AutismKB 2.0

Annotation Detail for CROCC


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Basic Information Top
Gene Symbol:CROCC ( KIAA0445,ROLT )
Gene Full Name: ciliary rootlet coiled-coil, rootletin
Band: 1p36.13
Quick LinksEntrez ID:9696; OMIM: NA; Uniprot ID:CROCC_HUMAN; ENSEMBL ID: ENSG00000058453; HGNC ID: 21299
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst5 / 6231980
fetus15 / 56401226
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult24 / 193912112
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma5 / 8282360
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor1 / 2638453
glioma3 / 10688328
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal52 / 336030715
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer1 / 1026809
retinoblastoma2 / 4635643
skin tumor4 / 12494932
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone4 / 7165555
bone marrow0 / 488010 
brain21 / 110098919
cervix1 / 4817120
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus0 / 202090 
eye6 / 21105428
heart0 / 896260 
intestine2 / 2344728
kidney1 / 2117774
larynx0 / 241450 
liver1 / 2077434
lung5 / 33697414
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth1 / 6705214
muscle0 / 1077150 
nerve1 / 1576863
ovary1 / 1020519
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate1 / 1893455
salivary gland0 / 201550 
skin4 / 21057418
spleen0 / 539520 
stomach0 / 966190 
testis3 / 3304429
thymus1 / 8113112
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206274_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.1
Adipocyte9.7
AdrenalCortex11.45
Adrenalgland8.65
Amygdala10.65
Appendix10.75
AtrioventricularNode12.8
BDCA4+_DentriticCells9.75
Bonemarrow10.25
BronchialEpithelialCells8.95
CD105+_Endothelial9.2
CD14+_Monocytes9.95
CD19+_BCells(neg._sel.)10.5
CD33+_Myeloid12.35
CD34+13
CD4+_Tcells12.85
CD56+_NKCells15.65
CD71+_EarlyErythroid9.1
CD8+_Tcells10.05
CardiacMyocytes13.5
Caudatenucleus10.3
Cerebellum8.35
CerebellumPeduncles14.25
CiliaryGanglion7.4
CingulateCortex10.4
Colorectaladenocarcinoma10.05
DorsalRootGanglion8.95
FetalThyroid11.15
Fetalbrain13.55
Fetalliver8.4
Fetallung8.65
GlobusPallidus7.6
Heart14.3
Hypothalamus12.1
Kidney8.45
Leukemia_chronicMyelogenousK-5628.75
Leukemia_promyelocytic-HL-608.5
Leukemialymphoblastic(MOLT-4)8.35
Liver13.35
Lung11.3
Lymphnode8.6
Lymphoma_burkitts(Daudi)13.15
Lymphoma_burkitts(Raji)14.5
MedullaOblongata9.1
OccipitalLobe8.95
OlfactoryBulb9.8
Ovary6.7
Pancreas10.4
PancreaticIslet10.75
ParietalLobe10.85
Pituitary11.9
Placenta8.9
Pons14.4
PrefrontalCortex11.7
Prostate12.05
Salivarygland8
SkeletalMuscle13.95
Skin8.15
SmoothMuscle11.25
Spinalcord10.8
SubthalamicNucleus9.2
SuperiorCervicalGanglion12.55
TemporalLobe10
Testis8.45
TestisGermCell8.45
TestisIntersitial8.45
TestisLeydigCell11.1
TestisSeminiferousTubule8.5
Thalamus10.3
Thymus12.2
Thyroid12
Tongue10.3
Tonsil10.15
Trachea8.35
TrigeminalGanglion18.25
Uterus8.25
UterusCorpus9.8
WholeBlood10.4
Wholebrain8.1
colon9.9
pineal_day12.26
pineal_night11.96
retina13.7
small_intestine9.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P149546
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.39 ± 1.14
Basal Forebrain2.88 ± 0.39
Basal Part of Pons2.74 ± 0.77
Cerebellar Cortex3.75 ± 0.43
Cerebellar Nuclei2.95 ± 0.63
Claustrum3.37 ± 0.87
Epithalamus3 ± 0.54
Frontal Lobe2.71 ± 0.78
Globus Pallidus2.79 ± 0.78
Hypothalamus2.68 ± 0.43
Insula2.88 ± 0.79
Limbic Lobe3.05 ± 0.87
Mesencephalon3 ± 0.73
Myelencephalon3 ± 0.7
Occipital Lobe3.41 ± 0.57
Parietal Lobe3.05 ± 0.76
Pontine Tegmentum3.03 ± 0.83
Striatum2.73 ± 0.85
Subthalamus2.98 ± 1.01
Temporal Lobe3.02 ± 0.73
Thalamus2.73 ± 0.65
White Matter2.96 ± 0.46
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
CroccCBCerebellum85.49
100
CroccCTXCerebral cortex100
100
CroccHIPHippocampal region100
100
CroccHPFHippocampal formation100
100
CroccHYHypothalamus100
100
CroccLSXLateral septal complex100
100
CroccMBMidbrain100
100
CroccMYMedulla84.62
96.63
CroccOLFOlfactory bulb100
100
CroccPPons84.99
88.21
CroccPALPallidum98.61
92.91
CroccRHPRetrohippocampal region100
100
CroccsAMYStriatum-like amygdalar nuclei100
100
CroccSTRStriatum100
100
CroccSTRdStriatum dorsal region100
100
CroccSTRvStriatum ventral region100
100
CroccTHThalamus80.96
82.81
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CROCC_HUMAN_627 11 627 637 EKLQAAQEELR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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