AutismKB 2.0

Annotation Detail for TCL1B


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Basic Information Top
Gene Symbol:TCL1B ( TML1 )
Gene Full Name: T-cell leukemia/lymphoma 1B
Band: 14q32.13
Quick LinksEntrez ID:9623; OMIM: 603769; Uniprot ID:TCL1B_HUMAN; ENSEMBL ID: ENSG00000213231; HGNC ID: 11649
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult3 / 19391211
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma16 / 71755222
non-neoplasia0 / 972500 
normal8 / 33603072
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain0 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph8 / 44270180
lymph node16 / 91610174
mammary gland2 / 15327113
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206413_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.65
Adipocyte5.4
AdrenalCortex5.9
Adrenalgland4.55
Amygdala5.8
Appendix5.35
AtrioventricularNode9.3
BDCA4+_DentriticCells8.1
Bonemarrow7.55
BronchialEpithelialCells5.45
CD105+_Endothelial5.55
CD14+_Monocytes9.2
CD19+_BCells(neg._sel.)7.35
CD33+_Myeloid7.05
CD34+6.9
CD4+_Tcells6
CD56+_NKCells6.55
CD71+_EarlyErythroid6.45
CD8+_Tcells5.35
CardiacMyocytes7.05
Caudatenucleus4.85
Cerebellum4.4
CerebellumPeduncles6.15
CiliaryGanglion3.75
CingulateCortex5.5
Colorectaladenocarcinoma5.55
DorsalRootGanglion4.15
FetalThyroid5.7
Fetalbrain5.45
Fetalliver4.75
Fetallung4.6
GlobusPallidus3.95
Heart6.8
Hypothalamus5.95
Kidney4.25
Leukemia_chronicMyelogenousK-5624.9
Leukemia_promyelocytic-HL-604.85
Leukemialymphoblastic(MOLT-4)4.9
Liver8.05
Lung10.7
Lymphnode4.8
Lymphoma_burkitts(Daudi)13.7
Lymphoma_burkitts(Raji)8.2
MedullaOblongata4.85
OccipitalLobe4.75
OlfactoryBulb4.55
Ovary3.65
Pancreas4.75
PancreaticIslet5.8
ParietalLobe5.25
Pituitary6.4
Placenta5.6
Pons5.15
PrefrontalCortex6.45
Prostate6.4
Salivarygland4.3
SkeletalMuscle6.75
Skin4.35
SmoothMuscle6.25
Spinalcord5.8
SubthalamicNucleus5.55
SuperiorCervicalGanglion5.95
TemporalLobe5.25
Testis4.7
TestisGermCell4.65
TestisIntersitial4.55
TestisLeydigCell5.4
TestisSeminiferousTubule4.8
Thalamus5.5
Thymus4.25
Thyroid6.9
Tongue5.25
Tonsil5.65
Trachea5.05
TrigeminalGanglion5.85
Uterus4.5
UterusCorpus5.35
WholeBlood6.05
Wholebrain4.4
colon5.5
pineal_day6.64
pineal_night6.6
retina6.55
small_intestine5.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10099_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.19 ± 1.11
Basal Forebrain1.82 ± 0.35
Basal Part of Pons1.38 ± 0.41
Cerebellar Cortex1.51 ± 0.76
Cerebellar Nuclei1.99 ± 0.76
Claustrum2.49 ± 0.76
Epithalamus1.51 ± 0.87
Frontal Lobe1.62 ± 0.87
Globus Pallidus2.21 ± 0.38
Hypothalamus1.78 ± 0.74
Insula1.53 ± 0.48
Limbic Lobe1.74 ± 0.7
Mesencephalon1.92 ± 0.8
Myelencephalon1.79 ± 0.71
Occipital Lobe1.93 ± 0.77
Parietal Lobe1.77 ± 0.78
Pontine Tegmentum1.78 ± 0.72
Striatum1.97 ± 0.63
Subthalamus1.8 ± 0.64
Temporal Lobe1.65 ± 0.71
Thalamus1.74 ± 0.61
White Matter2.21 ± 0.21
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018