AutismKB 2.0

Annotation Detail for KIAA0226


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Basic Information Top
Gene Symbol:KIAA0226 ( RUBICON )
Gene Full Name: KIAA0226
Band: 3q29
Quick LinksEntrez ID:9711; OMIM: 613516; Uniprot ID:RUBIC_HUMAN; ENSEMBL ID: ENSG00000145016; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus24 / 56401242
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult54 / 193912127
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor3 / 11424626
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor7 / 26384526
glioma3 / 10688328
head and neck tumor6 / 13630244
kidney tumor2 / 6895929
leukemia1 / 9584210
liver tumor4 / 9635941
lung tumor2 / 10312719
lymphoma2 / 7175527
non-neoplasia4 / 9725041
normal132 / 336030739
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood4 / 12347832
bone1 / 7165513
bone marrow0 / 488010 
brain39 / 110098935
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus1 / 2020949
eye7 / 21105433
heart5 / 8962655
intestine5 / 23447221
kidney6 / 21177728
larynx2 / 2414582
liver4 / 20774319
lung15 / 33697444
lymph1 / 4427022
lymph node23 / 91610251
mammary gland5 / 15327132
mouth2 / 6705229
muscle3 / 10771527
nerve0 / 157680 
ovary1 / 1020519
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta6 / 28082521
prostate3 / 18934515
salivary gland0 / 201550 
skin8 / 21057437
spleen3 / 5395255
stomach1 / 9661910
testis15 / 33044245
thymus4 / 8113149
thyroid2 / 4747342
tonsil1 / 1699958
trachea2 / 5241338
umbilical cord0 / 136800 
uterus5 / 23287821
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212733_at
Cell line Expression level Expression bar
721_B_lymphoblasts48.75
Adipocyte11.55
AdrenalCortex20.05
Adrenalgland14.8
Amygdala35.85
Appendix16.1
AtrioventricularNode12.5
BDCA4+_DentriticCells384.95
Bonemarrow16.7
BronchialEpithelialCells18.5
CD105+_Endothelial20.5
CD14+_Monocytes94.75
CD19+_BCells(neg._sel.)157.75
CD33+_Myeloid175.85
CD34+47
CD4+_Tcells123.8
CD56+_NKCells131.4
CD71+_EarlyErythroid6.95
CD8+_Tcells111.8
CardiacMyocytes19.55
Caudatenucleus22.9
Cerebellum27.4
CerebellumPeduncles23.25
CiliaryGanglion13.65
CingulateCortex20.05
Colorectaladenocarcinoma21.5
DorsalRootGanglion14.95
FetalThyroid14.6
Fetalbrain143.75
Fetalliver12.05
Fetallung9.6
GlobusPallidus14.5
Heart24.65
Hypothalamus35.75
Kidney6.45
Leukemia_chronicMyelogenousK-56216.4
Leukemia_promyelocytic-HL-6017.1
Leukemialymphoblastic(MOLT-4)14.05
Liver14.4
Lung24.35
Lymphnode52.6
Lymphoma_burkitts(Daudi)31.4
Lymphoma_burkitts(Raji)27.9
MedullaOblongata26.4
OccipitalLobe45.95
OlfactoryBulb24.9
Ovary7.55
Pancreas14.95
PancreaticIslet22.95
ParietalLobe26.65
Pituitary31.75
Placenta22.95
Pons17.6
PrefrontalCortex61
Prostate23.2
Salivarygland14.35
SkeletalMuscle17.8
Skin14.45
SmoothMuscle9.4
Spinalcord28.25
SubthalamicNucleus18.25
SuperiorCervicalGanglion13.3
TemporalLobe18.8
Testis25.25
TestisGermCell21.55
TestisIntersitial19.3
TestisLeydigCell17.7
TestisSeminiferousTubule17.2
Thalamus20.75
Thymus37.8
Thyroid22.1
Tongue6.8
Tonsil43.35
Trachea11.35
TrigeminalGanglion19.35
Uterus16.35
UterusCorpus16.7
WholeBlood28.55
Wholebrain65.85
colon14.55
pineal_day52.72
pineal_night93.26
retina36.425
small_intestine19.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P304171
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.89 ± 0.35
Basal Forebrain8.96 ± 0.07
Basal Part of Pons9.12 ± 0.23
Cerebellar Cortex8.99 ± 0.21
Cerebellar Nuclei8.79 ± 0.19
Claustrum8.98 ± 0.3
Epithalamus8.9 ± 0.13
Frontal Lobe9.06 ± 0.24
Globus Pallidus8.63 ± 0.16
Hypothalamus9.19 ± 0.27
Insula9.3 ± 0.24
Limbic Lobe9.06 ± 0.29
Mesencephalon8.96 ± 0.25
Myelencephalon9.01 ± 0.26
Occipital Lobe8.81 ± 0.26
Parietal Lobe9.04 ± 0.22
Pontine Tegmentum8.96 ± 0.24
Striatum8.9 ± 0.35
Subthalamus9.09 ± 0.1
Temporal Lobe9.12 ± 0.2
Thalamus8.87 ± 0.22
White Matter8.97 ± 0.1
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
1700021K19RikCBCerebellum26.22
27.87
1700021K19RikCTXCerebral cortex52.07
37.09
1700021K19RikHIPHippocampal region26.92
27.08
1700021K19RikHPFHippocampal formation35.56
31.69
1700021K19RikHYHypothalamus15.87
12.97
1700021K19RikLSXLateral septal complex16.41
13.4
1700021K19RikMBMidbrain18.9
16.78
1700021K19RikMYMedulla19.87
22.18
1700021K19RikOLFOlfactory bulb43.41
33.57
1700021K19RikPPons21.16
22.6
1700021K19RikPALPallidum19.23
15.98
1700021K19RikRHPRetrohippocampal region55.21
41.54
1700021K19RiksAMYStriatum-like amygdalar nuclei15.02
10.08
1700021K19RikSTRStriatum26.72
18.59
1700021K19RikSTRdStriatum dorsal region25.61
17.85
1700021K19RikSTRvStriatum ventral region41.28
27.27
1700021K19RikTHThalamus22.74
18.07
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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