AutismKB 2.0

Annotation Detail for RIMS2


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Basic Information Top
Gene Symbol:RIMS2 ( DKFZp781A0653,KIAA0751,OBOE,RAB3IP3,RIM2 )
Gene Full Name: regulating synaptic membrane exocytosis 2
Band: 8q22.3
Quick LinksEntrez ID:9699; OMIM: 606630; Uniprot ID:RIMS2_HUMAN; ENSEMBL ID: ENSG00000176406; HGNC ID: 17283
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst1 / 6231916
fetus10 / 56401217
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult22 / 193912111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal84 / 336030724
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain53 / 110098948
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye9 / 21105442
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland7 / 16585422
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach0 / 966190 
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206137_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.7
Adipocyte11.3
AdrenalCortex50.15
Adrenalgland56.85
Amygdala48.9
Appendix11.3
AtrioventricularNode8.25
BDCA4+_DentriticCells10.65
Bonemarrow11.1
BronchialEpithelialCells11.5
CD105+_Endothelial6.7
CD14+_Monocytes11.15
CD19+_BCells(neg._sel.)8.7
CD33+_Myeloid13
CD34+6.95
CD4+_Tcells9.65
CD56+_NKCells8.3
CD71+_EarlyErythroid9.75
CD8+_Tcells7.8
CardiacMyocytes15.05
Caudatenucleus24.05
Cerebellum12.6
CerebellumPeduncles14.45
CiliaryGanglion7.8
CingulateCortex50.7
Colorectaladenocarcinoma11.5
DorsalRootGanglion8.5
FetalThyroid11.5
Fetalbrain19.3
Fetalliver9.85
Fetallung9.35
GlobusPallidus14.3
Heart14.85
Hypothalamus25.25
Kidney9.1
Leukemia_chronicMyelogenousK-56210.5
Leukemia_promyelocytic-HL-6010.1
Leukemialymphoblastic(MOLT-4)9.15
Liver14.85
Lung12.3
Lymphnode9.9
Lymphoma_burkitts(Daudi)16.2
Lymphoma_burkitts(Raji)15.7
MedullaOblongata42.4
OccipitalLobe56.3
OlfactoryBulb8.8
Ovary7.45
Pancreas9.15
PancreaticIslet13.15
ParietalLobe27.75
Pituitary36.85
Placenta12
Pons25
PrefrontalCortex91.1
Prostate13.7
Salivarygland7.75
SkeletalMuscle9.4
Skin8.5
SmoothMuscle13.2
Spinalcord12.05
SubthalamicNucleus44.35
SuperiorCervicalGanglion12.55
TemporalLobe42.05
Testis10.05
TestisGermCell9.4
TestisIntersitial9.65
TestisLeydigCell11.1
TestisSeminiferousTubule9.85
Thalamus35.95
Thymus10
Thyroid13.85
Tongue11.55
Tonsil10.95
Trachea9.15
TrigeminalGanglion10.7
Uterus9.4
UterusCorpus10.15
WholeBlood12.05
Wholebrain28.7
colon11.2
pineal_day58.78
pineal_night38.24
retina17.05
small_intestine11
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_38_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.81 ± 0.4
Basal Forebrain10.68 ± 0.18
Basal Part of Pons10.57 ± 0.27
Cerebellar Cortex10.6 ± 0.23
Cerebellar Nuclei9.18 ± 0.36
Claustrum11.25 ± 0.31
Epithalamus9.41 ± 0.93
Frontal Lobe10.06 ± 0.43
Globus Pallidus9.09 ± 0.49
Hypothalamus10.38 ± 0.64
Insula10.28 ± 0.32
Limbic Lobe10.11 ± 0.37
Mesencephalon10.18 ± 0.55
Myelencephalon10.25 ± 0.55
Occipital Lobe10.64 ± 0.53
Parietal Lobe10.42 ± 0.39
Pontine Tegmentum10.07 ± 0.51
Striatum10.63 ± 0.46
Subthalamus9.57 ± 0.09
Temporal Lobe10.26 ± 0.39
Thalamus10.6 ± 0.28
White Matter8.07 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rims2CBCerebellum100
100
Rims2CTXCerebral cortex100
91.75
Rims2HIPHippocampal region37.61
37.06
Rims2HPFHippocampal formation59.75
53.09
Rims2HYHypothalamus48.09
35.34
Rims2LSXLateral septal complex71.42
50.99
Rims2MBMidbrain56.75
45.64
Rims2MYMedulla59.11
52.21
Rims2OLFOlfactory bulb93.58
79.57
Rims2PPons48.78
40.91
Rims2PALPallidum54.24
43.94
Rims2RHPRetrohippocampal region98.86
77.15
Rims2sAMYStriatum-like amygdalar nuclei100
73.98
Rims2STRStriatum94.43
68.35
Rims2STRdStriatum dorsal region88.03
62.15
Rims2STRvStriatum ventral region100
85
Rims2THThalamus100
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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