AutismKB 2.0

Annotation Detail for MICAL2


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Basic Information Top
Gene Symbol:MICAL2 ( DKFZp686H03148,DKFZp686H2469,KIAA0750,MICAL2PV1,MICAL2PV2 )
Gene Full Name: microtubule associated monoxygenase, calponin and LIM domain containing 2
Band: 11p15.3
Quick LinksEntrez ID:9645; OMIM: 608881; Uniprot ID:MICA2_HUMAN; ENSEMBL ID: ENSG00000133816; HGNC ID: 24693
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst0 / 623190 
fetus36 / 56401263
neonate2 / 3109764
infant4 / 23620169
juvenile2 / 5555635
adult144 / 193912174
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma7 / 8282384
colorectal tumor15 / 114246131
esophageal tumor1 / 1729057
gastrointestinal tumor7 / 11936958
germ cell tumor2 / 2638457
glioma2 / 10688318
head and neck tumor9 / 13630266
kidney tumor9 / 68959130
leukemia5 / 9584252
liver tumor3 / 9635931
lung tumor6 / 10312758
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal260 / 336030777
ovarian tumor2 / 7668226
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer2 / 10268019
retinoblastoma3 / 4635664
skin tumor1 / 1249498
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder4 / 29757134
blood5 / 12347840
bone16 / 71655223
bone marrow6 / 48801122
brain100 / 110098990
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus1 / 2020949
eye23 / 211054108
heart7 / 8962678
intestine25 / 234472106
kidney14 / 21177766
larynx1 / 2414541
liver4 / 20774319
lung10 / 33697429
lymph0 / 442700 
lymph node0 / 916100 
mammary gland7 / 15327145
mouth4 / 6705259
muscle10 / 10771592
nerve1 / 1576863
ovary4 / 10205139
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta15 / 28082553
prostate5 / 18934526
salivary gland0 / 201550 
skin7 / 21057433
spleen2 / 5395237
stomach5 / 9661951
testis35 / 330442105
thymus3 / 8113136
thyroid4 / 4747384
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord2 / 13680146
uterus14 / 23287860
vascular7 / 51780135
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212473_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.4
Adipocyte29.55
AdrenalCortex37.4
Adrenalgland37.65
Amygdala758.15
Appendix23.5
AtrioventricularNode16
BDCA4+_DentriticCells36.65
Bonemarrow259.65
BronchialEpithelialCells232.85
CD105+_Endothelial263.6
CD14+_Monocytes267.9
CD19+_BCells(neg._sel.)9.95
CD33+_Myeloid213.15
CD34+61.05
CD4+_Tcells28.05
CD56+_NKCells65.4
CD71+_EarlyErythroid1048.3
CD8+_Tcells33.9
CardiacMyocytes1003.4
Caudatenucleus41.2
Cerebellum1707.1
CerebellumPeduncles1407.5
CiliaryGanglion11.95
CingulateCortex485.6
Colorectaladenocarcinoma239.15
DorsalRootGanglion10.3
FetalThyroid37.25
Fetalbrain119.65
Fetalliver118.2
Fetallung249.1
GlobusPallidus265.55
Heart190
Hypothalamus64.45
Kidney8.6
Leukemia_chronicMyelogenousK-562104.25
Leukemia_promyelocytic-HL-606.85
Leukemialymphoblastic(MOLT-4)7.3
Liver157.55
Lung379.2
Lymphnode25.5
Lymphoma_burkitts(Daudi)11.65
Lymphoma_burkitts(Raji)7.1
MedullaOblongata376.5
OccipitalLobe384.7
OlfactoryBulb24.2
Ovary29.55
Pancreas74.3
PancreaticIslet31.3
ParietalLobe368.4
Pituitary32.8
Placenta65.65
Pons175.65
PrefrontalCortex1167.65
Prostate65.25
Salivarygland6.1
SkeletalMuscle9.6
Skin8.95
SmoothMuscle1544.75
Spinalcord39.45
SubthalamicNucleus409.05
SuperiorCervicalGanglion12
TemporalLobe419.35
Testis374.8
TestisGermCell554.7
TestisIntersitial76.3
TestisLeydigCell86.65
TestisSeminiferousTubule211.35
Thalamus36.45
Thymus44.15
Thyroid92.2
Tongue6.5
Tonsil9.95
Trachea15.2
TrigeminalGanglion5.05
Uterus417
UterusCorpus106.85
WholeBlood285.9
Wholebrain938.2
colon540.1
pineal_day21.94
pineal_night35.42
retina42.525
small_intestine225.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P13442
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.03 ± 1.05
Basal Forebrain4.7 ± 0.46
Basal Part of Pons4.96 ± 0.6
Cerebellar Cortex6.47 ± 0.18
Cerebellar Nuclei4.71 ± 0.64
Claustrum6.07 ± 0.62
Epithalamus4.28 ± 0.98
Frontal Lobe5.66 ± 0.69
Globus Pallidus2.82 ± 1.12
Hypothalamus4.55 ± 0.7
Insula5.69 ± 0.42
Limbic Lobe6.24 ± 0.93
Mesencephalon5.17 ± 1.08
Myelencephalon5.4 ± 0.82
Occipital Lobe5.93 ± 0.57
Parietal Lobe5.73 ± 0.49
Pontine Tegmentum5.45 ± 0.85
Striatum3.27 ± 1.22
Subthalamus5.59 ± 0.5
Temporal Lobe5.94 ± 0.43
Thalamus4.71 ± 0.79
White Matter3.28 ± 0.48
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mical2CBCerebellum100
100
Mical2CTXCerebral cortex100
100
Mical2HIPHippocampal region100
100
Mical2HPFHippocampal formation100
100
Mical2HYHypothalamus52.04
45.65
Mical2LSXLateral septal complex41.64
31.87
Mical2MBMidbrain54.62
55.15
Mical2MYMedulla84.66
100
Mical2OLFOlfactory bulb100
100
Mical2PPons53.82
59.14
Mical2PALPallidum39.62
37.28
Mical2RHPRetrohippocampal region100
100
Mical2sAMYStriatum-like amygdalar nuclei78.7
78.22
Mical2STRStriatum47.18
40.65
Mical2STRdStriatum dorsal region42.94
37.05
Mical2STRvStriatum ventral region45.64
34.2
Mical2THThalamus83.64
82.19
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MICA2_HUMAN_666 12 666 677 VDGQTGENDMNK PRIDE
MICA2_HUMAN_831 12 831 842 PRAQALSGVLWR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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