AutismKB 2.0

Annotation Detail for NFE2L3


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Basic Information Top
Gene Symbol:NFE2L3 ( NRF3 )
Gene Full Name: nuclear factor (erythroid-derived 2)-like 3
Band: 7p15.2
Quick LinksEntrez ID:9603; OMIM: 604135; Uniprot ID:NF2L3_HUMAN; ENSEMBL ID: ENSG00000050344; HGNC ID: 7783
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus7 / 56401212
neonate0 / 310970 
infant1 / 2362042
juvenile3 / 5555653
adult62 / 193912131
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus0 / 5640120 
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult2 / 19391211
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor18 / 114246157
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor14 / 26384553
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor4 / 9635941
lung tumor0 / 1031270 
lymphoma3 / 7175541
non-neoplasia0 / 972500 
normal56 / 336030716
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor2 / 9025722
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal6 / 33603071
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites4 / 4001599
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain3 / 11009892
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye2 / 2110549
heart6 / 8962666
intestine21 / 23447289
kidney7 / 21177733
larynx0 / 241450 
liver8 / 20774338
lung3 / 3369748
lymph2 / 4427045
lymph node2 / 9161021
mammary gland2 / 15327113
mouth0 / 670520 
muscle0 / 1077150 
nerve3 / 15768190
ovary1 / 1020519
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta21 / 28082574
prostate3 / 18934515
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach3 / 9661931
testis3 / 3304429
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain1 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine2 / 2344728
kidney0 / 2117770 
larynx0 / 241450 
liver1 / 2077434
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204702_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts13.95
Adipocyte8.7
AdrenalCortex14.45
Adrenalgland8.2
Amygdala7.85
Appendix11.55
AtrioventricularNode12.15
BDCA4+_DentriticCells8.7
Bonemarrow10.25
BronchialEpithelialCells8.35
CD105+_Endothelial8.75
CD14+_Monocytes11.35
CD19+_BCells(neg._sel.)8.9
CD33+_Myeloid10.3
CD34+12.65
CD4+_Tcells8.55
CD56+_NKCells9.15
CD71+_EarlyErythroid8.55
CD8+_Tcells7.65
CardiacMyocytes16.3
Caudatenucleus8
Cerebellum7.45
CerebellumPeduncles11
CiliaryGanglion10.9
CingulateCortex9.8
Colorectaladenocarcinoma564.5
DorsalRootGanglion10.15
FetalThyroid9.65
Fetalbrain8.2
Fetalliver7.8
Fetallung6.3
GlobusPallidus8.6
Heart15.2
Hypothalamus8.35
Kidney8.25
Leukemia_chronicMyelogenousK-5628.2
Leukemia_promyelocytic-HL-6016.5
Leukemialymphoblastic(MOLT-4)6.45
Liver15
Lung9.65
Lymphnode7.55
Lymphoma_burkitts(Daudi)12.55
Lymphoma_burkitts(Raji)17.8
MedullaOblongata8
OccipitalLobe7.85
OlfactoryBulb6.8
Ovary8.65
Pancreas10.55
PancreaticIslet9.75
ParietalLobe10.7
Pituitary10.5
Placenta38.7
Pons9.5
PrefrontalCortex9.35
Prostate9.65
Salivarygland7.7
SkeletalMuscle16.3
Skin11
SmoothMuscle9.9
Spinalcord9.5
SubthalamicNucleus9.35
SuperiorCervicalGanglion15.05
TemporalLobe9
Testis7.5
TestisGermCell7.05
TestisIntersitial8.15
TestisLeydigCell10.15
TestisSeminiferousTubule7.7
Thalamus9.4
Thymus6.55
Thyroid9.35
Tongue10.25
Tonsil9.25
Trachea7.2
TrigeminalGanglion16.8
Uterus7.05
UterusCorpus9.6
WholeBlood9.55
Wholebrain6.25
colon9.2
pineal_day24
pineal_night12.74
retina9.8
small_intestine9.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P136653
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.12 ± 1.01
Basal Forebrain1.66 ± 0.21
Basal Part of Pons1.38 ± 0.44
Cerebellar Cortex1.51 ± 0.66
Cerebellar Nuclei2.01 ± 0.74
Claustrum2.56 ± 0.87
Epithalamus1.42 ± 0.76
Frontal Lobe1.57 ± 0.73
Globus Pallidus2.25 ± 0.29
Hypothalamus1.7 ± 0.68
Insula1.69 ± 0.73
Limbic Lobe1.69 ± 0.65
Mesencephalon1.89 ± 0.74
Myelencephalon1.69 ± 0.64
Occipital Lobe1.67 ± 0.47
Parietal Lobe1.62 ± 0.55
Pontine Tegmentum1.72 ± 0.64
Striatum1.9 ± 0.63
Subthalamus1.87 ± 0.66
Temporal Lobe1.54 ± 0.57
Thalamus1.65 ± 0.56
White Matter2.59 ± 0.86
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nfe2l3CBCerebellum31.51
41.63
Nfe2l3CTXCerebral cortex8.29
5.65
Nfe2l3HIPHippocampal region7.25
7.02
Nfe2l3HPFHippocampal formation9.1
8.23
Nfe2l3HYHypothalamus4.66
3.73
Nfe2l3LSXLateral septal complex3.2
2.96
Nfe2l3MBMidbrain11.34
8.71
Nfe2l3MYMedulla23.3
19.98
Nfe2l3OLFOlfactory bulb10.9
8.85
Nfe2l3PPons14.76
13.12
Nfe2l3PALPallidum6.48
4.82
Nfe2l3RHPRetrohippocampal region13.25
10.81
Nfe2l3sAMYStriatum-like amygdalar nuclei1.9
1.43
Nfe2l3STRStriatum7.56
5.43
Nfe2l3STRdStriatum dorsal region8.47
6.23
Nfe2l3STRvStriatum ventral region8.65
5.49
Nfe2l3THThalamus24.32
19.3
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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