AutismKB 2.0

Annotation Detail for CLOCK


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Basic Information Top
Gene Symbol:CLOCK ( KAT13D,KIAA0334,bHLHe8 )
Gene Full Name: clock homolog (mouse)
Band: 4q12
Quick LinksEntrez ID:9575; OMIM: 601851; Uniprot ID:CLOCK_HUMAN; ENSEMBL ID: ENSG00000134852; HGNC ID: 2082
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus11 / 56401219
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult49 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor4 / 26384515
glioma3 / 10688328
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal74 / 336030722
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone1 / 7165513
bone marrow1 / 4880120
brain17 / 110098915
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye0 / 2110540 
heart1 / 8962611
intestine4 / 23447217
kidney2 / 2117779
larynx0 / 241450 
liver5 / 20774324
lung2 / 3369745
lymph0 / 442700 
lymph node1 / 9161010
mammary gland5 / 15327132
mouth2 / 6705229
muscle10 / 10771592
nerve0 / 157680 
ovary4 / 10205139
pancreas2 / 2148129
parathyroid2 / 2053997
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta10 / 28082535
prostate14 / 18934573
salivary gland0 / 201550 
skin5 / 21057423
spleen0 / 539520 
stomach0 / 966190 
testis12 / 33044236
thymus1 / 8113112
thyroid0 / 474730 
tonsil1 / 1699958
trachea4 / 5241376
umbilical cord0 / 136800 
uterus13 / 23287855
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204980_at
Cell line Expression level Expression bar
721_B_lymphoblasts13.8
Adipocyte21.2
AdrenalCortex21.2
Adrenalgland21.35
Amygdala22.1
Appendix20.5
AtrioventricularNode12
BDCA4+_DentriticCells15.2
Bonemarrow16.2
BronchialEpithelialCells17.8
CD105+_Endothelial15.4
CD14+_Monocytes16.8
CD19+_BCells(neg._sel.)12.45
CD33+_Myeloid15.1
CD34+16.75
CD4+_Tcells12.6
CD56+_NKCells21.2
CD71+_EarlyErythroid7.85
CD8+_Tcells13.05
CardiacMyocytes19.85
Caudatenucleus15.2
Cerebellum13.7
CerebellumPeduncles20.6
CiliaryGanglion10.45
CingulateCortex24.35
Colorectaladenocarcinoma16.75
DorsalRootGanglion16.35
FetalThyroid26.15
Fetalbrain19
Fetalliver27.6
Fetallung14.25
GlobusPallidus16.05
Heart23.7
Hypothalamus20.75
Kidney13.05
Leukemia_chronicMyelogenousK-56212.7
Leukemia_promyelocytic-HL-6014.05
Leukemialymphoblastic(MOLT-4)12.65
Liver25.05
Lung20.7
Lymphnode14.3
Lymphoma_burkitts(Daudi)18.1
Lymphoma_burkitts(Raji)22.1
MedullaOblongata22.4
OccipitalLobe20
OlfactoryBulb21.4
Ovary11.65
Pancreas11.8
PancreaticIslet18.95
ParietalLobe23.4
Pituitary49.1
Placenta15.45
Pons28.35
PrefrontalCortex73.55
Prostate36.8
Salivarygland13.25
SkeletalMuscle18.85
Skin12.35
SmoothMuscle19.15
Spinalcord16.8
SubthalamicNucleus16.2
SuperiorCervicalGanglion23.55
TemporalLobe24.55
Testis14.8
TestisGermCell23.05
TestisIntersitial23.4
TestisLeydigCell21.65
TestisSeminiferousTubule45.45
Thalamus16.7
Thymus12
Thyroid20.75
Tongue17.8
Tonsil16.8
Trachea14.85
TrigeminalGanglion20.5
Uterus27.3
UterusCorpus17.7
WholeBlood15.85
Wholebrain16.95
colon18.8
pineal_day25.14
pineal_night32.78
retina22.875
small_intestine16.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16994_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.23 ± 0.74
Basal Forebrain4.14 ± 0.23
Basal Part of Pons4.08 ± 0.5
Cerebellar Cortex4.59 ± 0.2
Cerebellar Nuclei3.98 ± 0.32
Claustrum4.36 ± 0.63
Epithalamus4.3 ± 0.31
Frontal Lobe4.27 ± 0.44
Globus Pallidus3.77 ± 0.41
Hypothalamus3.99 ± 0.57
Insula4.29 ± 0.38
Limbic Lobe4.37 ± 0.44
Mesencephalon4.35 ± 0.43
Myelencephalon4.25 ± 0.44
Occipital Lobe4.57 ± 0.36
Parietal Lobe4.41 ± 0.42
Pontine Tegmentum4.26 ± 0.45
Striatum3.94 ± 0.53
Subthalamus4.2 ± 0.11
Temporal Lobe4.26 ± 0.42
Thalamus4.3 ± 0.41
White Matter3.88 ± 0.75
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
ClockCBCerebellum5.04
4.41
ClockCTXCerebral cortex6.38
3.85
ClockHIPHippocampal region37.06
22.72
ClockHPFHippocampal formation25.37
15.07
ClockHYHypothalamus3.12
1.84
ClockLSXLateral septal complex6.05
3.68
ClockMBMidbrain3.12
2.34
ClockMYMedulla8.87
8.61
ClockOLFOlfactory bulb13.09
7.31
ClockPPons8.25
7.2
ClockPALPallidum2.45
1.64
ClockRHPRetrohippocampal region9.39
6.17
ClocksAMYStriatum-like amygdalar nuclei2.6
1.37
ClockSTRStriatum4.77
2.63
ClockSTRdStriatum dorsal region4.24
2.29
ClockSTRvStriatum ventral region7.75
4.09
ClockTHThalamus4.79
3.16
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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