Adipocyte17.75
AdrenalCortex11.3
Adrenalgland8.1
Amygdala10.2
Appendix10.3
AtrioventricularNode13.75
BDCA4+_DentriticCells9.5
Bonemarrow9.95
BronchialEpithelialCells9.45
CD105+_Endothelial12
CD14+_Monocytes9.95
CD19+_BCells(neg._sel.)9.25
CD33+_Myeloid12.25
CD34+12.1
CD4+_Tcells10.3
CD56+_NKCells10.3
CD71+_EarlyErythroid8.85
CD8+_Tcells9.2
CardiacMyocytes11.8
Caudatenucleus9.6
Cerebellum7.75
CerebellumPeduncles10.75
CiliaryGanglion13.7
CingulateCortex9.7
Colorectaladenocarcinoma9.5
DorsalRootGanglion12
FetalThyroid9.15
Fetalbrain9.3
Fetalliver7.8
Fetallung7.65
GlobusPallidus7.25
Heart11.9
Hypothalamus9.4
Kidney7.55
Leukemia_chronicMyelogenousK-5628.5
Leukemia_promyelocytic-HL-607.9
Leukemialymphoblastic(MOLT-4)6.9
Liver12.65
Lung10.55
Lymphnode8
Lymphoma_burkitts(Daudi)12
Lymphoma_burkitts(Raji)14.45
MedullaOblongata8.4
OccipitalLobe8.4
OlfactoryBulb7.2
Ovary7.85
Pancreas7.65
PancreaticIslet11
ParietalLobe9.95
Pituitary11
Placenta40.35
Pons8.95
PrefrontalCortex11.7
Prostate11.15
Salivarygland9.65
SkeletalMuscle11.45
Skin11.65
SmoothMuscle32.2
Spinalcord10.05
SubthalamicNucleus8.55
SuperiorCervicalGanglion15.65
TemporalLobe9.35
Testis8.5
TestisGermCell17.9
TestisIntersitial9.8
TestisLeydigCell11
TestisSeminiferousTubule9.1
Thalamus9.6
Thymus7.4
Thyroid11.7
Tongue10.55
Tonsil12.9
Trachea7.85
TrigeminalGanglion18.4
Uterus7.7
UterusCorpus8.35
WholeBlood9.2
Wholebrain7.85
colon9.5
pineal_day11.7
pineal_night11.26
retina26.425
small_intestine9.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15742_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.03 ± 1.05
Basal Forebrain1.65 ± 0.41
Basal Part of Pons1.32 ± 0.3
Cerebellar Cortex1.6 ± 0.84
Cerebellar Nuclei1.99 ± 0.72
Claustrum2.64 ± 0.93
Epithalamus1.44 ± 0.92
Frontal Lobe1.52 ± 0.66
Globus Pallidus2.11 ± 0.28
Hypothalamus1.76 ± 0.61
Insula1.37 ± 0.45
Limbic Lobe1.68 ± 0.7
Mesencephalon1.82 ± 0.69
Myelencephalon1.75 ± 0.74
Occipital Lobe1.73 ± 0.75
Parietal Lobe1.66 ± 0.79
Pontine Tegmentum1.65 ± 0.64
Striatum1.74 ± 0.63
Subthalamus1.76 ± 0.65
Temporal Lobe1.66 ± 0.73
Thalamus1.65 ± 0.64
White Matter2.06 ± 0.32
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PtgesCBCerebellum32.99
38.27
PtgesCTXCerebral cortex83.66
64.06
PtgesHIPHippocampal region42.96
52.39
PtgesHPFHippocampal formation50.97
52.05
PtgesHYHypothalamus30.08
22.05
PtgesLSXLateral septal complex30.91
18.73
PtgesMBMidbrain24.11
19.28
PtgesMYMedulla39.68
38.66
PtgesOLFOlfactory bulb92.55
80.51
PtgesPPons27.84
25.08
PtgesPALPallidum46.64
38.75
PtgesRHPRetrohippocampal region63.57
51.71
PtgessAMYStriatum-like amygdalar nuclei47.87
35.86
PtgesSTRStriatum59.79
43.01
PtgesSTRdStriatum dorsal region52.46
37.32
PtgesSTRvStriatum ventral region95.55
66.85
PtgesTHThalamus39.66
30.9
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00010356 8 53 60 HGGPQYCR Peptide Atlas
PTGES_HUMAN_42 10 42 51 AFANPEDALR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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