AutismKB 2.0

Annotation Detail for PPM1F


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PPM1F ( CAMKP,CaMKPase,FEM-2,KIAA0015,POPX2,hFEM-2 )
Gene Full Name: protein phosphatase, Mg2+/Mn2+ dependent, 1F
Band: 22q11.22
Quick LinksEntrez ID:9647; OMIM: NA; Uniprot ID:PPM1F_HUMAN; ENSEMBL ID: ENSG00000100034; HGNC ID: 19388
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst4 / 6231964
fetus27 / 56401247
neonate4 / 31097128
infant0 / 236200 
juvenile3 / 5555653
adult98 / 193912150
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma8 / 8282396
colorectal tumor3 / 11424626
esophageal tumor2 / 17290115
gastrointestinal tumor4 / 11936933
germ cell tumor27 / 263845102
glioma5 / 10688346
head and neck tumor3 / 13630222
kidney tumor1 / 6895914
leukemia2 / 9584220
liver tumor3 / 9635931
lung tumor7 / 10312767
lymphoma5 / 7175569
non-neoplasia7 / 9725071
normal214 / 336030763
ovarian tumor1 / 7668213
pancreatic tumor10 / 10461695
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor4 / 12494932
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland2 / 3319760
ascites1 / 4001524
bladder0 / 297570 
blood8 / 12347864
bone4 / 7165555
bone marrow10 / 48801204
brain64 / 110098958
cervix0 / 481710 
connective tissue11 / 14925573
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus2 / 2020998
eye11 / 21105452
heart5 / 8962655
intestine10 / 23447242
kidney9 / 21177742
larynx1 / 2414541
liver9 / 20774343
lung18 / 33697453
lymph3 / 4427067
lymph node11 / 91610120
mammary gland6 / 15327139
mouth3 / 6705244
muscle12 / 107715111
nerve1 / 1576863
ovary7 / 10205168
pancreas14 / 21481265
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta25 / 28082589
prostate7 / 18934536
salivary gland0 / 201550 
skin13 / 21057461
spleen1 / 5395218
stomach1 / 9661910
testis9 / 33044227
thymus5 / 8113161
thyroid2 / 4747342
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord4 / 13680292
uterus29 / 232878124
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 37384_at
Cell line Expression level Expression bar
721_B_lymphoblasts6
Adipocyte4.75
AdrenalCortex5
Adrenalgland4
Amygdala5.15
Appendix4.85
AtrioventricularNode3.9
BDCA4+_DentriticCells10.1
Bonemarrow4.7
BronchialEpithelialCells4.8
CD105+_Endothelial4.9
CD14+_Monocytes37.45
CD19+_BCells(neg._sel.)5.25
CD33+_Myeloid42.1
CD34+21.05
CD4+_Tcells5.3
CD56+_NKCells10.6
CD71+_EarlyErythroid4.15
CD8+_Tcells4.75
CardiacMyocytes6.5
Caudatenucleus4.3
Cerebellum3.9
CerebellumPeduncles5.4
CiliaryGanglion3.3
CingulateCortex4.95
Colorectaladenocarcinoma4.8
DorsalRootGanglion4
FetalThyroid5
Fetalbrain4.95
Fetalliver4.1
Fetallung5.15
GlobusPallidus3.45
Heart7.2
Hypothalamus5.85
Kidney3.85
Leukemia_chronicMyelogenousK-56227.15
Leukemia_promyelocytic-HL-604.2
Leukemialymphoblastic(MOLT-4)3.9
Liver6.25
Lung6.25
Lymphnode4.35
Lymphoma_burkitts(Daudi)6.2
Lymphoma_burkitts(Raji)6.6
MedullaOblongata4.45
OccipitalLobe4.35
OlfactoryBulb8.9
Ovary3.2
Pancreas3.8
PancreaticIslet5.1
ParietalLobe5
Pituitary5.6
Placenta9.95
Pons4.6
PrefrontalCortex6.1
Prostate5.8
Salivarygland3.7
SkeletalMuscle6.2
Skin3.65
SmoothMuscle5.55
Spinalcord5.55
SubthalamicNucleus4.4
SuperiorCervicalGanglion6.3
TemporalLobe4.75
Testis4.2
TestisGermCell4.1
TestisIntersitial4
TestisLeydigCell4.7
TestisSeminiferousTubule4.15
Thalamus4.9
Thymus3.85
Thyroid6.15
Tongue4.65
Tonsil4.65
Trachea4.05
TrigeminalGanglion5
Uterus7.5
UterusCorpus4.9
WholeBlood26.7
Wholebrain6.95
colon4.75
pineal_day6.08
pineal_night5.84
retina5.925
small_intestine4.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P57413
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.85 ± 0.76
Basal Forebrain3.44 ± 0.59
Basal Part of Pons3.28 ± 0.88
Cerebellar Cortex3.67 ± 0.61
Cerebellar Nuclei3.29 ± 0.64
Claustrum3.86 ± 0.81
Epithalamus3.17 ± 0.65
Frontal Lobe3.43 ± 0.57
Globus Pallidus3.32 ± 0.91
Hypothalamus3.34 ± 0.6
Insula3.31 ± 0.83
Limbic Lobe3.57 ± 0.68
Mesencephalon3.46 ± 0.7
Myelencephalon3.42 ± 0.67
Occipital Lobe3.09 ± 0.65
Parietal Lobe3.39 ± 0.91
Pontine Tegmentum3.5 ± 0.74
Striatum2.92 ± 0.89
Subthalamus3.3 ± 0.57
Temporal Lobe3.61 ± 0.66
Thalamus3.17 ± 0.73
White Matter2.88 ± 0.4
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ppm1fCBCerebellum46.62
58.32
Ppm1fCTXCerebral cortex100
100
Ppm1fHIPHippocampal region87.59
100
Ppm1fHPFHippocampal formation100
100
Ppm1fHYHypothalamus76.61
71.04
Ppm1fLSXLateral septal complex89.26
66.91
Ppm1fMBMidbrain91.71
87.68
Ppm1fMYMedulla87.11
100
Ppm1fOLFOlfactory bulb100
100
Ppm1fPPons75.34
88.72
Ppm1fPALPallidum71.14
67.82
Ppm1fRHPRetrohippocampal region100
100
Ppm1fsAMYStriatum-like amygdalar nuclei96.89
77.37
Ppm1fSTRStriatum84.33
63.04
Ppm1fSTRdStriatum dorsal region77.64
57.33
Ppm1fSTRvStriatum ventral region100
77.26
Ppm1fTHThalamus61.25
57.27
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00032322 20 327 346 AIGDVFQKPYVSGEADAASR Peptide Atlas
PPM1F_HUMAN_0 0 0 0 KAPPPLAAALAHEAVSQLLQTDLSEFR PRIDE
PPM1F_HUMAN_220 13 220 232 QPELPTDPEGALR PRIDE
PPM1F_HUMAN_237 8 237 244 RTDQMFLR PRIDE
PPM1F_HUMAN_238 7 238 244 TDQMFLR PRIDE
PPM1F_HUMAN_388 10 388 397 VAEELVAAAR PRIDE
PPM1F_HUMAN_43 26 43 68 APGTVLSQEEVEGELAELAMGFLGSR PRIDE
PPM1F_HUMAN_435 19 435 453 RQDLPSSLPEPETQAPPRS PRIDE
PPM1F_HUMAN_69 27 69 95 KAPPPLAAALAHEAVSQLLQTDLSEFR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved