AutismKB 2.0

Annotation Detail for KIAA0430


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Basic Information Top
Gene Symbol:KIAA0430 ( LKAP )
Gene Full Name: KIAA0430
Band: 16p13.11
Quick LinksEntrez ID:9665; OMIM: NA; Uniprot ID:LKAP_HUMAN; ENSEMBL ID: ENSG00000166783; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst3 / 6231948
fetus29 / 56401251
neonate1 / 3109732
infant2 / 2362084
juvenile2 / 5555635
adult127 / 193912165
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor9 / 9417895
cervical tumor1 / 3436629
chondrosarcoma5 / 8282360
colorectal tumor8 / 11424670
esophageal tumor0 / 172900 
gastrointestinal tumor10 / 11936983
germ cell tumor15 / 26384556
glioma3 / 10688328
head and neck tumor20 / 136302146
kidney tumor1 / 6895914
leukemia6 / 9584262
liver tumor5 / 9635951
lung tumor1 / 1031279
lymphoma6 / 7175583
non-neoplasia7 / 9725071
normal206 / 336030761
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer11 / 102680107
retinoblastoma3 / 4635664
skin tumor4 / 12494932
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland2 / 3319760
ascites2 / 4001549
bladder1 / 2975733
blood12 / 12347897
bone4 / 7165555
bone marrow3 / 4880161
brain75 / 110098968
cervix1 / 4817120
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye12 / 21105456
heart7 / 8962678
intestine11 / 23447246
kidney5 / 21177723
larynx10 / 24145414
liver10 / 20774348
lung17 / 33697450
lymph3 / 4427067
lymph node16 / 91610174
mammary gland13 / 15327184
mouth7 / 67052104
muscle13 / 107715120
nerve2 / 15768126
ovary3 / 10205129
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland2 / 16585120
placenta8 / 28082528
prostate13 / 18934568
salivary gland0 / 201550 
skin9 / 21057442
spleen1 / 5395218
stomach10 / 96619103
testis10 / 33044230
thymus6 / 8113173
thyroid4 / 4747384
tonsil5 / 16999294
trachea2 / 5241338
umbilical cord0 / 136800 
uterus17 / 23287872
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202386_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts135.95
Adipocyte21.4
AdrenalCortex16.8
Adrenalgland25.4
Amygdala144.5
Appendix15.95
AtrioventricularNode11
BDCA4+_DentriticCells313.2
Bonemarrow95.3
BronchialEpithelialCells44.95
CD105+_Endothelial86.95
CD14+_Monocytes238.7
CD19+_BCells(neg._sel.)530.6
CD33+_Myeloid392.15
CD34+187.75
CD4+_Tcells521.5
CD56+_NKCells294.55
CD71+_EarlyErythroid603.7
CD8+_Tcells488.35
CardiacMyocytes50.15
Caudatenucleus30.75
Cerebellum44.7
CerebellumPeduncles51.95
CiliaryGanglion9.25
CingulateCortex90.75
Colorectaladenocarcinoma13.8
DorsalRootGanglion17.2
FetalThyroid72.7
Fetalbrain47.9
Fetalliver32.35
Fetallung50.3
GlobusPallidus68.05
Heart17.4
Hypothalamus272.95
Kidney22.3
Leukemia_chronicMyelogenousK-56216.3
Leukemia_promyelocytic-HL-6025.5
Leukemialymphoblastic(MOLT-4)23.65
Liver20.8
Lung44.45
Lymphnode177.35
Lymphoma_burkitts(Daudi)54.95
Lymphoma_burkitts(Raji)70.2
MedullaOblongata60.15
OccipitalLobe105.7
OlfactoryBulb86.85
Ovary8.5
Pancreas24.45
PancreaticIslet53.8
ParietalLobe69.05
Pituitary61.45
Placenta46.4
Pons33.5
PrefrontalCortex249.2
Prostate108.15
Salivarygland45.95
SkeletalMuscle18.5
Skin9.3
SmoothMuscle48.05
Spinalcord61.75
SubthalamicNucleus81.85
SuperiorCervicalGanglion13.2
TemporalLobe45.45
Testis19.25
TestisGermCell48
TestisIntersitial19.25
TestisLeydigCell21.5
TestisSeminiferousTubule17.55
Thalamus117.1
Thymus82
Thyroid177.25
Tongue14
Tonsil91.8
Trachea33.95
TrigeminalGanglion16.75
Uterus142.4
UterusCorpus19.1
WholeBlood252.2
Wholebrain95.7
colon39.05
pineal_day136.9
pineal_night129.56
retina118.25
small_intestine28
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5396_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.93 ± 0.24
Basal Forebrain8.15 ± 0.16
Basal Part of Pons8.32 ± 0.17
Cerebellar Cortex7.96 ± 0.17
Cerebellar Nuclei8.28 ± 0.16
Claustrum8.43 ± 0.21
Epithalamus7.95 ± 0.41
Frontal Lobe8.15 ± 0.29
Globus Pallidus8.02 ± 0.22
Hypothalamus8.39 ± 0.21
Insula8.03 ± 0.26
Limbic Lobe8.01 ± 0.23
Mesencephalon8.28 ± 0.22
Myelencephalon8.13 ± 0.24
Occipital Lobe8.26 ± 0.17
Parietal Lobe8.35 ± 0.22
Pontine Tegmentum8.13 ± 0.25
Striatum7.93 ± 0.22
Subthalamus8.59 ± 0.19
Temporal Lobe8.09 ± 0.27
Thalamus8.2 ± 0.24
White Matter7.84 ± 0.43
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
4921513D23RikCBCerebellum19.51
22.87
4921513D23RikCTXCerebral cortex47.02
33.01
4921513D23RikHIPHippocampal region23.46
22.14
4921513D23RikHPFHippocampal formation32.61
27.11
4921513D23RikHYHypothalamus35.78
25.58
4921513D23RikLSXLateral septal complex20.52
13.04
4921513D23RikMBMidbrain26.64
22.37
4921513D23RikMYMedulla47.35
43.88
4921513D23RikOLFOlfactory bulb58.61
44.21
4921513D23RikPPons43.35
39.15
4921513D23RikPALPallidum36.59
28.15
4921513D23RikRHPRetrohippocampal region50.97
36.18
4921513D23RiksAMYStriatum-like amygdalar nuclei48.76
32.04
4921513D23RikSTRStriatum31.78
20.79
4921513D23RikSTRdStriatum dorsal region25.82
17.22
4921513D23RikSTRvStriatum ventral region46.36
28.24
4921513D23RikTHThalamus40.48
30.91
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00025820 25 1440 1464 HYESTHNTPLNPCEYGFMTLTELLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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