AutismKB 2.0

Annotation Detail for ISG15


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Basic Information Top
Gene Symbol:ISG15 ( G1P2,IFI15,IP17,UCRP,hUCRP )
Gene Full Name: ISG15 ubiquitin-like modifier
Band: 1p36.33
Quick LinksEntrez ID:9636; OMIM: 147571; Uniprot ID:ISG15_HUMAN; ENSEMBL ID: ENSG00000187608; HGNC ID: 4053
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus9 / 56401215
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult118 / 193912160
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor19 / 94178201
cervical tumor5 / 34366145
chondrosarcoma3 / 8282336
colorectal tumor8 / 11424670
esophageal tumor2 / 17290115
gastrointestinal tumor3 / 11936925
germ cell tumor7 / 26384526
glioma7 / 10688365
head and neck tumor4 / 13630229
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor5 / 9635951
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia4 / 9725041
normal90 / 336030726
ovarian tumor5 / 7668265
pancreatic tumor11 / 104616105
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer9 / 10268087
retinoblastoma0 / 463560 
skin tumor6 / 12494948
soft tissue/muscle tissue tumor36 / 125191287
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites3 / 4001574
bladder0 / 297570 
blood1 / 1234788
bone3 / 7165541
bone marrow0 / 488010 
brain13 / 110098911
cervix5 / 48171103
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus2 / 2020998
eye6 / 21105428
heart5 / 8962655
intestine15 / 23447263
kidney2 / 2117779
larynx1 / 2414541
liver11 / 20774352
lung10 / 33697429
lymph1 / 4427022
lymph node0 / 916100 
mammary gland19 / 153271123
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary7 / 10205168
pancreas14 / 21481265
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta19 / 28082567
prostate18 / 18934595
salivary gland2 / 2015599
skin8 / 21057437
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus48 / 232878206
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205483_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts903.55
Adipocyte27.85
AdrenalCortex20.2
Adrenalgland19.1
Amygdala78.1
Appendix38.25
AtrioventricularNode10.9
BDCA4+_DentriticCells403.15
Bonemarrow41.25
BronchialEpithelialCells40.95
CD105+_Endothelial93.35
CD14+_Monocytes550.8
CD19+_BCells(neg._sel.)201.75
CD33+_Myeloid329.2
CD34+77
CD4+_Tcells366.85
CD56+_NKCells577.65
CD71+_EarlyErythroid28.1
CD8+_Tcells237.5
CardiacMyocytes19.4
Caudatenucleus30.25
Cerebellum10.3
CerebellumPeduncles14.05
CiliaryGanglion55
CingulateCortex45.15
Colorectaladenocarcinoma243.25
DorsalRootGanglion25.1
FetalThyroid18.8
Fetalbrain29.7
Fetalliver6.3
Fetallung26.45
GlobusPallidus16.85
Heart371.9
Hypothalamus99.75
Kidney14
Leukemia_chronicMyelogenousK-562125.1
Leukemia_promyelocytic-HL-6089.35
Leukemialymphoblastic(MOLT-4)27.75
Liver210.55
Lung1066
Lymphnode99.65
Lymphoma_burkitts(Daudi)2388.9
Lymphoma_burkitts(Raji)293.75
MedullaOblongata26.2
OccipitalLobe26.65
OlfactoryBulb29.75
Ovary8.65
Pancreas69.75
PancreaticIslet29.6
ParietalLobe17.15
Pituitary39.6
Placenta246.15
Pons24.65
PrefrontalCortex58.45
Prostate261.45
Salivarygland18.85
SkeletalMuscle15.25
Skin9.05
SmoothMuscle85.2
Spinalcord54.3
SubthalamicNucleus28.45
SuperiorCervicalGanglion32.65
TemporalLobe30.85
Testis16.6
TestisGermCell16.1
TestisIntersitial15
TestisLeydigCell10.5
TestisSeminiferousTubule8.35
Thalamus188.75
Thymus474.8
Thyroid99.7
Tongue134.55
Tonsil100.9
Trachea27.6
TrigeminalGanglion46.5
Uterus37.25
UterusCorpus17.7
WholeBlood325.35
Wholebrain98.1
colon58.55
pineal_day127.28
pineal_night149.32
retina53.575
small_intestine84.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P99533
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.45 ± 0.69
Basal Forebrain2.23 ± 0.67
Basal Part of Pons2.9 ± 0.68
Cerebellar Cortex1.75 ± 0.52
Cerebellar Nuclei2.78 ± 0.88
Claustrum2.6 ± 0.65
Epithalamus1.93 ± 1.19
Frontal Lobe2.24 ± 0.68
Globus Pallidus2.66 ± 1.13
Hypothalamus2.17 ± 0.86
Insula2.33 ± 0.48
Limbic Lobe2.24 ± 0.72
Mesencephalon2.23 ± 0.66
Myelencephalon2.43 ± 0.75
Occipital Lobe1.86 ± 0.72
Parietal Lobe2.28 ± 0.84
Pontine Tegmentum2.13 ± 0.78
Striatum2.1 ± 0.83
Subthalamus1.78 ± 0.72
Temporal Lobe2.5 ± 0.76
Thalamus2.63 ± 0.67
White Matter1.42 ± 0.48
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00008518 30 58 87 VPLASQGLGPGSTVLLVVDKCDEPLSILVR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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