AutismKB 2.0

Annotation Detail for H2AFY


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Basic Information Top
Gene Symbol:H2AFY ( H2A.y,H2A/y,H2AF12M,H2AFJ,MACROH2A1.1,mH2A1,macroH2A1.2 )
Gene Full Name: H2A histone family, member Y
Band: 5q31.1
Quick LinksEntrez ID:9555; OMIM: 610054; Uniprot ID:H2AY_HUMAN; ENSEMBL ID: ENSG00000113648; HGNC ID: 4740
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body20 / 70761282
blastocyst10 / 62319160
fetus103 / 564012182
neonate7 / 31097225
infant6 / 23620254
juvenile16 / 55556287
adult388 / 1939121200
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus0 / 5640120 
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult1 / 19391210 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma1 / 1747557
breast (mammary gland) tumor19 / 94178201
cervical tumor10 / 34366290
chondrosarcoma13 / 82823156
colorectal tumor33 / 114246288
esophageal tumor2 / 17290115
gastrointestinal tumor23 / 119369192
germ cell tumor44 / 263845166
glioma15 / 106883140
head and neck tumor20 / 136302146
kidney tumor14 / 68959203
leukemia51 / 95842532
liver tumor9 / 9635993
lung tumor33 / 103127319
lymphoma13 / 71755181
non-neoplasia7 / 9725071
normal519 / 3360307154
ovarian tumor30 / 76682391
pancreatic tumor24 / 104616229
primitive neuroectodermal tumor of the CNS31 / 125680246
prostate cancer40 / 102680389
retinoblastoma12 / 46356258
skin tumor33 / 124949264
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor22 / 90257243
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia4 / 9584241
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal10 / 33603072
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland7 / 33197210
ascites5 / 40015124
bladder2 / 2975767
blood84 / 123478680
bone17 / 71655237
bone marrow20 / 48801409
brain114 / 1100989103
cervix14 / 48171290
connective tissue10 / 14925566
ear1 / 1621261
embryonic tissue50 / 215722231
esophagus3 / 20209148
eye27 / 211054127
heart12 / 89626133
intestine56 / 234472238
kidney26 / 211777122
larynx4 / 24145165
liver18 / 20774386
lung86 / 336974255
lymph7 / 44270158
lymph node18 / 91610196
mammary gland31 / 153271202
mouth10 / 67052149
muscle10 / 10771592
nerve3 / 15768190
ovary31 / 102051303
pancreas41 / 214812190
parathyroid1 / 2053948
pharynx2 / 4132848
pituitary gland9 / 16585542
placenta62 / 280825220
prostate43 / 189345227
salivary gland1 / 2015549
skin39 / 210574185
spleen8 / 53952148
stomach18 / 96619186
testis26 / 33044278
thymus13 / 81131160
thyroid6 / 47473126
tonsil2 / 16999117
trachea1 / 5241319
umbilical cord4 / 13680292
uterus38 / 232878163
vascular4 / 5178077
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow3 / 4880161
brain3 / 11009892
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine2 / 2344728
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis5 / 33044215
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207168_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts1256.7
Adipocyte131.55
AdrenalCortex137.3
Adrenalgland217.4
Amygdala356.85
Appendix78.1
AtrioventricularNode18.5
BDCA4+_DentriticCells1734
Bonemarrow751.25
BronchialEpithelialCells990.95
CD105+_Endothelial1247.1
CD14+_Monocytes1742.35
CD19+_BCells(neg._sel.)669.7
CD33+_Myeloid2638.95
CD34+3336.25
CD4+_Tcells639.2
CD56+_NKCells795.9
CD71+_EarlyErythroid1049.2
CD8+_Tcells467
CardiacMyocytes149.6
Caudatenucleus157.7
Cerebellum343.45
CerebellumPeduncles328.45
CiliaryGanglion25.4
CingulateCortex292.8
Colorectaladenocarcinoma568.75
DorsalRootGanglion48.1
FetalThyroid174.45
Fetalbrain352.1
Fetalliver223.2
Fetallung421.8
GlobusPallidus103.55
Heart145.6
Hypothalamus411.35
Kidney119.85
Leukemia_chronicMyelogenousK-562325.9
Leukemia_promyelocytic-HL-60652.3
Leukemialymphoblastic(MOLT-4)1293.25
Liver108.4
Lung746.55
Lymphnode339.6
Lymphoma_burkitts(Daudi)823.35
Lymphoma_burkitts(Raji)432.3
MedullaOblongata146.45
OccipitalLobe186
OlfactoryBulb193.75
Ovary91.2
Pancreas345.7
PancreaticIslet371.6
ParietalLobe132.45
Pituitary326.25
Placenta434.5
Pons111.2
PrefrontalCortex391.95
Prostate386.35
Salivarygland174.15
SkeletalMuscle80.4
Skin73.4
SmoothMuscle242.3
Spinalcord207.65
SubthalamicNucleus162.2
SuperiorCervicalGanglion40.8
TemporalLobe172.25
Testis154.7
TestisGermCell180.95
TestisIntersitial56.95
TestisLeydigCell66.25
TestisSeminiferousTubule62.9
Thalamus191.4
Thymus1025.3
Thyroid376.25
Tongue315.4
Tonsil502.4
Trachea253.2
TrigeminalGanglion25.75
Uterus168.35
UterusCorpus175.05
WholeBlood1106.7
Wholebrain347.95
colon543.95
pineal_day1545.46
pineal_night1646.86
retina344.75
small_intestine719.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_4731_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.23 ± 0.41
Basal Forebrain6.59 ± 0.3
Basal Part of Pons6.51 ± 0.31
Cerebellar Cortex6.9 ± 0.27
Cerebellar Nuclei6.54 ± 0.2
Claustrum6.17 ± 0.48
Epithalamus6.88 ± 0.43
Frontal Lobe6.58 ± 0.35
Globus Pallidus6.07 ± 0.12
Hypothalamus7.1 ± 0.18
Insula6.51 ± 0.48
Limbic Lobe6.33 ± 0.3
Mesencephalon6.6 ± 0.41
Myelencephalon6.48 ± 0.35
Occipital Lobe6.25 ± 0.3
Parietal Lobe6.4 ± 0.35
Pontine Tegmentum6.42 ± 0.37
Striatum6.13 ± 0.4
Subthalamus6.45 ± 0.81
Temporal Lobe6.62 ± 0.3
Thalamus6.43 ± 0.28
White Matter5.91 ± 0.12
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
H2afyCBCerebellum22.45
49.85
H2afyCTXCerebral cortex50.83
38.75
H2afyHIPHippocampal region46.86
82.94
H2afyHPFHippocampal formation43.67
61.81
H2afyHYHypothalamus64.15
57.99
H2afyLSXLateral septal complex40.58
32.9
H2afyMBMidbrain31.51
31.05
H2afyMYMedulla9.86
11.39
H2afyOLFOlfactory bulb45.09
40.95
H2afyPPons21.61
24.4
H2afyPALPallidum49.26
46.28
H2afyRHPRetrohippocampal region36.49
31.68
H2afysAMYStriatum-like amygdalar nuclei81.97
65.54
H2afySTRStriatum42.74
33.7
H2afySTRdStriatum dorsal region33.69
26.55
H2afySTRvStriatum ventral region54.14
40.03
H2afyTHThalamus68.01
67.93
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
H2AY_HUMAN_15 12 15 26 SAKAGVIFPVGR PRIDE
PAp00005714 10 295 304 NCLALADDKK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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