AutismKB 2.0

Annotation Detail for LRRC14


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Basic Information Top
Gene Symbol:LRRC14 ( KIAA0014,LRRC14A )
Gene Full Name: leucine rich repeat containing 14
Band: 8q24.3
Quick LinksEntrez ID:9684; OMIM: NA; Uniprot ID:LRC14_HUMAN; ENSEMBL ID: ENSG00000160959; HGNC ID: 20419
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst2 / 6231932
fetus10 / 56401217
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult59 / 193912130
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor4 / 9417842
cervical tumor1 / 3436629
chondrosarcoma6 / 8282372
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor5 / 26384518
glioma6 / 10688356
head and neck tumor1 / 1363027
kidney tumor2 / 6895929
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor4 / 10312738
lymphoma7 / 7175597
non-neoplasia0 / 972500 
normal74 / 336030722
ovarian tumor5 / 7668265
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor5 / 12494940
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder1 / 2975733
blood0 / 1234780 
bone4 / 7165555
bone marrow1 / 4880120
brain23 / 110098920
cervix1 / 4817120
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye7 / 21105433
heart0 / 896260 
intestine6 / 23447225
kidney5 / 21177723
larynx0 / 241450 
liver0 / 2077430 
lung10 / 33697429
lymph2 / 4427045
lymph node3 / 9161032
mammary gland4 / 15327126
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary7 / 10205168
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta8 / 28082528
prostate5 / 18934526
salivary gland0 / 201550 
skin17 / 21057480
spleen0 / 539520 
stomach0 / 966190 
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus12 / 23287851
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 32062_at
Cell line Expression level Expression bar
721_B_lymphoblasts12.3
Adipocyte10.2
AdrenalCortex11.1
Adrenalgland8.7
Amygdala10.5
Appendix10.3
AtrioventricularNode7.9
BDCA4+_DentriticCells11.35
Bonemarrow10.2
BronchialEpithelialCells10.15
CD105+_Endothelial11.15
CD14+_Monocytes10.9
CD19+_BCells(neg._sel.)16
CD33+_Myeloid12.95
CD34+14.3
CD4+_Tcells11.25
CD56+_NKCells12.55
CD71+_EarlyErythroid9.7
CD8+_Tcells11.2
CardiacMyocytes13.3
Caudatenucleus9.25
Cerebellum8.25
CerebellumPeduncles11.9
CiliaryGanglion7.3
CingulateCortex10.95
Colorectaladenocarcinoma9.95
DorsalRootGanglion7.9
FetalThyroid11.9
Fetalbrain10.2
Fetalliver8.95
Fetallung8.4
GlobusPallidus7.65
Heart18.55
Hypothalamus11.25
Kidney8.6
Leukemia_chronicMyelogenousK-56212.15
Leukemia_promyelocytic-HL-6010.85
Leukemialymphoblastic(MOLT-4)10.35
Liver14.15
Lung11.55
Lymphnode9.1
Lymphoma_burkitts(Daudi)14
Lymphoma_burkitts(Raji)14.6
MedullaOblongata9.35
OccipitalLobe9.15
OlfactoryBulb8.15
Ovary6.85
Pancreas8.3
PancreaticIslet10.75
ParietalLobe11
Pituitary11.85
Placenta9.35
Pons9.8
PrefrontalCortex12.85
Prostate11.95
Salivarygland8.2
SkeletalMuscle12
Skin8
SmoothMuscle11.6
Spinalcord11.5
SubthalamicNucleus10.05
SuperiorCervicalGanglion12
TemporalLobe9.45
Testis9.1
TestisGermCell9.45
TestisIntersitial8.8
TestisLeydigCell10.15
TestisSeminiferousTubule8.8
Thalamus10.75
Thymus8.25
Thyroid11.5
Tongue10.6
Tonsil9.85
Trachea8.1
TrigeminalGanglion10.4
Uterus7.45
UterusCorpus9.2
WholeBlood11.3
Wholebrain8.7
colon9.4
pineal_day12.32
pineal_night11.7
retina11.5
small_intestine8.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P134946
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.97 ± 0.6
Basal Forebrain7.05 ± 0.27
Basal Part of Pons7.68 ± 0.31
Cerebellar Cortex6.85 ± 0.16
Cerebellar Nuclei6.88 ± 0.69
Claustrum7.24 ± 0.4
Epithalamus6.7 ± 0.39
Frontal Lobe7.42 ± 0.34
Globus Pallidus6.21 ± 0.59
Hypothalamus7 ± 0.31
Insula7.29 ± 0.18
Limbic Lobe7.32 ± 0.42
Mesencephalon7.09 ± 0.45
Myelencephalon7.12 ± 0.51
Occipital Lobe6.72 ± 0.6
Parietal Lobe7.36 ± 0.44
Pontine Tegmentum6.99 ± 0.34
Striatum6.75 ± 0.67
Subthalamus7.25 ± 0.3
Temporal Lobe7.32 ± 0.31
Thalamus6.87 ± 0.33
White Matter5.84 ± 0.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lrrc14CBCerebellum2.95
3.43
Lrrc14CTXCerebral cortex6.71
4.25
Lrrc14HIPHippocampal region3.14
2.52
Lrrc14HPFHippocampal formation5.07
3.66
Lrrc14HYHypothalamus1.48
1.02
Lrrc14LSXLateral septal complex0.94
0.68
Lrrc14MBMidbrain2.95
3.14
Lrrc14MYMedulla10.01
9.83
Lrrc14OLFOlfactory bulb10.06
6.32
Lrrc14PPons4.55
4.31
Lrrc14PALPallidum5.27
4.37
Lrrc14RHPRetrohippocampal region8.87
5.63
Lrrc14sAMYStriatum-like amygdalar nuclei2.31
1.48
Lrrc14STRStriatum2.52
1.61
Lrrc14STRdStriatum dorsal region2.75
1.8
Lrrc14STRvStriatum ventral region3.02
1.72
Lrrc14THThalamus3.82
2.58
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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