AutismKB 2.0

Annotation Detail for PLCH2


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Basic Information Top
Gene Symbol:PLCH2 ( PLC-eta2,PLCL4,PLCeta2 )
Gene Full Name: phospholipase C, eta 2
Band: 1p36.32
Quick LinksEntrez ID:9651; OMIM: 612836; Uniprot ID:PLCH2_HUMAN; ENSEMBL ID: ENSG00000149527; HGNC ID: 29037
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult23 / 193912111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma3 / 10688328
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal35 / 336030710
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma7 / 46356151
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain16 / 110098914
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye10 / 21105447
heart0 / 896260 
intestine3 / 23447212
kidney2 / 2117779
larynx0 / 241450 
liver0 / 2077430 
lung8 / 33697423
lymph0 / 442700 
lymph node4 / 9161043
mammary gland2 / 15327113
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206080_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.1
Adipocyte3.3
AdrenalCortex3.45
Adrenalgland2.75
Amygdala3.55
Appendix3.3
AtrioventricularNode2.5
BDCA4+_DentriticCells3.75
Bonemarrow3.25
BronchialEpithelialCells3.35
CD105+_Endothelial3.35
CD14+_Monocytes3.55
CD19+_BCells(neg._sel.)3.55
CD33+_Myeloid4.25
CD34+4.3
CD4+_Tcells3.7
CD56+_NKCells8.05
CD71+_EarlyErythroid3.05
CD8+_Tcells3.3
CardiacMyocytes4.2
Caudatenucleus2.95
Cerebellum2.7
CerebellumPeduncles5.4
CiliaryGanglion2.25
CingulateCortex6.05
Colorectaladenocarcinoma3.3
DorsalRootGanglion2.5
FetalThyroid3.15
Fetalbrain3.3
Fetalliver2.85
Fetallung2.7
GlobusPallidus2.4
Heart4.15
Hypothalamus3.7
Kidney2.75
Leukemia_chronicMyelogenousK-5623.05
Leukemia_promyelocytic-HL-602.9
Leukemialymphoblastic(MOLT-4)2.65
Liver4.25
Lung3.6
Lymphnode2.85
Lymphoma_burkitts(Daudi)4.25
Lymphoma_burkitts(Raji)4.5
MedullaOblongata3.1
OccipitalLobe3.9
OlfactoryBulb2.6
Ovary2.2
Pancreas2.65
PancreaticIslet3.5
ParietalLobe3.45
Pituitary3.85
Placenta3.4
Pons3.15
PrefrontalCortex4.25
Prostate3.85
Salivarygland2.6
SkeletalMuscle3.7
Skin2.5
SmoothMuscle3.75
Spinalcord3.55
SubthalamicNucleus2.95
SuperiorCervicalGanglion3.7
TemporalLobe3
Testis2.8
TestisGermCell2.7
TestisIntersitial2.75
TestisLeydigCell3.25
TestisSeminiferousTubule2.9
Thalamus4.6
Thymus2.6
Thyroid4.15
Tongue3.15
Tonsil3.25
Trachea3.3
TrigeminalGanglion3.2
Uterus2.7
UterusCorpus2.95
WholeBlood3.6
Wholebrain2.85
colon3.3
pineal_day56.66
pineal_night45.2
retina4.05
small_intestine3.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P372833
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.32 ± 0.88
Basal Forebrain3.14 ± 0.57
Basal Part of Pons3.21 ± 0.64
Cerebellar Cortex3.82 ± 0.4
Cerebellar Nuclei2.86 ± 0.61
Claustrum3.22 ± 0.82
Epithalamus2.41 ± 0.78
Frontal Lobe2.94 ± 0.79
Globus Pallidus3.03 ± 0.62
Hypothalamus2.77 ± 0.54
Insula3.12 ± 0.85
Limbic Lobe3.34 ± 0.82
Mesencephalon3.12 ± 0.74
Myelencephalon3.24 ± 0.77
Occipital Lobe3.54 ± 0.64
Parietal Lobe3.15 ± 0.84
Pontine Tegmentum3.13 ± 0.8
Striatum2.72 ± 0.7
Subthalamus2.68 ± 0.88
Temporal Lobe3.34 ± 0.76
Thalamus3.52 ± 0.61
White Matter3.29 ± 0.47
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Plcl4CBCerebellum97.59
100
Plcl4CTXCerebral cortex93.23
86.99
Plcl4HIPHippocampal region52.68
97.27
Plcl4HPFHippocampal formation62.95
88.15
Plcl4HYHypothalamus28.16
21.91
Plcl4LSXLateral septal complex6.58
5.49
Plcl4MBMidbrain42.47
36.85
Plcl4MYMedulla43.87
46.89
Plcl4OLFOlfactory bulb93.29
91.97
Plcl4PPons36.9
36.09
Plcl4PALPallidum18.19
15.24
Plcl4RHPRetrohippocampal region77.59
75.92
Plcl4sAMYStriatum-like amygdalar nuclei20.6
17.71
Plcl4STRStriatum30.5
22.68
Plcl4STRdStriatum dorsal region32.77
22.77
Plcl4STRvStriatum ventral region39.78
31.94
Plcl4THThalamus78.65
73.29
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00095487 18 532 549 DCEDPNNFSVSTLSPSGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018