AutismKB 2.0

Annotation Detail for TTLL4


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Basic Information Top
Gene Symbol:TTLL4 ( KIAA0173 )
Gene Full Name: tubulin tyrosine ligase-like family, member 4
Band: 2q35
Quick LinksEntrez ID:9654; OMIM: NA; Uniprot ID:TTLL4_HUMAN; ENSEMBL ID: ENSG00000135912; HGNC ID: 28976
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst5 / 6231980
fetus24 / 56401242
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult52 / 193912126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor11 / 26384541
glioma2 / 10688318
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor3 / 9635931
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal134 / 336030739
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor9 / 12494972
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood4 / 12347832
bone1 / 7165513
bone marrow2 / 4880140
brain39 / 110098935
cervix1 / 4817120
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye10 / 21105447
heart4 / 8962644
intestine8 / 23447234
kidney0 / 2117770 
larynx0 / 241450 
liver3 / 20774314
lung3 / 3369748
lymph0 / 442700 
lymph node9 / 9161098
mammary gland9 / 15327158
mouth1 / 6705214
muscle7 / 10771564
nerve1 / 1576863
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta10 / 28082535
prostate1 / 1893455
salivary gland0 / 201550 
skin13 / 21057461
spleen3 / 5395255
stomach0 / 966190 
testis35 / 330442105
thymus2 / 8113124
thyroid0 / 474730 
tonsil2 / 16999117
trachea2 / 5241338
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203702_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts22.8
Adipocyte5.55
AdrenalCortex6.25
Adrenalgland4.8
Amygdala5.95
Appendix6
AtrioventricularNode4.6
BDCA4+_DentriticCells6.45
Bonemarrow5.95
BronchialEpithelialCells5.45
CD105+_Endothelial5.8
CD14+_Monocytes9.4
CD19+_BCells(neg._sel.)5.65
CD33+_Myeloid9.45
CD34+7.15
CD4+_Tcells6.25
CD56+_NKCells6.85
CD71+_EarlyErythroid5.95
CD8+_Tcells6.1
CardiacMyocytes7.05
Caudatenucleus5.5
Cerebellum7.65
CerebellumPeduncles6.65
CiliaryGanglion3.9
CingulateCortex5.9
Colorectaladenocarcinoma5.8
DorsalRootGanglion5.9
FetalThyroid5.35
Fetalbrain5.7
Fetalliver5.1
Fetallung4.65
GlobusPallidus4.25
Heart7.35
Hypothalamus6.45
Kidney4.8
Leukemia_chronicMyelogenousK-5626
Leukemia_promyelocytic-HL-605.15
Leukemialymphoblastic(MOLT-4)4.65
Liver7.7
Lung6
Lymphnode4.75
Lymphoma_burkitts(Daudi)10.55
Lymphoma_burkitts(Raji)7.95
MedullaOblongata5.15
OccipitalLobe5.25
OlfactoryBulb5.9
Ovary3.85
Pancreas4.65
PancreaticIslet6.15
ParietalLobe7.2
Pituitary7.2
Placenta6.5
Pons5.35
PrefrontalCortex7.1
Prostate6.25
Salivarygland4.7
SkeletalMuscle7.25
Skin4.55
SmoothMuscle5.55
Spinalcord8.8
SubthalamicNucleus5.2
SuperiorCervicalGanglion6.8
TemporalLobe5.2
Testis36.4
TestisGermCell6.9
TestisIntersitial8.4
TestisLeydigCell7
TestisSeminiferousTubule6.9
Thalamus5.9
Thymus5
Thyroid6.8
Tongue5.7
Tonsil5.55
Trachea4.85
TrigeminalGanglion5.85
Uterus4.5
UterusCorpus5.3
WholeBlood7.6
Wholebrain4.65
colon5.65
pineal_day7.12
pineal_night6.98
retina11.625
small_intestine5.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8706_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.31 ± 0.98
Basal Forebrain2.97 ± 0.51
Basal Part of Pons2.91 ± 0.7
Cerebellar Cortex2.75 ± 0.49
Cerebellar Nuclei3.13 ± 0.73
Claustrum3.28 ± 0.76
Epithalamus3.62 ± 0.67
Frontal Lobe2.79 ± 0.75
Globus Pallidus3.83 ± 0.43
Hypothalamus3.24 ± 0.44
Insula2.61 ± 0.53
Limbic Lobe2.86 ± 0.69
Mesencephalon3.26 ± 0.69
Myelencephalon3.05 ± 0.69
Occipital Lobe3.38 ± 0.66
Parietal Lobe3.12 ± 0.7
Pontine Tegmentum3.26 ± 0.71
Striatum3.91 ± 0.75
Subthalamus3.41 ± 0.68
Temporal Lobe2.97 ± 0.72
Thalamus3.25 ± 0.59
White Matter4.32 ± 0.68
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ttll4CBCerebellum10.24
10.23
Ttll4CTXCerebral cortex1.04
1.38
Ttll4HIPHippocampal region3.8
3.95
Ttll4HPFHippocampal formation2.61
2.44
Ttll4HYHypothalamus0.14
0.13
Ttll4LSXLateral septal complex0.28
0.4
Ttll4MBMidbrain0.56
0.74
Ttll4MYMedulla1
1.02
Ttll4OLFOlfactory bulb1.94
2.95
Ttll4PPons0.45
0.47
Ttll4PALPallidum0.17
0.18
Ttll4RHPRetrohippocampal region1.15
0.85
Ttll4sAMYStriatum-like amygdalar nuclei0.08
0.05
Ttll4STRStriatum0.28
0.38
Ttll4STRdStriatum dorsal region0.22
0.38
Ttll4STRvStriatum ventral region0.57
0.55
Ttll4THThalamus0.33
0.3
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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