Annotation Detail for KDM4A
Basic Information Top
| Gene Symbol: | KDM4A ( JHDM3A,JMJD2,JMJD2A,KIAA0677 ) |
|---|---|
| Gene Full Name: | lysine (K)-specific demethylase 4A |
| Band: | 1p34.2-p34.1 |
| Quick Links | Entrez ID:9682; OMIM: 609764; Uniprot ID:KDM4A_HUMAN; ENSEMBL ID: ENSG00000066135; HGNC ID: 22978 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.155983
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 7 / 70761 | 98 |  |
| blastocyst | 2 / 62319 | 32 |  |
| fetus | 24 / 564012 | 42 | |
| neonate | 1 / 31097 | 32 | |
| infant | 3 / 23620 | 127 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 66 / 1939121 | 34 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 1 / 17475 | 57 | |
| breast (mammary gland) tumor | 6 / 94178 | 63 | |
| cervical tumor | 1 / 34366 | 29 | |
| chondrosarcoma | 1 / 82823 | 12 | |
| colorectal tumor | 6 / 114246 | 52 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 3 / 119369 | 25 | |
| germ cell tumor | 7 / 263845 | 26 | |
| glioma | 4 / 106883 | 37 | |
| head and neck tumor | 6 / 136302 | 44 | |
| kidney tumor | 7 / 68959 | 101 | |
| leukemia | 0 / 95842 | 0 | |
| liver tumor | 3 / 96359 | 31 | |
| lung tumor | 8 / 103127 | 77 | |
| lymphoma | 1 / 71755 | 13 | |
| non-neoplasia | 4 / 97250 | 41 | |
| normal | 108 / 3360307 | 32 | |
| ovarian tumor | 1 / 76682 | 13 | |
| pancreatic tumor | 3 / 104616 | 28 | |
| primitive neuroectodermal tumor of the CNS | 4 / 125680 | 31 | |
| prostate cancer | 5 / 102680 | 48 | |
| retinoblastoma | 3 / 46356 | 64 | |
| skin tumor | 2 / 124949 | 16 | |
| soft tissue/muscle tissue tumor | 13 / 125191 | 103 | |
| uterine tumor | 7 / 90257 | 77 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 1 / 13106 | 76 | |
| adrenal gland | 2 / 33197 | 60 | |
| ascites | 3 / 40015 | 74 | |
| bladder | 1 / 29757 | 33 | |
| blood | 8 / 123478 | 64 | |
| bone | 0 / 71655 | 0 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 17 / 1100989 | 15 | |
| cervix | 1 / 48171 | 20 | |
| connective tissue | 4 / 149255 | 26 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 16 / 215722 | 74 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 10 / 211054 | 47 | |
| heart | 2 / 89626 | 22 | |
| intestine | 9 / 234472 | 38 | |
| kidney | 10 / 211777 | 47 | |
| larynx | 0 / 24145 | 0 | |
| liver | 6 / 207743 | 28 | |
| lung | 15 / 336974 | 44 | |
| lymph | 1 / 44270 | 22 | |
| lymph node | 6 / 91610 | 65 | |
| mammary gland | 10 / 153271 | 65 | |
| mouth | 1 / 67052 | 14 | |
| muscle | 4 / 107715 | 37 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 1 / 102051 | 9 |  |
| pancreas | 7 / 214812 | 32 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 7 / 280825 | 24 | |
| prostate | 13 / 189345 | 68 | |
| salivary gland | 3 / 20155 | 148 | |
| skin | 3 / 210574 | 14 | |
| spleen | 2 / 53952 | 37 | |
| stomach | 0 / 96619 | 0 | |
| testis | 3 / 330442 | 9 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 4 / 47473 | 84 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 1 / 13680 | 73 | |
| uterus | 19 / 232878 | 81 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 203205_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 55.95 | |
| Adipocyte | 44.8 | |
| AdrenalCortex | 86.85 | |
| Adrenalgland | 51.65 | |
| Amygdala | 36.05 | |
| Appendix | 121.75 | |
| AtrioventricularNode | 63.25 | |
| BDCA4+_DentriticCells | 85.5 | |
| Bonemarrow | 47.75 | |
| BronchialEpithelialCells | 44.55 | |
| CD105+_Endothelial | 90 | |
| CD14+_Monocytes | 56.65 | |
| CD19+_BCells(neg._sel.) | 61.5 | |
| CD33+_Myeloid | 95.75 | |
| CD34+ | 93.6 | |
| CD4+_Tcells | 55.45 | |
| CD56+_NKCells | 94.8 | |
| CD71+_EarlyErythroid | 42.6 | |
| CD8+_Tcells | 46.8 | |
| CardiacMyocytes | 59.3 | |
| Caudatenucleus | 42 | |
| Cerebellum | 52.8 | |
| CerebellumPeduncles | 55.45 | |
| CiliaryGanglion | 37.1 | |
| CingulateCortex | 61.45 | |
| Colorectaladenocarcinoma | 45.15 | |
| DorsalRootGanglion | 62.35 | |
| FetalThyroid | 44.35 | |
| Fetalbrain | 50.15 | |
| Fetalliver | 42.85 | |
| Fetallung | 43.95 | |
| GlobusPallidus | 39.25 | |
| Heart | 66.7 | |
| Hypothalamus | 51.95 | |
| Kidney | 49.4 | |
| Leukemia_chronicMyelogenousK-562 | 44.1 | |
| Leukemia_promyelocytic-HL-60 | 70.9 | |
| Leukemialymphoblastic(MOLT-4) | 58.95 | |
| Liver | 58.45 | |
| Lung | 51.7 | |
| Lymphnode | 44.05 | |
| Lymphoma_burkitts(Daudi) | 70.3 | |
| Lymphoma_burkitts(Raji) | 95.1 | |
| MedullaOblongata | 45.9 | |
| OccipitalLobe | 36.45 | |
| OlfactoryBulb | 38.95 | |
| Ovary | 44.9 | |
| Pancreas | 46.65 | |
| PancreaticIslet | 52.8 | |
| ParietalLobe | 52.2 | |
| Pituitary | 59.85 | |
| Placenta | 43.2 | |
| Pons | 64.1 | |
| PrefrontalCortex | 60.5 | |
| Prostate | 62 | |
| Salivarygland | 37.9 | |
| SkeletalMuscle | 54.15 | |
| Skin | 61.15 | |
| SmoothMuscle | 53.25 | |
| Spinalcord | 50.9 | |
| SubthalamicNucleus | 43.75 | |
| SuperiorCervicalGanglion | 78.35 | |
| TemporalLobe | 44.55 | |
| Testis | 37.2 | |
| TestisGermCell | 42.35 | |
| TestisIntersitial | 38.1 | |
| TestisLeydigCell | 42.9 | |
| TestisSeminiferousTubule | 39.25 | |
| Thalamus | 48.65 | |
| Thymus | 49.75 | |
| Thyroid | 57.65 | |
| Tongue | 52.45 | |
| Tonsil | 58.7 | |
| Trachea | 38.8 | |
| TrigeminalGanglion | 46.4 | |
| Uterus | 46.5 | |
| UterusCorpus | 48.25 | |
| WholeBlood | 53.7 | |
| Wholebrain | 37.6 | |
| colon | 43 | |
| pineal_day | 71.6 | |
| pineal_night | 63.34 | |
| retina | 49.825 | |
| small_intestine | 46.25 | |
- Probe name: CUST_14122_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 6.28 ± 0.4 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 6.4 ± 0.26 | |
| Basal Part of Pons | 6.79 ± 0.19 | |
| Cerebellar Cortex | 6.74 ± 0.25 | |
| Cerebellar Nuclei | 6.2 ± 0.63 | |
| Claustrum | 6 ± 0.63 | |
| Epithalamus | 6.55 ± 0.48 | |
| Frontal Lobe | 6.5 ± 0.32 | |
| Globus Pallidus | 6.2 ± 0.29 | |
| Hypothalamus | 6.33 ± 0.26 | |
| Insula | 6.49 ± 0.19 | |
| Limbic Lobe | 6.42 ± 0.38 | |
| Mesencephalon | 6.36 ± 0.36 | |
| Myelencephalon | 6.4 ± 0.38 | |
| Occipital Lobe | 6.25 ± 0.35 | |
| Parietal Lobe | 6.49 ± 0.33 | |
| Pontine Tegmentum | 6.36 ± 0.35 | |
| Striatum | 6.37 ± 0.32 | |
| Subthalamus | 6.3 ± 0.48 | |
| Temporal Lobe | 6.53 ± 0.28 | |
| Thalamus | 6.42 ± 0.33 | |
| White Matter | 6.76 ± 0.26 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Jmjd2a | CB | Cerebellum | 95.27 | |
| 100 | | |||
| Jmjd2a | CTX | Cerebral cortex | 100 | |
| 100 | | |||
| Jmjd2a | HIP | Hippocampal region | 100 | |
| 100 | | |||
| Jmjd2a | HPF | Hippocampal formation | 100 | |
| 100 | | |||
| Jmjd2a | HY | Hypothalamus | 71.34 | |
| 65.59 | | |||
| Jmjd2a | LSX | Lateral septal complex | 100 | |
| 98.22 | | |||
| Jmjd2a | MB | Midbrain | 79.99 | |
| 82.63 | | |||
| Jmjd2a | MY | Medulla | 76.58 | |
| 90.07 | | |||
| Jmjd2a | OLF | Olfactory bulb | 100 | |
| 100 | | |||
| Jmjd2a | P | Pons | 63.11 | |
| 70 | | |||
| Jmjd2a | PAL | Pallidum | 75.94 | |
| 81.19 | | |||
| Jmjd2a | RHP | Retrohippocampal region | 100 | |
| 100 | | |||
| Jmjd2a | sAMY | Striatum-like amygdalar nuclei | 100 | |
| 100 | | |||
| Jmjd2a | STR | Striatum | 100 | |
| 100 | | |||
| Jmjd2a | STRd | Striatum dorsal region | 100 | |
| 98.1 | | |||
| Jmjd2a | STRv | Striatum ventral region | 100 | |
| 100 | | |||
| Jmjd2a | TH | Thalamus | 89.35 | |
| 93.45 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| KDM4A_HUMAN_2 | 12 | 2 | 13 | ASESETLNPSAR | PRIDE |