AutismKB 2.0

Annotation Detail for ARHGEF10


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Basic Information Top
Gene Symbol:ARHGEF10 ( DKFZp686H0726,GEF10,MGC131664 )
Gene Full Name: Rho guanine nucleotide exchange factor (GEF) 10
Band: 8p23.3
Quick LinksEntrez ID:9639; OMIM: 608136; Uniprot ID:ARHGA_HUMAN; ENSEMBL ID: ENSG00000104728; HGNC ID: 14103
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst9 / 62319144
fetus19 / 56401233
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult91 / 193912146
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma10 / 82823120
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor16 / 26384560
glioma4 / 10688337
head and neck tumor2 / 13630214
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor3 / 9635931
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia6 / 9725061
normal139 / 336030741
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer1 / 1026809
retinoblastoma2 / 4635643
skin tumor3 / 12494924
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone11 / 71655153
bone marrow0 / 488010 
brain47 / 110098942
cervix1 / 4817120
connective tissue7 / 14925546
ear1 / 1621261
embryonic tissue22 / 215722101
esophagus0 / 202090 
eye6 / 21105428
heart5 / 8962655
intestine8 / 23447234
kidney10 / 21177747
larynx1 / 2414541
liver6 / 20774328
lung10 / 33697429
lymph0 / 442700 
lymph node0 / 916100 
mammary gland9 / 15327158
mouth0 / 670520 
muscle3 / 10771527
nerve1 / 1576863
ovary3 / 10205129
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta3 / 28082510
prostate11 / 18934558
salivary gland1 / 2015549
skin4 / 21057418
spleen0 / 539520 
stomach0 / 966190 
testis31 / 33044293
thymus19 / 81131234
thyroid0 / 474730 
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus14 / 23287860
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 216620_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.3
Adipocyte8.85
AdrenalCortex4.25
Adrenalgland3.8
Amygdala8.85
Appendix7.2
AtrioventricularNode14.5
BDCA4+_DentriticCells4.1
Bonemarrow4.15
BronchialEpithelialCells10.65
CD105+_Endothelial6.15
CD14+_Monocytes4.1
CD19+_BCells(neg._sel.)4.5
CD33+_Myeloid4.65
CD34+9.15
CD4+_Tcells4.6
CD56+_NKCells7.7
CD71+_EarlyErythroid3.6
CD8+_Tcells4.3
CardiacMyocytes6
Caudatenucleus6.65
Cerebellum3.45
CerebellumPeduncles4.55
CiliaryGanglion3.6
CingulateCortex7.25
Colorectaladenocarcinoma4.5
DorsalRootGanglion13.8
FetalThyroid12.3
Fetalbrain7.3
Fetalliver3.6
Fetallung19.35
GlobusPallidus3
Heart5.2
Hypothalamus16.25
Kidney3.35
Leukemia_chronicMyelogenousK-56218.75
Leukemia_promyelocytic-HL-603.55
Leukemialymphoblastic(MOLT-4)43.8
Liver5.25
Lung18.55
Lymphnode5.9
Lymphoma_burkitts(Daudi)5.15
Lymphoma_burkitts(Raji)9.3
MedullaOblongata9.3
OccipitalLobe6.05
OlfactoryBulb133.35
Ovary2.95
Pancreas3.05
PancreaticIslet5.35
ParietalLobe7.65
Pituitary5.7
Placenta5.15
Pons4.85
PrefrontalCortex19.8
Prostate23.85
Salivarygland3.7
SkeletalMuscle4.75
Skin3.2
SmoothMuscle19.9
Spinalcord42.5
SubthalamicNucleus3.65
SuperiorCervicalGanglion7.15
TemporalLobe5.5
Testis29.05
TestisGermCell42.75
TestisIntersitial23.6
TestisLeydigCell5.35
TestisSeminiferousTubule14.15
Thalamus8.5
Thymus6.05
Thyroid7
Tongue4.2
Tonsil4.15
Trachea3.6
TrigeminalGanglion8.8
Uterus24.6
UterusCorpus4.1
WholeBlood4
Wholebrain19.75
colon4.95
pineal_day5.18
pineal_night5.34
retina20.575
small_intestine4.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_87_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.91 ± 0.58
Basal Forebrain5.57 ± 0.39
Basal Part of Pons4.64 ± 0.54
Cerebellar Cortex4.52 ± 0.39
Cerebellar Nuclei5.71 ± 0.67
Claustrum5.53 ± 0.68
Epithalamus5.43 ± 0.96
Frontal Lobe4.91 ± 0.62
Globus Pallidus6.5 ± 0.34
Hypothalamus5.03 ± 0.53
Insula4.75 ± 0.37
Limbic Lobe4.94 ± 0.79
Mesencephalon5.42 ± 0.56
Myelencephalon5.24 ± 0.71
Occipital Lobe5.42 ± 0.52
Parietal Lobe5.05 ± 0.63
Pontine Tegmentum5.22 ± 0.59
Striatum5.8 ± 0.59
Subthalamus5.36 ± 0.28
Temporal Lobe4.93 ± 0.55
Thalamus5.31 ± 0.39
White Matter7.15 ± 0.48
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00095421 14 1303 1316 ASSALVVCGGQGHR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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